Mirabegron Intermediate 4

Mirabegron Intermediate 4 - Names and Identifiers

Name	N-[2-(4-Aminophenyl)ethyl]-N-[(2R)-2-hydroxy-2-phenylethyl]carbamic acid tert-butyl ester
Synonyms	Mirabegron Intermediate 4 (R)-tert-Butyl 4-aminophenethyl(2-hydroxy-2-phenylethyl)carbamate tert-butyl (R)-N-[2-(4-aminophenyl)ethyl]-N-(2-hydroxy-2-phenylethyl)carbamate (N-tert-Butoxycarbonyl-N-[(1'R)-hydroxy-1-phenyl)ethyl])-4-aMinophenylethylaMine (N- tert-butoxy carbonyl -N-[((1'R) -hydroxy-1-phenyl) ethyl]) -4-aminophenyl ethyl amino N-[2-(4-Aminophenyl)ethyl]-N-[(2R)-2-hydroxy-2-phenylethyl]carbamic acid tert-butyl ester [2-(4-AMinophenyl)ethyl][(2R)-2-hydroxy-2-phenylethyl]carbaMic Acid 1,1-DiMethylethyl Ester CARBAMIC ACID, [2-(4-AMINOPHENYL)ETHYL][(2R)-2-HYDROXY-2-PHENYLETHYL]-, 1,1-DIMETHYLETHYL ESTER Carbamic acid, N-[2-(4-aminophenyl)ethyl]-N-[(2R)-2-hydroxy-2-phenylethyl]-, 1,1-dimethylethyl ester
CAS	223673-36-7
EINECS	1592732-453-0

Mirabegron Intermediate 4 - Physico-chemical Properties

Molecular Formula	C21H28N2O3
Molar Mass	356.46
Density	1.150
Solubility	Chloroform
Appearance	Brown Semi-Solid
Storage Condition	Keep in dark place,Inert atmosphere,Room temperature

Mirabegron Intermediate 4 - Introduction

N-[2-(4-Aminophenyl)ethyl]-N-[(2R)-2-hydroxy-2-phenylethyl]carbamic acid tert-butyl ester is an organic compound, often referred to as ABT (acronym for English name). The following is an introduction to the nature, use, formulation and safety information of ABT:

Nature:
-Appearance: White crystalline solid
-Molecular formula: C20H26N2O3
-Molecular weight: 342.43g/mol
-Melting point: About 80-85 ° C
-Solubility: Soluble in some organic solvents, such as methanol, ethanol, etc.

Use:
ABT has a wide range of applications.
-Chemical synthesis: ABT can be used as an intermediate in organic synthesis to synthesize various organic compounds, such as drugs and dyes.
-Pharmaceutical research: Due to its compatibility with organisms, ABT is also used in pharmaceutical research and development as a derivative of potential biologically active compounds.

Method:
The preparation method of ABT can be achieved through the following steps:
1. Obtaining the corresponding starting materials, such as methyl chloroformate and NaBH4, and appropriate solvents.
2. The methyl chloroformate is reacted with an appropriate amount of NaBH4 in a solvent to generate N-ethyl-N-methyl-acetamide (also known as formyl ethylamine).
3. Condensation of N-ethyl-N-methyl-acetamide with benzaldehyde to give the target compound N-[2-(4-aminophenyl)) ethyl]-tert-Butyl formate (alkaline hydrolysis can also be carried out by adding an appropriate amount of sodium bicarbonate in this process to generate the target compound).

Safety Information:
The safety information of ABT is limited, so care should be taken when using and handling it. Regular laboratory operating procedures should be followed and appropriate personal protective equipment should be worn. In any use or disposal of ABT, it is important to follow the guidelines for safe handling of chemicals. If you come into contact with this compound, rinse immediately with plenty of water and seek medical help.

Last Update：2024-04-09 20:49:11