NANDROLONE PHENPROPIONATE

NANDROLONE PHENPROPIONATE - Names and Identifiers

Name	nandrolone 3-phenylpropionate
Synonyms	durabol durabolin NANDROLONE PHENPROPIONATE Nandrolone Phenpropionate NANDROLONI PHENYLPROPIONAS Nandrolone phenylpropionate NANDROLONE PHENYLPROPIONATE nandrolone 3-phenylpropionate 19-NORTESTOSTERONE PHENYLPROPIONATE 3-oxoestr-4-en-17-yl 3-phenylpropanoate 4-ESTREN-17B-OL-3-ONE 17-PHENYLPROPIONATE 4-ESTREN-17-BETA-OL-3-ONE PHENYLPROPIONATE 4-ESTREN-17BETA-OL-3-ONE 17-PHENYLPROPIONATE 17b-hydroxyestr-4-en-3-one 17-(3-phenylpropionate)
CAS	62-90-8
EINECS	200-551-9
InChI	InChI=1/C27H34O3/c1-27-16-15-22-21-11-9-20(28)17-19(21)8-10-23(22)24(27)12-13-25(27)30-26(29)14-7-18-5-3-2-4-6-18/h2-6,17,21-25H,7-16H2,1H3
InChIKey	UBWXUGDQUBIEIZ-QNTYDACNSA-N

NANDROLONE PHENPROPIONATE - Physico-chemical Properties

Molecular Formula	C27H34O3
Molar Mass	406.57
Density	1.0140 (rough estimate)
Melting Point	85-87°C
Boling Point	487.61°C (rough estimate)
Specific Rotation(α)	D +58° (chloroform)
Flash Point	234.6°C
Vapor Presure	5.12E-12mmHg at 25°C
Storage Condition	Controlled Substance, -20°C Freezer
Refractive Index	1.5460 (estimate)
Physical and Chemical Properties	White or milky white crystalline powder, with special odor. Practically insoluble in water, soluble in ethanol or fatty oil, melting point 93-99 ℃. Protein anabolic hormone, can promote protein metabolism and calcium accumulation, its role is strong and lasting.
Use	For chronic wasting disease, severe burns, inoperable breast cancer, functional uterine bleeding.

NANDROLONE PHENPROPIONATE - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R40 - Limited evidence of a carcinogenic effect
Safety Description	S23 - Do not breathe vapour. S36 - Wear suitable protective clothing.
RTECS	KG7995000
Toxicity	LD50 intraperitoneal in mouse: > 1gm/kg

NANDROLONE PHENPROPIONATE - Standard

Authoritative Data Verified Data

This product is 17b-hydroxy-estradiol g-4-en-3-keto-3-phenylpropionate. The content of C27H3403 shall be between 97.0% and 103.0% based on the dry product.

Last Update：2024-01-02 23:10:35

NANDROLONE PHENPROPIONATE - Trait

Authoritative Data Verified Data

This product is white or white crystalline powder; Special odor.
This product is dissolved in methanol or ethanol, slightly soluble in vegetable oil, almost insoluble in water.

melting point

The melting point of this product (General 0612) is 93~99°C.

specific rotation

take this product, precision weighing, plus dioxane dissolution and quantitative dilution of about 10 mg per lml solution, according to the law (General 0621), specific rotation: 48 ° to 51 °.

Last Update：2022-01-01 13:33:38

NANDROLONE PHENPROPIONATE - Differential diagnosis

Authoritative Data Verified Data

in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 231).

Last Update：2022-01-01 13:33:38

NANDROLONE PHENPROPIONATE - Exam

Authoritative Data Verified Data

Related substances

take this product, add methanol to dissolve and dilute to make a solution containing about 2mg per 1 ml as a test solution; Take 2ml for precision measurement and put it in a 100ml measuring flask, as a control solution, it was diluted to the scale with methanol and shaken. In addition to the detection wavelength of 254nm, according to the chromatographic conditions under the content determination item, take the sample solution and the control solution 10 u1, respectively, and inject the human liquid chromatograph, the chromatogram was recorded to 2 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 0.5 times (1.0%) of the area of the main peak of the control solution, the sum of each impurity peak area shall not be greater than 0.75 times (1.5%) of the main peak area of the control solution. The chromatogram of the test solution is 0.01 times smaller than the main peak area of the control solution.

loss on drying

take this product, put it in a phosphorus pentoxide dryer, and dry it under reduced pressure to constant weight. The weight loss shall not exceed 0.5% (General rule 0831).

Last Update：2022-01-01 13:33:39

NANDROLONE PHENPROPIONATE - Content determination

Authoritative Data Verified Data

measured by high performance liquid chromatography (General 0512).

chromatographic conditions and system suitability test

silica gel bonded with eighteen alkyl silane was used as the filler, and methanol-water (82:18) was used as the mobile phase. The detection wavelength was at 241NM. Take nandrolone phenylpropionate and testosterone propionate, dissolve and dilute with methanol to make a solution containing about 0.4mg in each lml, and inject 10ul into the liquid chromatograph. The peak order is testosterone propionate and nandrolone phenylpropionate in turn, the degree of separation between the testosterone propionate peak and the nandrolone phenylalanine peak should be greater than 10.0.

assay

take about 20mg of this product, weigh it accurately, put it in 50ml measuring flask, add methanol to dissolve and dilute it to the scale, shake it well, and use it as a test solution, 10u1 was injected into the liquid chromatograph to record the chromatogram. Another reference substance of nandrolone phenylpropionate was taken and determined by the same method. According to the external standard method to calculate the peak area, that is.

Last Update：2022-01-01 13:33:40

NANDROLONE PHENPROPIONATE - Category

Authoritative Data Verified Data

anabolic hormone drugs.

Last Update：2022-01-01 13:33:40

NANDROLONE PHENPROPIONATE - Storage

Authoritative Data Verified Data

light shielding, sealed storage.

Last Update：2022-01-01 13:33:40

NANDROLONE PHENPROPIONATE - Nandrolone Phenylpropionate Injection

Authoritative Data Verified Data

This product is a sterile oil solution of nandrolone phenylpropionate. Nandrolone phenylalanine (C27H3403) shall be between 90.0% and 110.0% of the labeled amount.

trait

This product is a light yellow clear oily liquid.

identification

take an appropriate amount of this product (about 50mg equivalent to nandrolone phenylpropionate), add 8ml of petroleum ether (boiling range 40-60°C) to dissolve nandrolone phenylpropionate, and use glacial acetic acid-water (7:3). Extract 3 times, each time 8ml, combined extract, with petroleum ether (boiling range 40~60°C )10ml wash once, discard the wash solution, extract diluted with water until the solution became turbid with precipitate, the mixture was placed in an ice bath for 2 hours and filtered; The precipitate was washed with water and dried in a phosphorus pentoxide dryer under reduced pressure to obtain a white crystalline powder. An appropriate amount of this powder and the reference substance of nandrolone phenylpropionate were dissolved in acetone to prepare a solution containing 5mg per 1 ml, respectively, as a test solution and a reference solution. According to the thin layer chromatography (General 0502) test, absorb 10 u1 of each of the above two solutions, respectively point on the same silica gel G thin layer plate, with n-heptane-acetone (2:1) as the developing solvent, it was developed, dried, sprayed with sulfuric acid-ethanol (1:49) and heated at 110°C for 15 minutes. The position and color of the main spot displayed by the test solution should be the same as that of the reference solution.
in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
two items (1) and (2) above can be selected as one item.

examination

the relevant substances should be accurately measured with the internal volume pipette. Take an appropriate amount of this product (about equivalent to lOOmg of nonorong phenylpropionate), put it in a 10ml measuring flask, wash the inner wall of the pipette with ether for several times, wash the liquid and put it in the measuring flask, dilute with diethyl ether to the scale, shake; Take 5ml with precision, put the plug in the centrifuge tube, and volatilize the diethyl ether in a warm water bath, 4 times with methanol shaking extraction (1~3 times each 5ml, 4 times 3ml), 10 minutes each time after centrifugation 15 minutes, and the methanol solution is transferred to 25ml flask with dropper, the extracts were combined, diluted to scale with methanol, and shaken to serve as a test solution. Determination was carried out according to the method for related substances of nandrolone phenylpropionate. If there are impurity peaks in the chromatogram of the test solution, the benzyl alcohol peak shall be subtracted, and the area of a single impurity peak shall not be greater than 0.5 times (1.0%) of the area of the main peak of the control solution, the sum of each impurity peak area shall not be greater than 0.75 times (1.5%) of the main peak area of the control solution. The chromatogram of the test solution is 0.01 times smaller than the main peak area of the control solution.
others should comply with the relevant provisions under injection (General 0102).

Content determination

take an appropriate amount of this product (about 50mg equivalent to nandrolone phenylpropionate) with the internal volume pipette, put it in a 25ml measuring flask, wash the inner wall of the pipette with ether for several times, wash the liquid and put it in the measuring flask, dilute with diethyl ether to the scale, shake; Take 5ml with precision, put the plug in the centrifuge tube, and volatilize the diethyl ether in a warm water bath, 4 times with methanol shaking extraction (1~3 times each 5ml, 4 times 3ml), 10 minutes each time after centrifugation 15 minutes, and the methanol solution is transferred to 25ml flask with dropper, the extracts were combined, diluted to a scale with methanol, and shaken to obtain a test solution, which was determined according to the method under the item of determination of the content of nandrolone phenylpropionate.

specification

(l ) lml:1Omg ( 2 ) lml:25mg

storage

light shielding, closed storage.

Last Update：2022-01-01 13:33:41

NANDROLONE PHENPROPIONATE - Reference Information

.
2. Anabolic hormone can reduce glucose tolerance, patients with diabetes should pay attention to adjust insulin or oral hypoglycemic drug dose.
3. The other was the same as methyltestosterone.

NIST chemical information	information provided by: webbook.nist.gov (external link)
commonly used hormone	nandrolone phenylpropionate is a commonly used hormone to promote protein anabolism, alias: nandrolone propionate, positive for male ketones, phenylpropionic acid demethyltestosterone, doloron, dolorin. It is prepared by esterification of 19-nortestosterone with phenylalyl chloride. The dosage form is an oily injection, which is administered by intramuscular injection. Can promote protein synthesis and calcium, phosphorus, potassium accumulation, for severe osteoporosis, premature infants, growth retardation, dwarfism, severe malnutrition, etc.; Can also be used for non-operable breast cancer, dysfunctional uterine bleeding, myoma of uterus, etc. But this product can have mild virilizing effect; Not long-term use; Prostate cancer, high blood pressure, pregnant women are not used; Heart, liver and kidney dysfunction with caution.
physical and chemical properties	White or milky white crystalline powder with special odor. Melting point 95~99 ℃, relative density 1.14g/cm3,[α]D20 48~51 ℃ (dioxane). Soluble in ethanol, tea oil, slightly soluble in vegetable oil; Almost insoluble in water.
pharmacological effects	the protein assimilation effect of this product is 12 times that of testosterone propionate, and the androgen activity is relatively small, for the latter 1.5 times, can promote protein synthesis and inhibition of protein heterogenesis, and make calcium and phosphorus deposition and promote the role of bone tissue growth. Its intramuscular injection can be maintained for 1 to 2 weeks.
pharmacokinetics	metabolism: hormones are excreted in the urine, mostly in conjugated form, whereas in feces the hormone is mainly excreted in free form, the main metabolite of nandrolone and norandrostenediol in urine is 19-norandrosterone (19-na).
indications	dermatology is used as an adjunctive therapy for the negative nitrogen balance caused by high-dose corticosteroids, while increasing dietary protein; also used for exfoliative dermatitis, pemphigus, Dermatomyositis, scleroderma, senile skin pruritus. In addition, severe burns, malignant tumors before and after surgery, after fracture is not easy to heal and severe osteoporosis, premature infants, significant growth retardation, dwarfism, severe malnutrition, loss of appetite, chronic diarrhea and other serious consumptive diseases, this product can be given at the same time as other treatments. Inoperable breast cancer can relieve symptoms, functional uterine bleeding, uterine fibroids can be applied.
function and use	is an anabolic hormone, the main function is to promote protein synthesis, inhibit protein decomposition, make muscle growth, weight gain, but also can make water, sodium, calcium, phosphorus retention. It is mainly used in clinical cases of insufficient protein synthesis and increased decomposition, such as malnutrition, stunting in children, severe burns, recovery after surgery, fracture healing, osteoporosis and chronic wasting diseases in the elderly (such as chronic liver and kidney disease, advanced malignant tumor, hyperthyroidism and anemia, etc.); It is also used for negative nitrogen balance caused by long-term use of glucocorticoid, but in the medication should increase the protein content of food. This product has a bad odor, almost insoluble in water, soluble in ethanol, fatty oil.
adverse reactions	there is a slight virilizing effect. Women may have hirsutism, acne, voice thickening, and enlarged vulva, amenorrhea or menstrual disorders. If it occurs, the drug should be discontinued immediately. Long-term use can cause jaundice and liver dysfunction. Edema may also occur due to water and sodium retention.
drug interaction
note	(1) liver disease, kidney disease, hypertension, prostate cancer, breast cancer and pregnant women should not be used. (2) healthy children should not use. (3) patients with benign prostatic hypertrophy, myocardial infarction or a history of coronary atherosclerosis should be used with caution. (4) This product is strictly prohibited as nutrition products for long-term application in normal people. (5) nutrition, especially protein, should be increased during administration. (6) deep intramuscular injection was needed.
Use	for the treatment of stunting, malnutrition, and wasting disorders.

Last Update：2024-04-09 21:04:16

Shanghai Worldyang Chemical Co.,Ltd.

NANDROLONE PHENPROPIONATE

nandrolone 3-phenylpropionate

CAS: 62-90-8

Molecular Formula: C27H34O3

NANDROLONE PHENPROPIONATE - Names and Identifiers

NANDROLONE PHENPROPIONATE - Physico-chemical Properties

NANDROLONE PHENPROPIONATE - Risk and Safety

NANDROLONE PHENPROPIONATE - Standard

Authoritative Data Verified Data

NANDROLONE PHENPROPIONATE - Trait

Authoritative Data Verified Data

melting point

specific rotation

NANDROLONE PHENPROPIONATE - Differential diagnosis

Authoritative Data Verified Data

NANDROLONE PHENPROPIONATE - Exam

Authoritative Data Verified Data

Related substances

loss on drying

NANDROLONE PHENPROPIONATE - Content determination

Authoritative Data Verified Data

chromatographic conditions and system suitability test

assay

NANDROLONE PHENPROPIONATE - Category

Authoritative Data Verified Data

NANDROLONE PHENPROPIONATE - Storage

Authoritative Data Verified Data

NANDROLONE PHENPROPIONATE - Nandrolone Phenylpropionate Injection

Authoritative Data Verified Data

trait

identification

examination

Content determination

category

specification

storage

NANDROLONE PHENPROPIONATE - Reference Information

Supplier List

NANDROLONE PHENPROPIONATE Request for Quotation

nandrolone 3-phenylpropionate

CAS: 62-90-8

Molecular Formula: C27H34O3

NANDROLONE PHENPROPIONATE - Names and Identifiers

NANDROLONE PHENPROPIONATE - Physico-chemical Properties

NANDROLONE PHENPROPIONATE - Risk and Safety

NANDROLONE PHENPROPIONATE - Standard

Authoritative Data Verified Data

NANDROLONE PHENPROPIONATE - Trait

Authoritative Data Verified Data

melting point

specific rotation

NANDROLONE PHENPROPIONATE - Differential diagnosis

Authoritative Data Verified Data

NANDROLONE PHENPROPIONATE - Exam

Authoritative Data Verified Data

Related substances

loss on drying

NANDROLONE PHENPROPIONATE - Content determination

Authoritative Data Verified Data

chromatographic conditions and system suitability test

assay

NANDROLONE PHENPROPIONATE - Category

Authoritative Data Verified Data

NANDROLONE PHENPROPIONATE - Storage

Authoritative Data Verified Data

NANDROLONE PHENPROPIONATE - Nandrolone Phenylpropionate Injection

Authoritative Data Verified Data

trait

identification

examination

Content determination

category

specification

storage

NANDROLONE PHENPROPIONATE - Reference Information

Supplier List

NANDROLONE PHENPROPIONATE