N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-2-AMINO-BUTANOIC ACID
L-2-(fmoc-amino)butyric acid
CAS: 135112-27-5
Molecular Formula: C19H19NO4
N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-2-AMINO-BUTANOIC ACID - Names and Identifiers
| Name | L-2-(fmoc-amino)butyric acid |
| Synonyms | FMOC-ABU-OH Fmoc-Abu-OH FMOC-2-ABU-OH FMOC-ABU(2)-OH RARECHEM EM WB 0018 FMOC-2-AMINOBUTANOIC ACID Fmoc-L-2-aminobutyric acid Fmoc-L-2-Aminobutyric Acid (S)-Fmoc-2-aminobutyric acid L-2-(fmoc-amino)butyric acid N-ALPHA-FMOC-L-ALPHA-AMINOBUTYRIC ACID 2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}butanoic acid N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-2-AMINOBUTYRIC ACID N-alpha-(9-fluorenylmethyloxycarbonyl)-L-2-aminobutyric acid N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-2-AMINO-BUTANOIC ACID N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-ALPHA-AMINOBUTYRIC ACID |
| CAS | 135112-27-5 |
| EINECS | 828-203-7 |
| InChI | InChI=1/C19H19NO4/c20-17(19(22)23)9-10-18(21)24-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16-17H,9-11,20H2,(H,22,23) |
N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-2-AMINO-BUTANOIC ACID - Physico-chemical Properties
| Molecular Formula | C19H19NO4 |
| Molar Mass | 325.36 |
| Density | 1?+-.0.06 g/cm3(Predicted) |
| Melting Point | 161-163°C |
| Boling Point | 550.7±33.0 °C(Predicted) |
| BRN | 7657232 |
| pKa | 3.89±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.613 |
N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-2-AMINO-BUTANOIC ACID - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 2924 29 70 |
| Hazard Class | IRRITANT |
N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-2-AMINO-BUTANOIC ACID - Introduction
L-2-(fluorenylmethoxycarbonylamino) butyric acid, also known as Fmoc-glutamic acid (L-2-(9-fluorenylmethoxycarbonylamino) butyric acid), is an organic substance. The following is a description of some of its properties, uses, methods and safety information:
Nature:
-Appearance: Colorless or slightly yellow crystalline powder;
-Molecular formula: C26H23NO4;
-Molecular weight: 413.47g/mol;
-melting point: about 166-168 ℃;
-Solubility: Fmoc-glutamic acid is soluble in organic solvents such as dimethylformamide and hydrofluoric acid.
Use:
Fmoc-glutamic acid, as a protecting group compound, is often used in peptide synthesis, especially in the synthesis of stable peptide sequences and the synthesis of Levenstein peptides (Levenshtein peptide). It can be used as a synthetic intermediate of amino acids, or used in solid phase synthesis, high performance liquid chromatography, etc.
Preparation Method:
The preparation of Fmoc-glutamic acid generally includes the following steps:
1. In an anhydrous system, L-glutamic acid is reacted with Fmoc-OSu (fluorenylmethoxycarbonyl-chloro anhydride), and sodium chloride (NaCl) is used to promote the reaction to generate Fmoc-glutamic acid Fmoc-A salt.
2. For the Fmoc-glutamic acid salt, it is dissolved in a solvent (such as dimethylformamide) and subjected to an appropriate purification method (such as crystallization) to obtain Fmoc-glutamic acid.
Safety Information:
Fmoc-glutamic acid is generally relatively stable and low toxic under routine operation. But as an organic compound, still need to pay attention to the following safety measures:
-Avoid inhaling dust, contact with skin and eyes;
-During operation, wear protective gloves, glasses and protective clothing that meet safety requirements;
-Operate in a well-ventilated environment to avoid direct exposure for a long time;
-If waste from this compound is to be disposed of, it should be properly disposed of in accordance with local regulations.
Nature:
-Appearance: Colorless or slightly yellow crystalline powder;
-Molecular formula: C26H23NO4;
-Molecular weight: 413.47g/mol;
-melting point: about 166-168 ℃;
-Solubility: Fmoc-glutamic acid is soluble in organic solvents such as dimethylformamide and hydrofluoric acid.
Use:
Fmoc-glutamic acid, as a protecting group compound, is often used in peptide synthesis, especially in the synthesis of stable peptide sequences and the synthesis of Levenstein peptides (Levenshtein peptide). It can be used as a synthetic intermediate of amino acids, or used in solid phase synthesis, high performance liquid chromatography, etc.
Preparation Method:
The preparation of Fmoc-glutamic acid generally includes the following steps:
1. In an anhydrous system, L-glutamic acid is reacted with Fmoc-OSu (fluorenylmethoxycarbonyl-chloro anhydride), and sodium chloride (NaCl) is used to promote the reaction to generate Fmoc-glutamic acid Fmoc-A salt.
2. For the Fmoc-glutamic acid salt, it is dissolved in a solvent (such as dimethylformamide) and subjected to an appropriate purification method (such as crystallization) to obtain Fmoc-glutamic acid.
Safety Information:
Fmoc-glutamic acid is generally relatively stable and low toxic under routine operation. But as an organic compound, still need to pay attention to the following safety measures:
-Avoid inhaling dust, contact with skin and eyes;
-During operation, wear protective gloves, glasses and protective clothing that meet safety requirements;
-Operate in a well-ventilated environment to avoid direct exposure for a long time;
-If waste from this compound is to be disposed of, it should be properly disposed of in accordance with local regulations.
Last Update：2024-04-10 22:29:15
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