Marini
Kurarinone
CAS: 34981-26-5
Molecular Formula: C26H30O6
Marini - Names and Identifiers
Marini - Physico-chemical Properties
| Molecular Formula | C26H30O6 |
| Molar Mass | 438.51 |
| Density | 1?+-.0.06 g/cm3(Predicted) |
| Melting Point | 117-119℃ |
| Boling Point | 651.4±55.0 °C(Predicted) |
| Solubility | DMSO: 20 mg/mL |
| Appearance | white to beige( powder) |
| pKa | 7.49±0.40(Predicted) |
| Storage Condition | 2-8℃ |
Marini - Reference
| Reference Show more | 1. Huang, Y, Lin, H, Chen, Y, Huang, X. Pharmacokinetic and bioavailability study of kurarinone in dog plasma by UHPLC–MS/MS. Biomedical Chromatography. 2020; 34:e4945. https://doi.org/10.1002/bmc.4945 2. Wang, Zhihua, et al. "Comprehensive TCM molecular networking based on MS/MS in silico spectra with integration of virtual screening and affinity MS screening for discovering functional ligands from natural herbs." Analytical and bioanalytical chemistry 411 3. [IF=4.411] Jing Zhou et al."Simultaneous Optimization for Ultrasound-Assisted Extraction and Antioxidant Activity of Flavonoids from Sophora flavescens Using Response Surface Methodology."Molecules. 2019 Jan;24(1):112 |
Marini - Reference Information
| effect | as one of the flavonoids of "Sophora flavescens" in Qingluo drink, kushenone is better than matrine in the important process of endothelial cell proliferation, indicating that it has a significant effect. Kushenone has significant anti-endothelial cell proliferation activity. Sophora ketone has a significant inhibitory effect on endothelial cell proliferation, and the half inhibitory concentration (IC50) is 12ug/ml. Sophora ketone has significant inhibitory effect on HUVEC proliferation |
| separation and identification | 500g of dried Sophora flavescens was extracted 3 times at room temperature with 3000 ml of 95% ethanol, the extracts were combined, concentrated and evaporated to obtain 65g of crude extract. The extract was distributed three times by water and ethyl acetate, combined with ethyl acetate solution, concentrated and evaporated to obtain 30g extract. The extract was LH-20 by column chromatography with methanol as eluent to obtain 10g of crude product. The crude product was prepared by silica gel column chromatography, eluent acetone/petroleum ether = 1 ∶ 2, and reversed-phase material (RP-18) column chromatography, and 2 grams of Sophora ketone (yield 0.4%) was eluted with methanol/water = 65 ∶ 35. |
| biological activity | Kurarinone are flavonoids isolated from Sophora flavescens, which inhibit the pathogenesis of experimental autoimmune encephalomyelitis by inhibiting the cell differentiation of Th1 and Th17. |
Last Update：2024-04-09 19:05:04
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Spot supply
Product Name: Kurarinone Visit Supplier Webpage Request for quotationCAS: 34981-26-5
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Kurarinone Visit Supplier Webpage Request for quotationCAS: 34981-26-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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