N-Boc 3-iodoaniline

N-Boc 3-iodoaniline - Names and Identifiers

Name	(3-IODO-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER
Synonyms	N-Boc 3-iodoaniline TERT-BUTYL 3-IODOPHENYLCARBAMATE N-(tert-Butoxycarbonyl)-3-iodoaniline iodo-3-(tert-butyloxycarbonylamino)benzene 1-Iodo-3-[(tert-butyloxycarbonyl)aMino]benzene (3-IODO-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER N-(3-Iodophenyl)-1,1-diMethylethyl Ester CarbaMic Acid Carbamic acid, N-(3-iodophenyl)-, 1,1-dimethylethyl ester
CAS	143390-49-2

N-Boc 3-iodoaniline - Physico-chemical Properties

Molecular Formula	C11H14INO2
Molar Mass	319.14
Density	1.591±0.06 g/cm3(Predicted)
Melting Point	71-75°C
Boling Point	303.5±25.0 °C(Predicted)
Solubility	Dichloromethane, Ethyl Acetate
Appearance	Oil
Color	Yellow
pKa	13.30±0.70(Predicted)
Storage Condition	Room Temprature

N-Boc 3-iodoaniline - Risk and Safety

Risk Codes	R22 - Harmful if swallowed R43 - May cause sensitization by skin contact R50 - Very Toxic to aquatic organisms
Safety Description	S36/37 - Wear suitable protective clothing and gloves. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets.
UN IDs	UN 3077 9 / PGIII
WGK Germany	3

N-Boc 3-iodoaniline - Introduction

(3-iodo-phenyl)-CARBAMIC ACID TERT-BUTYL ESTER is an organic compound, its properties, uses, preparation methods and safety information are as follows:

Nature:
(3-IODO-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER is a white to light yellow solid that is flammable. It is stable at room temperature, but it is easy to decompose under high temperature, high pressure or light conditions. The compound is soluble in the solvent, but has a low solubility in water.

Use:
(3-IODO-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER is widely used in the field of organic synthesis. It is commonly used as a protecting group for aromatic amines. By protecting the nitrogen atom on the amine group, the activity and selectivity of the amine group can be protected during the chemical reaction. In addition, it is used in the preparation of intermediates and pharmaceuticals in organic synthesis.

Method:
(3-iodo-phenyl)-CARBAMIC ACID TERT-BUTYL ESTER is usually prepared by 3-iodoaniline as raw material through nuclear alkylation reaction and Boc ACID chloride reaction. The specific procedure involves the slow addition of the Boc acid chloride in a suitable solvent, followed by the addition of a base to neutralize the resulting HCl solution, and finally purification by crystallization to give the product.

Safety Information:
When using (3-IODO-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER, care should be taken to prevent contact with skin, eyes and administration. It is irritating and allergenic and may pose a health hazard. Personal protective equipment should be worn during operation, including laboratory coats, gloves and safety glasses. At the same time, good ventilation conditions should be ensured during operation, and fire sources and high temperature environments should be avoided. In case of inhalation, skin contact or eye contact, rinse immediately with water and seek medical help.

Last Update：2024-04-09 21:11:58