LeptoMycin B( CI 940, LMB)
LEPTOMYCIN B FROM STREPTOMYCES SP
CAS: 87081-35-4
Molecular Formula: C33H48O6
LeptoMycin B( CI 940, LMB) - Names and Identifiers
LeptoMycin B( CI 940, LMB) - Physico-chemical Properties
| Molecular Formula | C33H48O6 |
| Molar Mass | 540.73 |
| Melting Point | 41-44°, with prior softening (Hokanson) |
| Specific Rotation(α) | D -24.5° (c = 0.70 in MeOH); D23 -157 ° (c = 0.7% in chloroform) |
| Flash Point | 11°(52°F) |
| Solubility | Supplied in solution in ethanol (1 mg/ml). Further dilutions may be made with either ethanol or DMSO. |
| Appearance | Liquid |
| Storage Condition | −20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions or dilutions in DMSO are not stable. Solutions should be made fresh and used within one working day. |
LeptoMycin B( CI 940, LMB) - Risk and Safety
| Risk Codes | R23/25 - Toxic by inhalation and if swallowed. R36/38 - Irritating to eyes and skin. R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S7 - Keep container tightly closed. S16 - Keep away from sources of ignition. S24 - Avoid contact with skin. S33 - Take precautionary measures against static discharges. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. |
| UN IDs | UN 1230 3/PG 2 |
| WGK Germany | 3 |
| HS Code | 29419090 |
| Hazard Class | 3 |
LeptoMycin B( CI 940, LMB) - References
| biological activity | Leptomycin B (CI 940; LMB) is a protein translocation inhibitor. Leptomycin inactivation of CRM1/exportin 1 by covalent modification at cysteine residues. Leptomycin B is a potent antifungal antibiotic that blocks the eukaryotic cell cycle. |
| target | CRM1/exportin 1 |
Last Update：2024-04-09 20:52:54
