LY 170055

LY 170055 - Names and Identifiers

Name	2-Methyl-4-(1-piperazinyl)-10H-thienol[2,3-b][1,5]benzodiazepine
Synonyms	LY 170055 Olanzapine-6 Desmethylolanzapine N-Demethyl olanzapine 4'-Desmethylolanzapine Olanzapine EP Impurity G 2-Methyl-4-(1-piperazinyl)-10H-thienol[2,3-b][1,5]benzodiazepine 2-Methyl-4-(1-Piperazinyl)-10H-Thieno-[2,3-b][1,5]Benzodiazepine 2-methyl-4-(piperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine
CAS	161696-76-0
InChI	InChI=1/C16H18N4S/c1-11-10-12-15(20-8-6-17-7-9-20)18-13-4-2-3-5-14(13)19-16(12)21-11/h2-5,10,17,19H,6-9H2,1H3

LY 170055 - Physico-chemical Properties

Molecular Formula	C16H18N4S
Molar Mass	298.41
Density	1.38±0.1 g/cm3(Predicted)
Melting Point	144.5°C
Boling Point	489.2±55.0 °C(Predicted)
Flash Point	13℃
Vapor Presure	1.02E-09mmHg at 25°C
pKa	8.58±0.10(Predicted)
Storage Condition	Sealed in dry,Store in freezer, under -20°C
Refractive Index	1.742

LY 170055 - Risk and Safety

Risk Codes	R11 - Highly Flammable R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36 - Irritating to the eyes
Safety Description	S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves.
UN IDs	UN 1648 3 / PGII
WGK Germany	2

LY 170055 - Introduction

2-methyl-4-(1-piperazinyl)-10H-thienol[2,3-b][1,5]benzodiazepine is an organic compound also known as TPZ(Thiophen film 10h-phenol).

Nature:
-Appearance: White to light yellow crystal
-Molecular formula: C16H11N3S
-Molecular weight: 277.34g/mol
-Melting point: 220-225 degrees Celsius
-Solubility: Soluble in organic solvents, slightly soluble in water

Use:
-Pharmaceutical field: as a kind of anti-tumor drugs. TPZ can be reduced to active metabolites in vivo, causing DNA damage and inducing cell apoptosis, so as to achieve the effect of tumor treatment.
-Other applications: TPZ is also used as an organic dye, photoelectric material and photosensitizer.

Method:
TPZ is usually synthesized as follows:
1.2-methyl -4-bromothiophene and 1-piperazine methylamine reaction, through the reduction and nucleophilic substitution reaction to form the target compound.

Safety Information:
The toxicity and safety of TPZ have not been fully studied. When used in the laboratory, general laboratory safety practices should be followed, such as wearing appropriate personal protective equipment (such as laboratory gloves, protective glasses) and ensuring that the operation is carried out under well-ventilated conditions. In addition, more detailed security assessments and protective measures should be carried out on a case-by-case basis.

Last Update：2024-04-09 20:52:54