Methyl 2-Bromo-4,5-Difluorobenzoate

Name	methyl 2-bromo-4,5-difluoro-benzoate
Synonyms	LogP Methyl 2-Bromo-4,5-Difluorobenzoate METHYL 2-BROMO-4,5-DIFLUOROBENZOATE methyl 2-bromo-4,5-difluoro-benzoate 2-Bromo-4,5-difluorobenzoic acid methyl ester Benzoic acid, 2-bromo-4,5-difluoro-, methyl ester benzoic acid, 2-bromo-4,5-difluoro-, methyl ester
CAS	878207-28-4
InChI	InChI=1/C8H5BrF2O2/c1-13-8(12)4-2-6(10)7(11)3-5(4)9/h2-3H,1H3

Molecular Formula	C8H5BrF2O2
Molar Mass	251.02
Density	1.652±0.06 g/cm3(Predicted)
Boling Point	249.5±40.0 °C(Predicted)
Flash Point	104.7°C
Vapor Presure	0.0229mmHg at 25°C
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Refractive Index	1.513

Use	methyl 2-bromo-4, 5-difluorobenzoate is useful as a pharmaceutical synthesis intermediate.
preparation	the preparation of methyl 2-bromo-4, 5-difluorobenzoate is as follows, to a mixture of 5-difluorobenzoic acid (1G, 4.22mmol) in dichloromethane (10ml) and MeOH(1ml) was added trimethylsilyl) diazomethane (2.110mL,4.22mmol) and the reaction stirred. At room temperature for 1 hour. It was then concentrated to give methyl 2-bromo-4, 5-difluorobenzoate (1G, 3.98mmol,94% yield) as an oil.

Last Update：2024-04-09 19:05:15