N-Methyl-4-phenylpyridinium iodide

N-Methyl-4-phenylpyridinium iodide - Names and Identifiers

Name	MPP+ IODIDE
Synonyms	MPP+ IODIDE 4-phenylpyridin-1-ium iodide 1-methyl-4-phenyl-pyridiniuiodide N-Methyl-4-phenylpyridinium iodide 1-Methyl-4-phenylpyridin-1-iuM iodide Pyridinium, 1-methyl-4-phenyl-, iodide MPP+ iodide,1-Methyl-4-phenylpyridinium iodide MPP+ IODIDE (ACTIVE METABOLITE OF DOPAMI NERGIC NEUROTOX
CAS	36913-39-0
InChIKey	RFDFRDXIIKROAI-UHFFFAOYSA-M

N-Methyl-4-phenylpyridinium iodide - Physico-chemical Properties

Molecular Formula	C12H12IN
Molar Mass	297.13
Melting Point	166-168 °C
Water Solubility	0.1 M HCl: soluble
Appearance	Form solid color yellow
Storage Condition	desiccated
Use	MPP iodide is a toxic metabolite of the neurotoxin MPTP, which causes Parkinson's disease symptoms in animal models by selectively destroying dopaminergic neurons in the substantia nigra. MPP ioside is absorbed into dopaminergic neurons by dopamine transporters and exerts neurotoxic effects on mitochondria by affecting respiratory chain complex I. MPP iodide is also a high affinity substrate for serotonin transporters (SERT).

N-Methyl-4-phenylpyridinium iodide - Risk and Safety

Hazard Symbols	T - Toxic
Risk Codes	R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R25 - Toxic if swallowed
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN 2811 6.1/PG 2
WGK Germany	3
RTECS	UU6580000

N-Methyl-4-phenylpyridinium iodide - Research

MPP (1-3 mM; 24 hours) remarkably decreases the viability of cells.
MPP also inhibits the activity of nicotinamide adenosine dinucleotide (NADH)-linked respiration in mitochondrial preparations and impairs aerobic glycolysis, leading to the present belief that the inhibition of NADH-linked cell respiration may constitute the final molecular mechanism of MPP neurotoxicity.

Cell Viability Assay

Cell Line:	SH-SY5Y cells
Concentration:	1, 2, 3 mM
Incubation Time:	24 hours
Result:	SH-SY5Y cells were treated with MPP , mimicking the progress of dopaminergic neurons loss in PD; Reduced cell viability in both dose-dependent (1, 2, 3 mM for 24 h) and time dependent (1 mM) manner.