MRT67307 HCl
MRT67307
CAS: 1190378-57-4
Molecular Formula: C26H36N6O2
MRT67307 HCl - Names and Identifiers
MRT67307 HCl - Physico-chemical Properties
| Molecular Formula | C26H36N6O2 |
| Molar Mass | 464.6 |
| Density | 1.270 |
| Solubility | H2O: soluble15mg/mL, clear |
| Appearance | powder |
| Color | white to light brown |
| pKa | 15.94±0.20(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| In vitro study | In macrophages, MRT67307 prevented IRF3 phosphorylation and IFNβ production. In wild-type MEF cells, MRT67307 enhanced the Ser933 phosphorylation of p105 stimulated by IL-1 and the phosphorylation of Ser468 and Ser536 of RelA, and IL-1 stimulated NF-Δb-dependent gene transcriptional activation was enhanced. In addition, the promotion of IL-10 production by MRT67307 and the inhibition of pro-inflammatory cytokines are achieved through a crtc3-dependent pattern. MRT67307 also inhibited ULK in MEF cells and blocked autophagy. |
MRT67307 HCl - Risk and Safety
| WGK Germany | 3 |
MRT67307 HCl - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.152 ml | 10.762 ml | 21.524 ml |
| 5 mM | 0.43 ml | 2.152 ml | 4.305 ml |
| 10 mM | 0.215 ml | 1.076 ml | 2.152 ml |
| 5 mM | 0.043 ml | 0.215 ml | 0.43 ml |
Last Update：2024-01-02 23:10:35
MRT67307 HCl - Reference Information
| biological activity | MRT67307 is a highly effective dual IKK/TBK1 inhibitor with IC50 of 160 and 19 nM respectively. MRT67307 can effectively inhibit ULK1 and ULK2 and restrict autophagy. |
| target | TargetValue IKK (Cell-Free Assay) 160 nM TBK1 (Cell-Free Assay) 190 nM |
| Target | Value |
| IKKϵ (Cell-free assay) | 160 nM |
| TBK1 (Cell-free assay) | 190 nM |
| In vitro study | In macrophages, MRT67307 prevented IRF3 phosphorylation and IFNβ production. In wild-type MEF cells, MRT67307 enhanced IL-1-stimulated Ser933 phosphorylation of p105 and Ser468 and Ser536 phosphorylation of RelA, and enhanced IL-1-stimulated NF-κB-dependent gene transcriptional activation. In addition, MRT67307 promotion of IL-10 production and inhibition of pro-inflammatory cytokines are achieved through CRTC3-dependent patterns. MRT67307 also inhibited ULK in MEF cells and blocked autophagy. |
Last Update：2024-04-09 15:16:36
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Spot supply
Product Name: MRT67307 Visit Supplier Webpage Request for quotationCAS: 1190378-57-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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