N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-ASPARTIC ACID ALPHA-METHYL ESTER
Fmoc-L-Aspartic acid 4-methyl ester
CAS: 145038-53-5;145038-52-4
Molecular Formula: C20H19NO6
N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-ASPARTIC ACID ALPHA-METHYL ESTER - Names and Identifiers
| Name | Fmoc-L-Aspartic acid 4-methyl ester |
| Synonyms | FMOC-ASP-OME FMOC-L-ASP-OME FMOC-ASP(OME)-OH Fmoc-L-Asp(OMe)-OH FMoc-Aspartic acid 4-Methyl ester Fmoc-L-Aspartic acid methyl ester Fmoc-L-Aspartic acid 4-methyl ester N-Fmoc-L-aspartic acid 1-methyl ester N-α-Fmoc-L-aspartic acid β-methyl ester (9H-Fluoren-9-yl)MethOxy]Carbonyl Asp-OMe N-(9-Fluorenylmethyloxycarbonyl)-L-Aspartic acid 4-methyl ester N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-ASPARTIC ACID ALPHA-METHYL ESTER (3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methoxy-4-oxobutanoic acid N-ALPHA-(9-FLUOROENYLMETHYLOXYCARBONYL)-L-ASPARTIC ACID ALPHA-METHYL ESTER (S)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)aMino)-4-Methoxy-4-oxobutanoic acid |
| CAS | 145038-53-5 145038-52-4 |
| InChI | InChI=1/C20H19NO6/c1-26-18(22)10-17(19(23)24)21-20(25)27-11-16-14-8-4-2-6-12(14)13-7-3-5-9-15(13)16/h2-9,16-17H,10-11H2,1H3,(H,21,25)(H,23,24)/t17-/m0/s1 |
N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-ASPARTIC ACID ALPHA-METHYL ESTER - Physico-chemical Properties
| Molecular Formula | C20H19NO6 |
| Molar Mass | 369.37 |
| Density | 1.322±0.06 g/cm3 (20 ºC 760 Torr) |
| Melting Point | 122-125 °C(Solv: hexane (110-54-3)) |
| Boling Point | 609.7±55.0 °C(Predicted) |
| Solubility | Chloroform, Methanol (Slightly) |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 4.05±0.19(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.596 |
N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-ASPARTIC ACID ALPHA-METHYL ESTER - Introduction
Fmoc-L-Aspartic acid 4-methyl ester is an organic compound commonly used in the fields of biochemistry and medicinal chemistry. The following is a description of its nature, use, preparation and safety information:
Nature:
Fmoc-L-Aspartic acid 4-methyl ester is a white to yellowish solid. It is stable at room temperature, but may decompose at high temperatures. It can be dissolved in most organic solvents, such as dimethyl sulfoxide, methylene chloride and ethanol.
Use:
Fmoc-L-Aspartic acid 4-methyl ester is a commonly used reagent for protecting amino acids. It may provide a protecting group for the amino acid by an esterification reaction with a methylene group upstream of the amino acid. Such a protecting group can block the reaction of the amino acid with other functional groups in chemical synthesis, thereby controlling the specific function of the amino acid.
Method:
The preparation of Fmoc-L-Aspartic acid 4-methyl ester usually involves the esterification of existing L-aspartic acid. One common method is an esterification reaction using methanol and an organic acid, such as propionic acid or acetic acid, in the presence of an acid catalyst. The reaction is then separated and purified to give the desired product.
Safety Information:
The safe use of Fmoc-L-Aspartic acid 4-methyl ester requires compliance with laboratory safety practices. It can be irritating to the eyes and skin, and may pose a health hazard when inhaled or ingested. Wear protective goggles, gloves and laboratory coats and keep them well ventilated during use. In case of any accident or discomfort, seek medical attention immediately.
Nature:
Fmoc-L-Aspartic acid 4-methyl ester is a white to yellowish solid. It is stable at room temperature, but may decompose at high temperatures. It can be dissolved in most organic solvents, such as dimethyl sulfoxide, methylene chloride and ethanol.
Use:
Fmoc-L-Aspartic acid 4-methyl ester is a commonly used reagent for protecting amino acids. It may provide a protecting group for the amino acid by an esterification reaction with a methylene group upstream of the amino acid. Such a protecting group can block the reaction of the amino acid with other functional groups in chemical synthesis, thereby controlling the specific function of the amino acid.
Method:
The preparation of Fmoc-L-Aspartic acid 4-methyl ester usually involves the esterification of existing L-aspartic acid. One common method is an esterification reaction using methanol and an organic acid, such as propionic acid or acetic acid, in the presence of an acid catalyst. The reaction is then separated and purified to give the desired product.
Safety Information:
The safe use of Fmoc-L-Aspartic acid 4-methyl ester requires compliance with laboratory safety practices. It can be irritating to the eyes and skin, and may pose a health hazard when inhaled or ingested. Wear protective goggles, gloves and laboratory coats and keep them well ventilated during use. In case of any accident or discomfort, seek medical attention immediately.
Last Update：2024-04-09 02:00:42
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Multiple SpecificationsSpot supply
Product Name: Fmoc-Asp(Ome)-OH Visit Supplier Webpage Request for quotationCAS: 145038-53-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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