Low-Substituted Hydroxypropyl cellulose
Hydroxypropyl cellulose
CAS: 9004-64-2
Molecular Formula: C3H7O*
Low-Substituted Hydroxypropyl cellulose - Names and Identifiers
| Name | Hydroxypropyl cellulose |
| Synonyms | pm50 Klucel pm50(polymer) oxypropylatedcellulose syntheticvegetablegums HYDROXYPROPYL CELLULOSE Hydroxypropyl cellulose 2-Hydroxypropyl cellulose Cellulose, 2-hydroxypropyl ether HYDROXYPROPYLCELLULOSE, M.W.60,000 Low-Substituted Hydroxypropyl cellulose Hydroxypropyl cellulose, Average M.W. 100.000 1-[(5R)-3,4-bis(2-hydroxypropoxy)-6-(2-hydroxypropoxymethyl)-5-[(2S)-3,4,5-tris(2-hydroxypropoxy)-6-(2-hydroxypropoxymethyl)tetrahydropyran-2-yl]oxy-tetrahydropyran-2-yl]oxypropan-2-ol |
| CAS | 9004-64-2 |
| EINECS | 618-388-0 |
| InChI | InChI=1/C36H70O19/c1-19(37)9-45-17-27-29(47-11-21(3)39)31(48-12-22(4)40)34(51-15-25(7)43)36(54-27)55-30-28(18-46-10-20(2)38)53-35(52-16-26(8)44)33(50-14-24(6)42)32(30)49-13-23(5)41/h19-44H,9-18H2,1-8H3/t19?,20?,21?,22?,23?,24?,25?,26?,27?,28?,29?,30-,31?,32?,33?,34?,35?,36+/m1/s1 |
Low-Substituted Hydroxypropyl cellulose - Physico-chemical Properties
| Molecular Formula | C3H7O* |
| Molar Mass | 59.08708 |
| Density | 0.5 g/mL at 25 °C (lit.) |
| Melting Point | 371.06 °C |
| Boling Point | 891.2°C at 760 mmHg |
| Flash Point | 492.8°C |
| Water Solubility | Soluble in polar organic solvents, in water at room temperature.Soluble in water, methyl alcohol, ethyl alcohol and other organic solvents. |
| Solubility | polar oganic solvents: soluble |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | powder |
| Color | White to light cream |
| Merck | 14,4841 |
| PH | pH (20g/l, 25℃) : 5.0～7.5 |
| Storage Condition | Room Temperature |
| Stability | Stable. Incompatible with strong oxidizing agents. Combustible. |
| Refractive Index | 1.531 |
| MDL | MFCD00132688 |
| Physical and Chemical Properties | White or slightly yellow or gray granules or fibrous powder. Odorless, tasteless, flammable, thermoplastic. Swelling into a transparent to milky viscous colloidal solution in water. Soluble in ethanol, insoluble in ether. Insoluble in water above 38°C. |
| Use | Pharmaceutical industry as a binder and film forming agent, in cosmetics, coatings, ink industry as a film forming agent, dispersant, stabilizer, thickener, etc |
Low-Substituted Hydroxypropyl cellulose - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 1 |
| RTECS | NF9050000 |
| FLUKA BRAND F CODES | 3-10 |
| TSCA | Yes |
| HS Code | 39129000 |
Low-Substituted Hydroxypropyl cellulose - Reference
| Reference Show more | 1. Liu Wei, Liu Wen, Song Xinli, etc. Preparation and quality evaluation of breviscapine gastric adhesive tablets [J]. China Pharmacy, 2020(14). 2. Wang Guanhua, Liu Wen, Song Xinli, Liu Wei, Wang Yunxia, He Dongbo. Preparation and quality standard of total glucosides of paeony colon-specific tablets [J]. Chinese herbal medicines, 2019,42(11):2622-2626. 3. Cheng, S., zeng, W., liu, X. et al. Anti-evaluation Performance of Water in Soil. Water Air Soil Pollut 231,291 (2020). https://doi.org/10.1007/s11270-020-04679-8 4. [IF = 3.167] Lu Dai et al."Preparation and Characterization of Lactobacilli-Loaded Composite Films with Sustaining Antipathogenic Activity and Preservation Effect."J Food Sci. 2018 Oct;83(10):2511-2519 5. [IF=11.301] Xue Gao et al."Electric power generation using paper materials."J Mater Chem A. 2019 Sep;7(36):20574-20578 |
Low-Substituted Hydroxypropyl cellulose - Standard
Authoritative Data Verified Data
This product is low-substituted 2-hydroxypropyl ether cellulose. It is prepared by etherification reaction of cellulose after alkalization with propylene oxide at high temperature, followed by neutralization, recrystallization, washing, drying, pulverization and sieving. The hydroxypropoxyl group (-OCH2CHOHCH3) shall be 5.0% to 16.0% based on the dry product.
Last Update：2024-01-02 23:10:35
Low-Substituted Hydroxypropyl cellulose - Trait
Authoritative Data Verified Data
- This product is white or off-white powder; Odorless, tasteless.
- This product is insoluble in ethanol, acetone or ether.
Last Update：2022-01-01 11:22:40
Low-Substituted Hydroxypropyl cellulose - Introduction
Odorless, tasteless, flammable, thermoplastic. Swelling into a transparent to milky viscous colloidal solution in water. Soluble in ethanol, insoluble in ether, and insoluble in alcohol with high degree of substitution. Insoluble in water above 38°C.
Last Update：2022-10-16 17:29:51
Low-Substituted Hydroxypropyl cellulose - Differential diagnosis
Authoritative Data Verified Data
- take about 40mg of this product, put it in a test tube, add 2ml of water, shake to make a suspension, slowly add 1ml of 0.035% anthrone sulfuric acid solution along the tube wall, and show a blue-green ring at the interface of the two liquids.
- take 0. l g of this product, add 10ml of water, shake; Add l g of sodium hydroxide, shake and mix well, as a test solution. Take 0.1M l of sample solution, add 9ml of sulfuric acid solution (9-10), shake well, heat in water bath for 3 minutes, immediately cool in ice bath, add ninhydrin solution (take ninhydrin 0. 2G, add 10ml of water to dissolve, use new system) 0. 6ml, shake, place, that is, red, continue to stand for about 100 minutes, turn purple.
- take 5ml of the test solution under Item (2), add 10 ml of acetone-methanol (4: 1) mixed solution, shake, that is, a white flocculent precipitate is formed.
Last Update：2022-01-01 11:22:41
Low-Substituted Hydroxypropyl cellulose - Exam
Authoritative Data Verified Data
pH
take 0.10g of this product, add water 1 0 m l, shake, make a suspension, according to the law (General rule 0631),p H value should be 5.0~7. 5.
chloride
take this product 0. 10g, heat water 30ml, heat in the water bath for 10 minutes, while the heat filtration, the residue is washed with hot water 4 times, each 15ml, combined filtrate and wash in 100ml flask, cool, add water to dilute to the scale, shake; Take 10ml, check according to law (General rule 0801), and standard sodium chloride solution 2. Compared with the control solution made of 0M l, it should not be more concentrated (0.20%).
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 8.0% (General rule 0831).
ignition residue
The l.O g of this product shall be taken for inspection according to law (General rule 0841), and the residue shall not exceed 1 .0%.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 20 parts per million of heavy metal when examined by law (General rule 0821, Law II).
Iron Salt
take this product l .O g, after burning according to the method of burning the residue, add 5ml of dilute hydrochloric acid to the residue, heat and dissolve in a water bath, add water to 25ml, mix well; Take 5. 0ML, check according to law (General rule 0807), compared with the control solution made of standard iron solution 2_ 0ML, not deeper (0.010%).
arsenic salt
take this product l.O g, add calcium hydroxide l.O g, mix, add a small amount of water, stir evenly, after drying, slowly heat until charring, then burn at 500~600°C to completely Ash and cool, add hydrochloric acid 8M l and water 23ML, according to the law inspection (General Principles 0822 The first law), should comply with the provisions (0. 0002%).
Last Update：2022-01-01 11:22:41
Low-Substituted Hydroxypropyl cellulose - Content determination
Authoritative Data Verified Data
hydroxypropoxy
The measurement was carried out according to the methoxy, ethoxy and hydroxypropoxy method (General 0712). If the second method (capacity method) is used, take this product about O. lg, precision weighing, determination according to law, that is.
Last Update：2022-01-01 11:22:42
Low-Substituted Hydroxypropyl cellulose - Category
Authoritative Data Verified Data
pharmaceutical excipients, disintegrants and fillers.
Last Update：2022-01-01 11:22:42
Low-Substituted Hydroxypropyl cellulose - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 11:22:42
Low-Substituted Hydroxypropyl cellulose - Reference Information
| pH range of acid-base indicator discoloration | 5.0 - 8.5 |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Application | Low-substituted hydroxypropyl cellulose (L-HPC) is mainly used as tablet disintegrant and binder, and low-substituted hydroxypropyl cellulose (L-HPC) as a binder, disintegrating agent is characterized by: easy compression molding, strong applicability. As a tablet Binder, wet granulation is generally added 5 ~ 20%, powder direct compression dosage 5 ~ 20%, as a tablet disintegrating agent, dosage 2 ~ 10%, generally 5%, internal and External can be, depending on the specific prescription. Low-substituted hydroxypropyl cellulose (L-HPC) can also be used as a food additive, used in the food industry as an emulsifier, stabilizer, suspending agent, thickener, film forming agent, used in the manufacture of beverages, cakes, jam, etc, also used in the daily chemical industry, used in the manufacture of creams, shampoos, lotions and other cosmetics. |
| content analysis | hydroxypropoxyl content the instrument is shown in figure 10012B. The sample, which was pre-dried at 105 ° C. For 3H, was accurately weighed, about 85 mg, and transferred to boiling flask D, and 10ml of chromium trioxide solution (60g of water dissolved in ML) was added. Soak steam generator B and boiling bottle D in oil bath A at room temperature, based on the level of the immersion in the chromium trioxide solution. Cooling water was passed through the condenser F and nitrogen was passed through the boiling bottle at a rate of one bubble per second. The oil bath was allowed to warm up to 155 ° C. Over a period of 30min from room temperature and this temperature was maintained until the end of the assay. Distillation was carried out until 50ml of distillate was collected. The condenser was removed from the Vigreux fractionation column E, rinsed with water, and the wash was incorporated into the distillate vessel. The distillate was titrated with 0.02mol/L sodium hydroxide solution to pH 7.0 (with a pH meter). When titrating standard sample and blank test, phenolphthalein test solution (TS-167) can be used, and this shall prevail. The volume u of 0.02mol/L sodium hydroxide solution consumed was recorded. 241 mg of sodium bicarbonate and 10ml of dilute sulfuric acid solution (T) were added, and 1g of potassium iodide was added after the release of carbon dioxide was stopped. The flask was plugged and the mixture was shaken and placed in the dark for 5min. The free iodine was titrated with 0.02mol/L sodium thiosulfate until the yellow color suddenly disappeared, and the starch test solution (t§ 235) was added. Several drops to verify the endpoint. The volume (u) of 0.02mol/L sodium thiosulfate consumed was recorded. A blank titration was performed for each reagent with only chromium trioxide solution. The ratio of consumed sodium hydroxide solution (Vs) to sodium thiosulfate solution (yn) (after correcting the difference in concentration) is the ratio of acidity to oxidation, yt/yt-K, suitable for chromium trioxide carried in distillation. The coefficient K should be a constant for all determinations. A series of blank tests were performed as above with 0.02 mg methylcellulose (without extraneous impurities) instead of the sample, recording the consumption of mol/L |
| toxicity | ADI is not specified (FAO/WHO,2001). Safe for use in food (FDA,§ 172.870,2000). LD50 10200mg/kg (rat, oral). |
| Use | emulsifier, film coating agent, protective colloid, stabilizer, suspending agent, thickening agent. In Japan, 70% is used in medicine, as a tablet adhesive, film coating, etc. used as binder and film forming agent in pharmaceutical industry, used as film forming agent, dispersant, stabilizer and thickener in cosmetics, coatings and ink industry 1, used as adhesive agent: in the pharmaceutical field, this product is mainly used as a binder, such as tablets, granules, fine granules of the binder, generally 1-5% of the weight of the drug, choose RT-L or RT-J type. 2. Used as a film coating material for tablets. HPC has excellent film-forming properties, and the resulting film is tough and elastic, and can be compared with the plasticizer. By mixing with other temperature-resistant coating agents, the performance of the film can be further improved. The general choice of type RT-L. 3, used as a thickening agent of elixirs, lotion and emulsion stabilizer. The general choice of type RT-M. 4, can be used as the skeleton material preparation skeleton sustained-release tablets, sustained-release pellets and double-layer sustained-release tablets, generally choose RT-M type. 5, used as a gel when the ethanol field and used as an ointment base |
| production method | The cellulose was treated with alkali and propylene oxide. |
| autoignition temperature | 752 ° F. |
Last Update：2024-04-09 21:22:08
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