Methyl 5-bromo-1H-indazol...

Methyl 5-bromo-1H-indazol... - Names and Identifiers

Name	Methyl 5-bromo-1H-indazole-3-carboxylate
Synonyms	LogP Methyl 5-bromo-1H-indazol... Methyl-5-brom-1H-indazol-3-carboxylat 5-Bromo-3-(methoxycarbonyl)-1H-indazole METHYL 5-BROMO-1H-INDAZOLE-3-CARBOXYLATE Methyl 5-bromo-1H-indazole-3-carboxylate 1H-Indazole-3-carboxylicacid,5-broMo-,Methylester 5-Bromo-1H-indazole-3-carboxylic acid methyl ester 1H-indazole-3-carboxylic acid, 5-bromo-, methyl ester
CAS	78155-74-5
InChI	InChI=1/C9H7BrN2O2/c1-14-9(13)8-6-4-5(10)2-3-7(6)11-12-8/h2-4H,1H3,(H,11,12)

Methyl 5-bromo-1H-indazol... - Physico-chemical Properties

Molecular Formula	C9H7BrN2O2
Molar Mass	255.07
Density	1.709
Melting Point	208-210℃
Boling Point	399.7±22.0 °C(Predicted)
Flash Point	195.5°C
Vapor Presure	1.35E-06mmHg at 25°C
pKa	10.67±0.40(Predicted)
Storage Condition	2-8°C
Refractive Index	1.675

Methyl 5-bromo-1H-indazol... - Reference Information

Application

methyl 5-bromo-1h-indazole-3-carboxylate is an important pharmaceutical intermediate, for the construction of the active drug nucleus. 5-bromo-1h-indazole-3-carboxylic acid methyl ester has many reactive sites, and a series of derivative compounds can be synthesized by reacting with indazole nitrogen, carboxyl group, bromine atom and other sites.

preparation

1h-indazole-3-carboxylic acid is dissolved in a three-necked flask with anhydrous acetic acid, heated and stirred, after the substrate was dissolved and clarified, the liquid bromine was dissolved in anhydrous acetic acid and slowly added dropwise; The reaction was refluxed by condensation in an oil bath at 90 ° C. For 14 hours. After the reaction was completed, a white precipitate was produced, which was cooled in an ice bath, vacuum filtered, and the solid was washed with ethyl acetate and then with diethyl ether; Methyl 5-bromo-1h-indazole-3-carboxylate was obtained.

Last Update：2024-04-09 21:04:16