METHYL CHRYSIN
Tectochrysin
CAS: 520-28-5
Molecular Formula: C16H12O4
METHYL CHRYSIN - Names and Identifiers
METHYL CHRYSIN - Physico-chemical Properties
| Molecular Formula | C16H12O4 |
| Molar Mass | 268.26 |
| Density | 1.329±0.06 g/cm3(Predicted) |
| Melting Point | 166-168°C |
| Boling Point | 487.4±45.0 °C(Predicted) |
| Solubility | DMSO : 16.67 mg/mL (62.14 mM; Need ultrasonic) |
| Appearance | Yellow crystal |
| pKa | 6.34±0.40(Predicted) |
| Storage Condition | 2-8°C |
| MDL | MFCD00016945 |
| Physical and Chemical Properties | White needle-like crystals, soluble in methanol, ethanol, DMSO and other organic solvents, derived from the heartwood of Pinus cembra L. |
| In vitro study | Tectochrysin (Techtochrysin) inhibits activity of NF-κB. Tectochrysin (Techtochrysin) binds directly to the p50 unit. Tectochrysin (Techtochrysin) concentration-dependently inhibits the translocation of p50 and p65 into the nucleus through inhibition of the phosphorylation of IκB. To assess the inhibitory effect of Tectochrysin on cell growth of colon cancer cells (SW480, HCT116), cell viability is analyzed by MTT assay. The cells are treated with varying concentrations of Tectochrysin (Techtochrysin) (1, 5, 10 μg/mL) for 24 h. Tectochrysin (Techtochrysin) inhibits cell growth in colon cancer cells in a concentration-dependent manner. Tectochrysin (Techtochrysin) inhibits SW480 cells growth with IC 50 value of 6.3 μg/mL and HCT116 cells growth with IC 50 value of 8.4 μg/mL. Morphologic observation shows that the cells are reduced in size by the treatment of NSC 80687 (10 μg/mL) in SW480 cells and HCT116 cells. However, Tectochrysin (Techtochrysin) is not cytotoxic in the normal CCD-18co cells in the tested concentration by MTT assay. To delineate whether the induction of apoptotic cell death is critical for cell growth inhibition by NSC 80687, changes are evaluated in the chromatin morphology of cells using DAPI staining. To further characterize the apoptotic cell death by Tectochrysin (Techtochrysin), TUNEL staining assays are performed, and then the labeled cells are analyzed by fluorescence microscopy. Apoptotic cells number (DAPI-positive TUNEL stained cells) in SW480 cell is increased to 1 and 58 % by 0 and 10 μg/mL NSC 80687, respectively, and 1 and 54 % by 0 and 10 μg/mL Tectochrysin in HCT116. |
| In vivo study | To elucidate the antitumor effects of Tectochrysin in in vivo, the tumor growth in colon cancer xenograft-bearing nude mice following Tectochrysin (NSC 80687) treatments is investigated. In HCT116 xenograft studies, Tectochrysin (NSC 80687) is administrated i.p. twice per week for 3 weeks to mice with tumors ranging from 200 to 300 mm 3 in volume. The mice are weighed twice per week. The changes in body weights between the control and the Tectochrysin (NSC 80687)-treated mice (n=10) are not remarkably different during the experiment. However, On day 21, the final tumor weights are recorded. Tumor weights and volumes in mice treated with Tectochrysin (NSC 80687) at 5 mg/kg doses are 57.9 % and 46.4 % of the vehicle group, respectively. |
METHYL CHRYSIN - Risk and Safety
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| HS Code | 29145090 |
METHYL CHRYSIN - Reference
| Reference Show more | 1. [IF=11.413] Yanqiu Gu et al."Development of 3-mercaptopropyltrimethoxysilane (MPTS)-modified bone marrow mononuclear cell membrane chromatography for screening anti-osteoporosis components from Scutellariae Radix."Acta Pharm Sin B. 2020 Oct;10:1856 |
METHYL CHRYSIN - Reference Information
| biological activity | Tectochrysin (Tectochrysin, NSC 80687) is one of the major flavonoids of Alpinia oxyphylla Miquel. Tectochrysin significantly increased the expression of DR3, DR4 and Fas and inhibited the activity of NF-κB. Tectochrysin can induce apoptosis. |
| Target | Value |
| Use | euglumine can be used as a dye raw material. for content determination/identification/pharmacological experiments, etc |
Last Update：2024-04-09 21:11:58
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Product Name: 5-Hydroxy-7-methoxy-2-phenyl-4H-chromen-4-one Visit Supplier Webpage Request for quotationCAS: 520-28-5
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Tectochrysin Visit Supplier Webpage Request for quotationCAS: 520-28-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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