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MONTELUKAST SODIUM

Montelukast Sodium

CAS: 151767-02-1

Molecular Formula: C35H35ClNNaO3S

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MONTELUKAST SODIUM - Names and Identifiers

Name Montelukast Sodium
Synonyms mk-476
singulair
MONTELUKAST NA
MK-476, Singulair
Montelukast sodium
MONTELUKAST SODIUM
Montelukast Sodium
Montelukast, Sodium Salt
sodium(R,E)-2-(1-(1-(3-(-(7-chloroqulnolln-2-yl)-3-(2-(2 hydroxypropan-2-yl)phenyl)propylthio)cyclopropyl)acetate
1-[1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic
sodium (1-{[(1-{3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl}-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl)sulfanyl]methyl}cyclopropyl)acetate
2-[1-[[1-[3-[2-[(7-chloro-2-quinolyl)]vinyl]phenyl]-3-[2-(1-hydroxy-1-methyl-ethyl)phenyl]-propyl]sulfanylmethyl]cyclopropyl]acetic acid sodium salt
sodium {1-[({(1R)-1-{3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl}-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl}sulfanyl)methyl]cyclopropyl}acetate
Methyl-[E]-(+)-1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)-ethenyl]phenyl]-3-[2-(1-hydroxyl-1-methylethyl)phenyl]propyl]mercapto]methyl]cyclopropane acetic acid sodium
CAS 151767-02-1
EINECS 604-813-7
InChI InChI=1/C35H36ClNO3S.Na/c1-34(2,40)30-9-4-3-7-25(30)13-17-32(41-23-35(18-19-35)22-33(38)39)27-8-5-6-24(20-27)10-15-29-16-12-26-11-14-28(36)21-31(26)37-29;/h3-12,14-16,20-21,32,40H,13,17-19,22-23H2,1-2H3,(H,38,39);/q;+1/p-1/b15-10+
InChIKey LBFBRXGCXUHRJY-HKHDRNBDSA-M

MONTELUKAST SODIUM - Physico-chemical Properties

Molecular FormulaC35H35ClNNaO3S
Molar Mass608.17
Melting Point115 °C(dec.)
Boling Point750.5°C at 760mmHg
Specific Rotation(α)[α]/D +90 to +106° in methanol (c=1)
Solubility DMSO: ≥8mg/mL at 60°C
AppearanceWhite, brown powder
Colorwhite to tan
Merck14,6258
Storage Condition2-8°C
StabilityStable for 1 year from date of purchase as supplied. Solutions in DMSO, distilled water, or ethanol may be stored at -20°C for up to 1 month.
MDLMFCD00931431
In vitro studyMontelukast is a leukotriene receptor antagonist (LTRA) used for the continuous treatment of asthma and for the relief of seasonal allergic symptoms. Montelukast blocks the action of leukotriene D4 by binding to cysteinyl leukotriene receptor CysLT1 in the lungs and bronchi, preventing airway edema, smooth muscle contraction, and Secretory fluid viscosity. This reduces bronchoconstriction caused by Leukotrienes and makes inflammation less likely.
In vivo studyMontelukast (6 mg/kg once daily for 20 days) significantly inhibited the increased eosinophils in the BAL fluid and lung tissue of OVA-challenged mice and increased IL-5 levels in the BAL fluid. OVA challenge increases the cyslts receptor but decreases the mRNA expression of the CysLT2 receptor. Upon OVA challenge, Montelukast inhibited increased CysLT1 but did not reduce CysLT2 expression.

MONTELUKAST SODIUM - Risk and Safety

Hazard SymbolsXi - Irritant
Irritant
Risk CodesR63 - Possible risk of harm to the unborn child
R41 - Risk of serious damage to eyes
R62 - Possible risk of impaired fertility
Safety Description26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany3
RTECSGZ0698000
HS Code2933492250
MONTELUKAST SODIUM
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View History
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