N2-METHYLGUANINE

Name	6-HYDROXY-2-METHYLAMINOPURINE
Synonyms	N2-METHYLGUANINE 2-(MethylaMino)-7H-purin-6-ol 6-HYDROXY-2-METHYLAMINOPURINE 2-(MethylaMino)-1H-purin-6(7H)-one 2-methylamino-3,7-dihydropurin-6-one 1,7-Dihydro-2-(methylamino)-6H-purin-6-one 2-(methylamino)-6,7-dihydro-3H-purin-6-one 6H-Purin-6-one,1,9-dihydro-2-(methylamino)-
CAS	10030-78-1

Molecular Formula	C6H7N5O
Molar Mass	165.15
Storage Condition	4°C, Inert atmosphere
In vitro study	2-(Methylamino)-1H-purin-6(7H)-one (N2-methylguanine) is found within both helical and looped regions of RNA secondary structure, and it can exist in either the s-cis or the s-trans rotamer. If there is a rotational preference for the methyl group, the effect of 2-(Methylamino)-1H-purin-6(7H)-one substitution may be specific to the sequence context depending upon which face of the base participates in hydrogen bonding. 2-(Methylamino)-1H-purin-6(7H)-one (N2-methylguanine) is the principal kinetic barrier for reverse transcription in the 1340 bases proximal to the 5' end of E. coli 16S rRNA. Transcription intermediates correspond to attenuation at the positions of 2-(Methylamino)-1H-purin-6(7H)-one in the rRNA sequence. The relaxation time for elongation of the cDNA through m2G is approximately 3 min.

Last Update：2024-01-02 23:10:35

biological activity

2-(methyllamino)-1H-purin-6(7H)-one (N2-Methylguanine) is a modified nucleoside, are endogenous methylated nucleosides present in human body fluids.

Last Update：2024-04-09 20:52:54

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CAS: 10030-78-1
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N2-METHYLGUANINE

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