N-Methyl N-Boc-ethanolamine
N-(tert.-Butoxycarbonyl)-N-methylethanolamine
CAS: 57561-39-4
Molecular Formula: C8H17NO3
N-Methyl N-Boc-ethanolamine - Names and Identifiers
N-Methyl N-Boc-ethanolamine - Physico-chemical Properties
| Molecular Formula | C8H17NO3 |
| Molar Mass | 175.23 |
| Density | 1.037±0.06 g/cm3(Predicted) |
| Boling Point | 120-126°C 4mm |
| Flash Point | 102.1°C |
| Water Solubility | Soluble in diochloromethane. Slightly soluble in water. |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Vapor Presure | 0.00487mmHg at 25°C |
| Appearance | Liquid |
| Color | Colorless to pale yellow |
| pKa | 14.67±0.10(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Refractive Index | 1.4410 to 1.4460 |
N-Methyl N-Boc-ethanolamine - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
N-Methyl N-Boc-ethanolamine - Introduction
N-(tert.-Butoxycarbonyl)-N-methylethanolamine(N-(tert.-Butoxycarbonyl)-N-methylethanolamine) is an organic compound with the following properties and uses:
Nature:
-Appearance: Colorless liquid or white crystalline solid
-Molecular formula: C9H19NO3
-Molecular weight: 193.25g/mol
-Melting point: about 46-48°C
-Boiling point: about 287°C
-Solubility: Soluble in most organic solvents such as ether, chloroform and methanol
Use:
N-(tert.-Butoxycarbonyl)-N-methylethanolamine are commonly used as protecting groups and intermediates in organic synthesis. The main uses include:
-Deprotection: The N-BOC group can be removed by acid catalysis, so as to protect other functional groups in the synthesis.
-Applied to peptide and drug synthesis: N-BOC protected α-amine compounds are important intermediates in peptide and drug synthesis.
Preparation Method:
N-(tert.-Butoxycarbonyl)-N-methylethanolamine can be synthesized by the following steps:
1. First, N-methylethanolamine and tert-butyl carbonate are reacted to produce N-BOC-N-methylethanolamine under alkaline conditions.
2. This reaction is usually carried out at a low temperature to avoid undesirable side reactions.
3. After completion of the reaction, the product was purified by crystallization or column chromatography.
Safety Information:
N-(tert.-Butoxycarbonyl)-N-methylethanolamine are less dangerous under correct use and storage conditions. However, the following should be noted:
-This compound may be irritating to the eyes, skin and respiratory tract. Please avoid direct contact.
-Wear suitable protective gloves, glasses and face shield when using or handling.
-Operate in a well-ventilated laboratory environment.
-Should be stored in a dry, cool, airtight container, away from direct sunlight.
-should not be in contact with strong oxidants and strong acids.
When using and handling chemicals, please strictly follow the relevant safety procedures to ensure personal safety and laboratory safety.
Nature:
-Appearance: Colorless liquid or white crystalline solid
-Molecular formula: C9H19NO3
-Molecular weight: 193.25g/mol
-Melting point: about 46-48°C
-Boiling point: about 287°C
-Solubility: Soluble in most organic solvents such as ether, chloroform and methanol
Use:
N-(tert.-Butoxycarbonyl)-N-methylethanolamine are commonly used as protecting groups and intermediates in organic synthesis. The main uses include:
-Deprotection: The N-BOC group can be removed by acid catalysis, so as to protect other functional groups in the synthesis.
-Applied to peptide and drug synthesis: N-BOC protected α-amine compounds are important intermediates in peptide and drug synthesis.
Preparation Method:
N-(tert.-Butoxycarbonyl)-N-methylethanolamine can be synthesized by the following steps:
1. First, N-methylethanolamine and tert-butyl carbonate are reacted to produce N-BOC-N-methylethanolamine under alkaline conditions.
2. This reaction is usually carried out at a low temperature to avoid undesirable side reactions.
3. After completion of the reaction, the product was purified by crystallization or column chromatography.
Safety Information:
N-(tert.-Butoxycarbonyl)-N-methylethanolamine are less dangerous under correct use and storage conditions. However, the following should be noted:
-This compound may be irritating to the eyes, skin and respiratory tract. Please avoid direct contact.
-Wear suitable protective gloves, glasses and face shield when using or handling.
-Operate in a well-ventilated laboratory environment.
-Should be stored in a dry, cool, airtight container, away from direct sunlight.
-should not be in contact with strong oxidants and strong acids.
When using and handling chemicals, please strictly follow the relevant safety procedures to ensure personal safety and laboratory safety.
Last Update：2024-04-10 22:29:15
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CAS: 57561-39-4
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: (2-HYDROXYETHYL)METHYLCARBAMIC ACID 1,1-DIMETHYLETHYL ESTER Visit Supplier Webpage Request for quotationCAS: 57561-39-4
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