Methyl 5-bromo-4-chloronicotinate

Methyl 5-bromo-4-chloronicotinate - Names and Identifiers

Name	Methyl 5-bromo-4-chloronicotinate
Synonyms	Methyl 5-broMo-4-chloronicotinate Methyl 5-bromo-4-chloronicotinate methyl 5-bromo-4-chloronitronicotinat methyl 5-bromo-4-chloro-pyridine-3-carboxylate 5-Bromo-4-chloro-3-pyridinecarboxylic acid methyl ester 3-Pyridinecarboxylic acid, 5-bromo-4-chloro-, methyl ester
CAS	1256808-62-4
InChI	InChI=1S/C7H5BrClNO2/c1-12-7(11)4-2-10-3-5(8)6(4)9/h2-3H,1H3

Methyl 5-bromo-4-chloronicotinate - Physico-chemical Properties

Molecular Formula	C7H5BrClNO2
Molar Mass	250.48
Density	1.684±0.06 g/cm3(Predicted)
Melting Point	65 - 67°C
Boling Point	275.0±35.0 °C(Predicted)
Solubility	Chloroform (Slightly), Ethyl Acetate (Slightly)
Appearance	Solid
Color	White to Off-White
pKa	0.38±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C

Methyl 5-bromo-4-chloronicotinate - Introduction

Methyl 5-bromo-4-chloronicotinate is an organic compound with the chemical formula C6H4BrClO2CH3.

Nature:
5-Bromo-4-chloronicotinic acid methyl ester is a colorless liquid with a pungent odor. It is a combustible material, easy to burn in case of fire. It is denser and insoluble in water, but soluble in organic solvents such as ethanol and ether.

Use:
5-Bromo-4-chloronicotinic acid methyl ester is widely used in organic synthesis. It can be used as an intermediate of pesticides for the synthesis of other pesticide compounds. In addition, it is also used in the preparation of dyes and pharmaceutical intermediates.

Method:
A common preparation method is to react p-formic acid aniline and hydrochloric acid to generate p-chloroaniline, and then react with bromoformic acid to obtain 5-bromo -4-chloronicotinic acid methyl ester.

Safety Information:
5-bromo-4-chloronicotinic acid methyl ester is an organic solvent and irritating. Wear chemical protective gloves, goggles and protective clothing during use or operation. Avoid contact with skin, eyes and respiratory tract. In case of contact, flush with plenty of water and seek medical help. During storage and handling, keep away from fire and heat sources and keep good ventilation. It is strictly prohibited to mix with oxidant, strong acid, strong alkali and other substances.

Last Update：2024-04-09 15:17:51