N-(2,2,2-Trichloroethoxycarbonyloxy)succinim

N-(2,2,2-Trichloroethoxycarbonyloxy)succinim - Names and Identifiers

Name	Succinimidyl-2,2,2-trichloroethyl carbonate
Synonyms	Troc-OSU Succinimidyl-2,2,2-trichloroethyl carbonate SUCCINIMIDYL 2,2,2-TRICHLOROETHYL CARBONATE N-(2,2,2-Trichloroethoxycarbonyloxy)succinim N-(2,2,2-Trichloroethoxycarbonyloxy)succinimide N-(2,2,2-TRICHLOROETHOXYCARBONYLOXY)SUCCINIMIDE Troc-OSU Succinimidyl-2,2,2-trichloroethylcarbonate 2,5-Dioxopyrrolidin-1-yl (2,2,2-trichloroethyl) carbonate
CAS	66065-85-8
InChIKey	WBZXNGAFYBGQFE-UHFFFAOYSA-N

N-(2,2,2-Trichloroethoxycarbonyloxy)succinim - Physico-chemical Properties

Molecular Formula	C7H6Cl3NO5
Molar Mass	290.49
Melting Point	111-113°C(lit.)
Solubility	Soluble in dioxane, THF, DMF, CH2Cl2, alcohols, and most common organic solvents.
Storage Condition	Inert atmosphere,2-8°C
Sensitive	Moisture Sensitive

N-(2,2,2-Trichloroethoxycarbonyloxy)succinim - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37 - Irritating to eyes and respiratory system.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S27 - Take off immediately all contaminated clothing. S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S60 - This material and its container must be disposed of as hazardous waste. S36/37 - Wear suitable protective clothing and gloves. S9 - Keep container in a well-ventilated place.
UN IDs	UN 3335
WGK Germany	3
FLUKA BRAND F CODES	10-21
HS Code	29280000

N-(2,2,2-Trichloroethoxycarbonyloxy)succinim - Introduction

Succinimidyl 2,2, 2-trichloroethyl carbonate (Troc-Osu) is a reagent commonly used in organic synthesis. The following is an introduction to its nature, use, formulation and safety information:

Nature:
-Chemical formula: C7H6Cl3NO4
-Molecular weight: 296.49g/mol
-Appearance: White solid
-Melting point: 63-65°C
-Solubility: Soluble in organic solvents (such as chloroform, dimethylformamide), insoluble in water.

Use:
Troc-Osu commonly used in organic synthesis of hydroxyl protection and amino protection. It can introduce succinimide group during the synthesis process, so as to protect the active group (such as hydroxyl group), so as to prevent unwanted side reaction in the reaction. In organic synthesis reactions, Troc-Osu are often used to modify organic molecules to provide better conditions for subsequent chemical reactions.

Preparation Method:
Troc-Osu is generally prepared by reacting succinimide (Succinimide) with 2,2, 2-trichloroethanol (2,2,2-Trichloroethanol) in the presence of potassium carbonate. The reaction is typically carried out under an inert atmosphere to avoid moisture interference.

Safety Information:
Troc-Osu it is relatively safe under general operating conditions, the following should still be noted:
-During operation, direct contact with skin, eyes and mucous membranes should be avoided.
-It should be used in a well-ventilated area and wear suitable protective equipment (such as gloves, glasses, protective clothing, etc.).
-Avoid inhaling its dust or gas to avoid respiratory irritation or other health hazards.
-Waste should be disposed of according to local regulations to prevent environmental pollution.

In general, Troc-Osu is a reagent commonly used in organic synthesis for the protection of hydroxyl and amino groups. It can be obtained by reacting succinimide with 2,2, 2-trichloroethanol. Use should pay attention to safe operation, avoid direct contact and inhalation.

Last Update：2024-04-10 22:29:15