Miransertib HCl
Miransertib (ARQ 092) HCl
CAS: 1313883-00-9
Molecular Formula: C27H25ClN6
Miransertib HCl - Names and Identifiers
Miransertib HCl - Physico-chemical Properties
| Molecular Formula | C27H25ClN6 |
| Molar Mass | 468.99 |
| Storage Condition | -20℃ |
| In vitro study | ARQ 092 prevents membrane translocation of inactivated AKT, dephosphorylates membrane-bound active AKT, thus destroying AKT activity. In neutrophils and platelets, treatment with 50-500 nM ARQ092 will significantly prevent αMβ2 integrin function (neutrophils), reduces exposure and glycoprotein Ib/IX/V-mediated platelet aggregation by P-selectin. ARQ092 inhibits the proliferation of multiple tumor cell types and is most effective in leukemia, breast, endometrial and colon cancer cells. Furthermore, inhibition of ARQ 092 was more prevalent in cancer cell lines containing PIK3CA/PIK3R1 mutations than in cancer cells containing wt-PIK3CA/PIK3R1 or PTEN mutations. ARQ 092 targets the PI3K/AKT signaling pathway and specifically targets AKT to reduce the phosphorylation of GSK3α and GSK3β in mutant-containing cells. |
| In vivo study | Short-term oral administration of ARQ 092 or hydroxyurea(hydroxyurea: The main therapeutic drug for anemia) can reduce the interaction between atypical cells and cells in the venules of anemic mice. ARQ 092 was well tolerated in humans with 60 mg daily or 600 mg weekly for several months. ARQ 092 may inhibit the activity of all AKT subtypes in intravascular cells, thereby attenuating thrombotic and inflammatory processes in SCD patients. ARQ 092 is highly active in a subset of endometrial tumors with mutations in the PI3K pathway gene. |
Miransertib HCl - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.132 ml | 10.661 ml | 21.322 ml |
| 5 mM | 0.426 ml | 2.132 ml | 4.264 ml |
| 10 mM | 0.213 ml | 1.066 ml | 2.132 ml |
| 5 mM | 0.043 ml | 0.213 ml | 0.426 ml |
Last Update：2024-01-02 23:10:35
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CAS: 1313883-00-9
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Product Name: Miransertib (ARQ 092) HCl Visit Supplier Webpage Request for quotation
CAS: 1313883-00-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 1313883-00-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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