N-(2-chloro-4-hydroxyphenyl)-N'-cyclopropyl-Urea
N-(2-chloro-4-hydroxyphenyl)-N'-cyclopropyl-Urea
CAS: 796848-79-8
Molecular Formula: C10H11ClN2O2
N-(2-chloro-4-hydroxyphenyl)-N'-cyclopropyl-Urea - Names and Identifiers
| Name | N-(2-chloro-4-hydroxyphenyl)-N'-cyclopropyl-Urea |
| Synonyms | lenvaint-I Lenvatinib Impurity a Lenvatinib Impurity LFS-A 1-(2-chloro-4-hydroxyphenyl)-3-cyclopropylurea (2-Chloro-4-hydroxyphenyl)-N'-cyclopropyl- urea N-(2-chloro-4-hydroxyphenyl)-N'-cyclopropyl-Urea Urea, N-(2-chloro-4-hydroxyphenyl)-N'-cyclopropyl- (Z)-N-(2-chloro-4-hydroxyphenyl)-N-cyclopropylcarbamimidic acid |
| CAS | 796848-79-8 |
N-(2-chloro-4-hydroxyphenyl)-N'-cyclopropyl-Urea - Physico-chemical Properties
| Molecular Formula | C10H11ClN2O2 |
| Molar Mass | 226.66 |
| Density | 1.43±0.1 g/cm3(Predicted) |
| Boling Point | 364.6±42.0 °C(Predicted) |
| pKa | 9.37±0.31(Predicted) |
| Storage Condition | 2-8°C |
N-(2-chloro-4-hydroxyphenyl)-N'-cyclopropyl-Urea - Introduction
N-(+)-N'-cyclopropyl-Urea is a compound whose chemical formula is C11H12ClN3O2. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: White crystalline powder
-melting point: 163-166 ℃
-Solubility: Slightly soluble in water, soluble in organic solvents such as ethanol, dimethylformamide, etc.
Use:
N-cyclopropyl-Urea are mainly used in agriculture as intermediates for pesticides and herbicides. It has a remarkable effect in controlling agricultural pests and weeds. In addition, it can also be used in the research field, for example as an intermediate in the chemical synthesis of medicines.
Preparation Method:
The method of preparing N-(Br)-N'-cyclopropyl-Urea can be achieved by the following steps:
1. 2-chloro-4-hydroxybenzamide is reacted with cyclopropyl isocyanate under alkaline conditions.
2. The reaction product was distilled and purified to obtain N-(¾)-N'-cyclopropyl-Urea.
Safety Information:
- N-(+)-N'-cyclopropyl-Urea should be stored in a dry, well-ventilated place away from direct sunlight.
-Use with appropriate protective equipment to avoid contact with skin and eyes.
-In case of contact or swallowing, rinse immediately with plenty of water and seek medical help.
-In the process of handling doses, relevant safety procedures and regulations for handling waste should be observed. The relevant Safety Data Sheet (MSDS) should be read and followed prior to use and storage.
Nature:
-Appearance: White crystalline powder
-melting point: 163-166 ℃
-Solubility: Slightly soluble in water, soluble in organic solvents such as ethanol, dimethylformamide, etc.
Use:
N-cyclopropyl-Urea are mainly used in agriculture as intermediates for pesticides and herbicides. It has a remarkable effect in controlling agricultural pests and weeds. In addition, it can also be used in the research field, for example as an intermediate in the chemical synthesis of medicines.
Preparation Method:
The method of preparing N-(Br)-N'-cyclopropyl-Urea can be achieved by the following steps:
1. 2-chloro-4-hydroxybenzamide is reacted with cyclopropyl isocyanate under alkaline conditions.
2. The reaction product was distilled and purified to obtain N-(¾)-N'-cyclopropyl-Urea.
Safety Information:
- N-(+)-N'-cyclopropyl-Urea should be stored in a dry, well-ventilated place away from direct sunlight.
-Use with appropriate protective equipment to avoid contact with skin and eyes.
-In case of contact or swallowing, rinse immediately with plenty of water and seek medical help.
-In the process of handling doses, relevant safety procedures and regulations for handling waste should be observed. The relevant Safety Data Sheet (MSDS) should be read and followed prior to use and storage.
Last Update：2024-04-09 15:18:00
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