N-(2-Aminoethyl)-5-chloro-2-pyridinecarboxamide hydrochloride
N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid
CAS: 103878-83-7
Molecular Formula: C8H10ClN3O.HCl
N-(2-Aminoethyl)-5-chloro-2-pyridinecarboxamide hydrochloride - Names and Identifiers
N-(2-Aminoethyl)-5-chloro-2-pyridinecarboxamide hydrochloride - Physico-chemical Properties
| Molecular Formula | C8H10ClN3O.HCl |
| Molar Mass | 236.1 |
| Melting Point | 193-195° |
| pKa | 8.9(at 25℃) |
| Storage Condition | Desiccate at RT |
| In vitro study | The in vitro binding characteristics of both radiolabeled inhibitors revealed them to be selective, high-affinity ligands for the respective enzymes. K D and B max values for 3 H-Ro 19-6327 in rat cerebral cortex are 18.4 nM and 3.45 pmol/mg protein, respectively. The IC 50 values for lazabemide are: 86 μM for NA uptake; 123 μM for 5HT uptake; > 500 μM for DA uptake, respectively.. Lazabemide (5 μM) inhibits human MAO-B and MAO-A with IC 50 of 6.9 nM and >10 nM, respectively. And it inhibits rat MAO-B and MAO-A with IC 50 of 37 nM and >10 μM, respectively ina enzymatic assay.Lazabemide differs from L-deprenyl in their ability to induce release of endogenous monoamines from synaptosomes. Thus, Lazabemide (500 μM) induces a greater 5 HT release than does L-deprenyl, but is less effective than L-deprenyl in releasing DA. On the contrary, lazabemide was almost completely inactive on either 5 HT and DA release. Lazabemide (250 nM) results in a clear inhibition of DOPAC formation, while does not increase the accumulation of newly-formed DA in those tubular epithelial cells loaded with 50 microM L-DOPA. |
| In vivo study | Lazabemide (3 mg/kg) attenuates ichemia reperfusion-induced hydroxyl radical generation and pretreatment with Lazabemide showed decreased DOPAC levels in comparison with those of their respective vehicle-treated control groups. |
N-(2-Aminoethyl)-5-chloro-2-pyridinecarboxamide hydrochloride - Risk and Safety
| Toxicity | LD50 orally in mice: 1000-2000 mg/kg (Imhof, Kyburz, 1986) |
N-(2-Aminoethyl)-5-chloro-2-pyridinecarboxamide hydrochloride - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.235 ml | 21.177 ml | 42.355 ml |
| 5 mM | 0.847 ml | 4.235 ml | 8.471 ml |
| 10 mM | 0.424 ml | 2.118 ml | 4.235 ml |
| 5 mM | 0.085 ml | 0.424 ml | 0.847 ml |
Last Update：2024-01-02 23:10:35
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Product Name: N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid Visit Supplier Webpage Request for quotationCAS: 103878-83-7
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Mobile: 18021002903
QQ: 3008007409
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