Methylprednisolone Hydrogen Succinate EP Impurity A
6alpha-methylprednisolone
CAS: 83-43-2
Molecular Formula: C22H30O5
Methylprednisolone Hydrogen Succinate EP Impurity A - Names and Identifiers
Methylprednisolone Hydrogen Succinate EP Impurity A - Physico-chemical Properties
| Molecular Formula | C22H30O5 |
| Molar Mass | 374.47 |
| Density | 1.0868 (rough estimate) |
| Melting Point | 228-237°C (dec.) |
| Boling Point | 423.47°C (rough estimate) |
| Specific Rotation(α) | D20 +83° (dioxane) |
| Flash Point | 313.7°C |
| Water Solubility | 0.12g/L(25 ºC) |
| Solubility | chloroform/methanol (9:1): 50mg/mL, clear, faintly yellow |
| Vapor Presure | 1.86E-15mmHg at 25°C |
| Appearance | neat |
| Color | White to Off-White |
| Merck | 14,6111 |
| BRN | 2340300 |
| pKa | 12.46±0.70(Predicted) |
| Storage Condition | 0-6°C |
| Refractive Index | 82 ° (C=1, Dioxane) |
| Use | Suitable for rheumatoid arthritis, collagen disease, allergic diseases, ophthalmic diseases, lymphatic leukemia, soft tissue inflammation and hemolytic anemia |
| In vitro study | Methylprednisolone(2-10 mg/kg) significantly inhibited TNF production but did not affect IL-10 serum levels, whereas high dose Methylprednisolone(50 mg/kg) increased the level of LPS-induced IL-10. Methylprednisolone(0.01 to 100 mg/ml) also increased IL-10 biosynthesis by lipopolysaccharide-Activated Mouse peritoneal macrophages. |
| In vivo study | Methylprednisolone reduces RGC survival in rats with electrophysiologically diagnosed optic neuritis. Methylprednisolone reduces RGC survival by a non-genomic, calcium-dependent mechanism. Methylprednisolone-induced enhancement of RGC degeneration depends on calcium influx through voltage-gated calcium channels. In beak and tail stumps, Methylprednisolone treatment resulted in a significant reduction in the number of ed1-positive cells. Methylprednisolone resulted in a significant reduction in tissue loss for one week after treatment 2,4 and 8. After 1 and 2 weeks of transitional injury, Methylprednisolone caused a long-term decrease in ed1-positive cells and loss of spinal cord tissue, reduced vestibular fiber dieback, and instantaneous sprouting of vestibular fibers adjacent to the lesion. In a rat spinal cord injury model, Methylprednisolone(30 mg/kg) effectively improved functional outcomes, inhibited TNF-α expression and NF-kB activation. Methylprednisolone inhibits the function of NF-kB, probably induced by IKB, by trapping NF-kB in inactive cytoplasmic complexes. |
Methylprednisolone Hydrogen Succinate EP Impurity A - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 2 |
| RTECS | TU4146000 |
| FLUKA BRAND F CODES | 8-10-23 |
| HS Code | 2937290000 |
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CAS: 83-43-2
Tel: 17505222756
Email: pules.cn@gmail.com
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