Leflunomide EP Impurity H

Leflunomide EP Impurity H - Names and Identifiers

Name	Acetamide,2-cyano-N-[4-(trifluoromethyl)phenyl]-
Synonyms	Leflunomide Impurity H Leflunomide EP Impurity H 2-cyano-N-[4-(trifluoroMethyl)phenyl]- 2-Cyano-N-[4-(trifluoromethyl)phenyl]acetamide p-Acetotoluidide,2-cyano-a,a,a-trifluoro- (8CI) Acetamide,2-cyano-N-[4-(trifluoromethyl)phenyl]- Leflunomide Impurity 8(Leflunomide EP Impurity H)
CAS	24522-30-3

Leflunomide EP Impurity H - Physico-chemical Properties

Molecular Formula	C10H7F3N2O
Molar Mass	228.18
Density	1.375±0.06 g/cm3(Predicted)
Melting Point	145-147℃
Boling Point	386.3±42.0 °C(Predicted)
pKa	4.63±0.10(Predicted)
Storage Condition	Sealed in dry,Room Temperature

Leflunomide EP Impurity H - Upstream Downstream Industry

Raw Materials

1-CYANOACETYL-3,5-DIMETHYLPYRAZOLE
Acetyl chloride, cyano-
Ethyl cyanoacetate
Cyanoacetic acid
4-Aminobenzotrifluoride

Leflunomide EP Impurity H - Introduction

Acetamide,2-cyano-N-[4-(trifluoromethyl)phenyl]-is an organic compound with the chemical formula C10H8F3N3O.

Nature:
-Appearance: It is usually a white crystal or a powdery solid.
-Melting point: Its melting point is approximately between 95 and 98 ° C.
-Solubility: Its solubility in water is relatively low, but it can be well dissolved in organic solvents.

Use:
-Pesticide intermediate: It is a pesticide intermediate that can be used to synthesize pesticides and herbicides.
-Drug synthesis: It can also be used to synthesize drugs, such as antiepileptic drugs and antipsychotic drugs.

Method:
Acetamide,2-cyano-N-[4-(trifluoromethyl)phenyl]-can be prepared:
-First, tetrafluoromethylbenzene chloride (C6H4ClF3) is reacted with sodium cyanide (NaCN) to obtain cyanotetrafluoromethylbenzene (C6H4CNF3).
-Then, cyanotetrafluoromethylbenzene is reacted with Acetamide (C2H5NO) to obtain Acetamide,2-cyano-N-[4-(trifluoromethyl)phenyl]-.

Safety Information:
The compound may have certain toxicity, so appropriate safety measures should be taken when handling, such as wearing gloves and respiratory protection equipment. Avoid contact with oxidizing agents and strong acids during use or storage. Also, avoid inhalation, ingestion or contact with skin and eyes. All equipment and tools used shall be thoroughly cleaned after treatment. In the event of an accident, seek medical attention immediately and provide a safety data sheet for this compound.

Last Update：2024-04-09 21:11:58