Licochalcone C
Licochalcone C
CAS: 144506-14-9
Molecular Formula: C21H22O4
Licochalcone C - Names and Identifiers
Licochalcone C - Physico-chemical Properties
| Molecular Formula | C21H22O4 |
| Molar Mass | 338.4 |
| Density | 1.181±0.06 g/cm3 (20 ºC 760 Torr) |
| Boling Point | 536.1±50.0 °C(Predicted) |
| Solubility | Soluble in DMSO, methanol |
| Appearance | Yellow crystalline powder |
| pKa | 7.82±0.15(Predicted) |
| Storage Condition | 2-8℃ |
| Physical and Chemical Properties | Yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from licorice rhizome. |
| In vitro study | Licochalcone C could inhibit α- glucosidase, with IC50s of <100 nM and 92.43 μM for α- glucosidase and PTP1B, respectively. It is also indicated that Licochalcone C induces T24 cell apoptosis in a concentration‑dependent manner. Licochalcone C treatment reduces the levels of the anti‑apoptotic mRNAs (Bcl-2, Bcl-w and Bcl-XL) and increases expression of the pro-apoptotic mRNAs (Bax and Bim). The Bcl-2 family inhibitor (ABT-737) reduces apoptosis induced by licochalcone C in T24 cells. |
Licochalcone C - Reference
| Reference Show more | 1. [IF=2.629] Li Tingting et al."Quality Assessment of Licorice Based on Quantitative Analysis of Multicomponents by Single Marker Combined with HPLC Fingerprint."Evid-Based Compl Alt. 2021;2021:8834826 |
Licochalcone C - Reference Information
| Plant source: | Licorice |
| biological activity | Licochalcone C can inhibit α-glucosidase, and its IC50 values for α-glucosidase and protein tyrosine phosphatase 1B are |
| target | IC50: <100 nM (α-glucosidase), 92.43 μM (PTP1B). |
| use | licorice chalcone c has the effects of anti-ulcer, antibacterial, anti-inflammatory, hypolipidemic, free radical and antioxidant. used for content determination/identification/pharmacological experiment, etc. |
Last Update：2024-04-09 21:32:04
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Mobile: 18021002903
QQ: 3008007409
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