N-Methyl 4-fluorobenzamide
4-fluoro-N-methylbenzamide
CAS: 701-49-5
Molecular Formula: C8H8FNO
N-Methyl 4-fluorobenzamide - Names and Identifiers
| Name | 4-fluoro-N-methylbenzamide |
| Synonyms | 4-FLUORO-N-METHYLBENZAMIDE 4-fluoro-N-methylbenzamide 4-Fluoro-N-methylbenzamide N-Methyl 4-fluorobenzamide Benzamide, 4-fluoro-N-methyl- |
| CAS | 701-49-5 |
| InChI | InChI=1/C8H8FNO/c1-10-8(11)6-2-4-7(9)5-3-6/h2-5H,1H3,(H,10,11) |
N-Methyl 4-fluorobenzamide - Physico-chemical Properties
| Molecular Formula | C8H8FNO |
| Molar Mass | 153.15 |
| Density | 1.142±0.06 g/cm3(Predicted) |
| Melting Point | 133-134 °C |
| Boling Point | 276.2±23.0 °C(Predicted) |
| Flash Point | 120.9°C |
| Vapor Presure | 0.00486mmHg at 25°C |
| pKa | 14.88±0.46(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.506 |
| MDL | MFCD00032531 |
N-Methyl 4-fluorobenzamide - Introduction
4-fluoro-N-methylbenzamide is an organic compound with the chemical formula C8H8FNO. The following is an introduction to some of its properties, uses, formulation and safety information:
Nature:
-Appearance: Colorless crystal or white crystalline powder.
-Melting point: about 78-80 degrees Celsius.
-Boiling point: about 243 degrees Celsius.
-Solubility: Soluble in some organic solvents, such as ethanol and dimethyl sulfoxide.
-odor: with a special ammonia smell.
Use:
- 4-fluoro-N-methylbenzamide is commonly used in organic synthesis reactions and can be used as an important intermediate for the synthesis of a variety of compounds, such as drugs and pesticides.
-It can also be used for research and laboratory purposes, such as labeling compounds or as an internal standard for the determination of analytical samples.
Preparation Method:
At present, there are two main methods for the preparation of 4-fluoro-N-methylbenzamide:
-4-fluoro-N-hydrobenzamide is obtained by fluorination reaction of benzamide, and then N-methylation reaction is carried out under appropriate conditions to obtain the target product.
-4-fluoro-acetophenone is obtained by fluorination reaction of acetophenone, and then the target product is obtained by reduction and N-methylation reaction.
Safety Information:
- 4-fluoro-N-methylbenzamide should take appropriate protective measures during operation, such as wearing protective glasses and gloves, avoiding contact with skin and inhalation.
-It should be operated in a well-ventilated place and avoid contact with open flames or high temperatures.
-Avoid mixing with oxidants, strong acids and strong bases during storage to avoid dangerous reactions.
-For unintended contact or ingestion, seek medical attention immediately and bring the safety data sheet of the relevant compound to the hospital.
Nature:
-Appearance: Colorless crystal or white crystalline powder.
-Melting point: about 78-80 degrees Celsius.
-Boiling point: about 243 degrees Celsius.
-Solubility: Soluble in some organic solvents, such as ethanol and dimethyl sulfoxide.
-odor: with a special ammonia smell.
Use:
- 4-fluoro-N-methylbenzamide is commonly used in organic synthesis reactions and can be used as an important intermediate for the synthesis of a variety of compounds, such as drugs and pesticides.
-It can also be used for research and laboratory purposes, such as labeling compounds or as an internal standard for the determination of analytical samples.
Preparation Method:
At present, there are two main methods for the preparation of 4-fluoro-N-methylbenzamide:
-4-fluoro-N-hydrobenzamide is obtained by fluorination reaction of benzamide, and then N-methylation reaction is carried out under appropriate conditions to obtain the target product.
-4-fluoro-acetophenone is obtained by fluorination reaction of acetophenone, and then the target product is obtained by reduction and N-methylation reaction.
Safety Information:
- 4-fluoro-N-methylbenzamide should take appropriate protective measures during operation, such as wearing protective glasses and gloves, avoiding contact with skin and inhalation.
-It should be operated in a well-ventilated place and avoid contact with open flames or high temperatures.
-Avoid mixing with oxidants, strong acids and strong bases during storage to avoid dangerous reactions.
-For unintended contact or ingestion, seek medical attention immediately and bring the safety data sheet of the relevant compound to the hospital.
Last Update：2024-04-09 02:00:48
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CAS: 701-49-5
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CAS: 701-49-5
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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