Methyl 5-cyano-2-pyridinecarboxylate
2-Pyridinecarboxylicacid, 5-cyano-, methyl ester
CAS: 76196-66-2
Molecular Formula: C8H6N2O2
Methyl 5-cyano-2-pyridinecarboxylate - Names and Identifiers
Methyl 5-cyano-2-pyridinecarboxylate - Physico-chemical Properties
| Molecular Formula | C8H6N2O2 |
| Molar Mass | 162.15 |
| Density | 1.25±0.1 g/cm3(Predicted) |
| Boling Point | 323.6±27.0 °C(Predicted) |
| pKa | -1.75±0.10(Predicted) |
| Storage Condition | 2-8°C |
Methyl 5-cyano-2-pyridinecarboxylate - Introduction
2-Pyridinecarboxylicacid, 5-cyano-, methyl ester, chemical formula is C8H6N2O2. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: 2-Pyridinecarboxylicacid, 5-cyano-, methyl ester is a colorless to pale yellow liquid.
-Solubility: It can be dissolved in organic solvents such as ethanol, ether and dichloromethane, but it is almost insoluble in water.
-Melting point: The melting point of the compound is -18 to -16°C.
-Boiling point: Its boiling point is 254 to 258°C.
Use:
- 2-Pyridinecarboxylicacid, 5-cyano-, methyl ester can be used as an important intermediate in organic synthesis.
-It has potential applications in the field of medicinal chemistry, and can be used to prepare anti-cancer drugs, antiviral drugs, etc.
-In addition, it can also be used for the synthesis of dyes, optical materials and pesticides.
Preparation Method:
2-Pyridinecarboxylicacid, 5-cyano-, methyl ester can be prepared by the following steps:
1. take 5-cyanopyridine and sodium cyanide reaction, in ethanol to generate 5-cyanopyridine -2-acid sodium salt.
2. The sodium salt of 5-cyanopyridine-2-acid obtained is reacted with methyl formate in methanol to obtain 2-Pyridinecarboxylicacid, 5-cyano-, methyl ester.
Safety Information:
- 2-Pyridinecarboxylicacid, 5-cyano-, methyl ester is explosive under high temperature, fire source or oxidant.
-It may cause irritation and damage to the respiratory system, skin and eyes.
-Wear appropriate protective equipment such as gloves, safety goggles and face shields when used.
-Maintain good ventilation during operation and avoid direct contact with skin and eyes.
-In case of accidental ingestion or inhalation, seek medical attention immediately.
Nature:
-Appearance: 2-Pyridinecarboxylicacid, 5-cyano-, methyl ester is a colorless to pale yellow liquid.
-Solubility: It can be dissolved in organic solvents such as ethanol, ether and dichloromethane, but it is almost insoluble in water.
-Melting point: The melting point of the compound is -18 to -16°C.
-Boiling point: Its boiling point is 254 to 258°C.
Use:
- 2-Pyridinecarboxylicacid, 5-cyano-, methyl ester can be used as an important intermediate in organic synthesis.
-It has potential applications in the field of medicinal chemistry, and can be used to prepare anti-cancer drugs, antiviral drugs, etc.
-In addition, it can also be used for the synthesis of dyes, optical materials and pesticides.
Preparation Method:
2-Pyridinecarboxylicacid, 5-cyano-, methyl ester can be prepared by the following steps:
1. take 5-cyanopyridine and sodium cyanide reaction, in ethanol to generate 5-cyanopyridine -2-acid sodium salt.
2. The sodium salt of 5-cyanopyridine-2-acid obtained is reacted with methyl formate in methanol to obtain 2-Pyridinecarboxylicacid, 5-cyano-, methyl ester.
Safety Information:
- 2-Pyridinecarboxylicacid, 5-cyano-, methyl ester is explosive under high temperature, fire source or oxidant.
-It may cause irritation and damage to the respiratory system, skin and eyes.
-Wear appropriate protective equipment such as gloves, safety goggles and face shields when used.
-Maintain good ventilation during operation and avoid direct contact with skin and eyes.
-In case of accidental ingestion or inhalation, seek medical attention immediately.
Last Update：2024-04-09 20:52:54
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CAS: 76196-66-2
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QQ: 3008007409
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CAS: 76196-66-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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