N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-AZETIDENE-2-CARBOXYLIC ACID
(S)-N-Fmoc-Azetidine-2-carboxylic acid
CAS: 136552-06-2
Molecular Formula: C19H17NO4
N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-AZETIDENE-2-CARBOXYLIC ACID - Names and Identifiers
| Name | (S)-N-Fmoc-Azetidine-2-carboxylic acid |
| Synonyms | RARECHEM EM WB 0078 (S)-N-FMOC-AZETIDINE-2-CARBOXYLIC ACID (S)-N-Fmoc-Azetidine-2-carboxylic acid 1-Fmoc-(S)-azetidine-2-carboxylic acid N-ALPHA-FMOC-L-AZETIDINE-2-CARBOXYLIC ACID (S)-N-(9-FLUORENYLMETHOXYCARBONYL)-AZETIDINE-2-CARBOXYLIC ACID (S)-N-(9-Fluorenylmethoxycarbonyl)-azetidine-2-carboxylic acid (2S)-1-[(9H-fluoren-9-ylmethoxy)carbonyl]azetidine-2-carboxylate N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-AZETIDINE-2-CARBOXYLIC ACID N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-AZETIDENE-2-CARBOXYLIC ACID (S)-AZETIDINE-1,2-DICARBOXYLIC ACID 1-(9H-FLUOREN-9-YLMETHYL) ESTER (2S)-1-[(9H-fluoren-9-ylmethoxy)carbonyl]azetidine-2-carboxylic acid |
| CAS | 136552-06-2 |
| InChI | InChI=1/C19H17NO4/c21-18(22)17-9-10-20(17)19(23)24-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16-17H,9-11H2,(H,21,22)/p-1/t17-/m0/s1 |
| InChIKey | BXRZCDISGRVJCA-KRWDZBQOSA-N |
N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-AZETIDENE-2-CARBOXYLIC ACID - Physico-chemical Properties
| Molecular Formula | C19H17NO4 |
| Molar Mass | 323.34 |
| Density | 1.2675 (rough estimate) |
| Melting Point | 135 °C |
| Boling Point | 461.82°C (rough estimate) |
| Flash Point | 282.3°C |
| Vapor Presure | 1.24E-12mmHg at 25°C |
| Appearance | Powder |
| Color | White to light yellow |
| pKa | 3.95±0.20(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.5000 (estimate) |
N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-AZETIDENE-2-CARBOXYLIC ACID - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29223990 |
| Hazard Class | IRRITANT |
N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-AZETIDENE-2-CARBOXYLIC ACID - Introduction
1-Fmoc-(S)-azetidine-2-carboxylic acid is an organic compound with the following properties:
Nature:
-Appearance: White solid
-Molecular formula: C25H21NO4
-Molecular weight: 395.44g/mol
-melting point: 165-170 ℃
Use:
1-Fmoc-(S)-azetidine-2-carboxylic acid is commonly used in protecting groups and intermediates in organic synthesis. It is mainly used as a method of amino protecting group in peptide synthesis, which can prevent non-specific reaction and side reaction. By controlling the protection and deprotection reactions of the amino group, a highly pure peptide sequence can be efficiently synthesized.
Preparation Method:
The preparation of 1-Fmoc-(S)-azetidine-2-carboxylic acid is generally accomplished by chemical reaction. A specific synthetic method may be the use of azetidine and phenyl difluoromethylmethyl ester to produce 1-Fmoc-(S)-azetidine-2-carboxylic acid.
Safety Information:
1-Fmoc-(S)-azetidine-2-carboxylic acid is a chemical, and safety measures should be taken when using it:
-Avoid inhalation or contact with skin and eyes. If contact occurs, rinse immediately with plenty of water.
-Appropriate personal protective equipment should be worn, including lab gloves, goggles, and lab coats.
-In operation, to maintain a good ventilation system or laboratory exhaust operation.
-should be stored away from fire and oxidant, in a dry, cool place, avoid direct sunlight.
-All handling and disposal shall comply with local codes and regulations.
Nature:
-Appearance: White solid
-Molecular formula: C25H21NO4
-Molecular weight: 395.44g/mol
-melting point: 165-170 ℃
Use:
1-Fmoc-(S)-azetidine-2-carboxylic acid is commonly used in protecting groups and intermediates in organic synthesis. It is mainly used as a method of amino protecting group in peptide synthesis, which can prevent non-specific reaction and side reaction. By controlling the protection and deprotection reactions of the amino group, a highly pure peptide sequence can be efficiently synthesized.
Preparation Method:
The preparation of 1-Fmoc-(S)-azetidine-2-carboxylic acid is generally accomplished by chemical reaction. A specific synthetic method may be the use of azetidine and phenyl difluoromethylmethyl ester to produce 1-Fmoc-(S)-azetidine-2-carboxylic acid.
Safety Information:
1-Fmoc-(S)-azetidine-2-carboxylic acid is a chemical, and safety measures should be taken when using it:
-Avoid inhalation or contact with skin and eyes. If contact occurs, rinse immediately with plenty of water.
-Appropriate personal protective equipment should be worn, including lab gloves, goggles, and lab coats.
-In operation, to maintain a good ventilation system or laboratory exhaust operation.
-should be stored away from fire and oxidant, in a dry, cool place, avoid direct sunlight.
-All handling and disposal shall comply with local codes and regulations.
Last Update：2024-04-10 22:29:15
