NEUROMEDIN B (HUMAN, PORCINE, RAT)
Neuromedin B
CAS: 87096-84-2
Molecular Formula: C52H73N15O12S
NEUROMEDIN B (HUMAN, PORCINE, RAT) - Names and Identifiers
NEUROMEDIN B (HUMAN, PORCINE, RAT) - Physico-chemical Properties
| Molecular Formula | C52H73N15O12S |
| Molar Mass | 1132.29 |
| Storage Condition | −20°C |
| MDL | MFCD00167607 |
| In vitro study | Potency to stimulate contraction of rat uterine smooth muscle, that is used as bioassay for isolation of Neuromedin B (NMB), is compared with Bombesin (BN). The relative potency, calculated on molar basis by taking BN as 100, is 48% for GRP and 4.9% for NMB. NMB also has contractile activity on rat stomach strip, but the potency (ratio of peptide concentration required to elicit 50% maximum response; EC 50 ) is only 5% of BN (EC 50 of BN/EC 50 of NMB) and about 10% of GRP (EC 50 of GRP/ EC 50 of NMB). |
| In vivo study | Potencies of NMB and GRP for smooth muscle contraction of fundus in wild-type and NMB-R-deficient mice with ED 50 of 14.4±2.3 (n=8) and 10.9±2.3 (n=8) in wild-type mice and NMB-R-deficient mice, respectively. |
NEUROMEDIN B (HUMAN, PORCINE, RAT) - Risk and Safety
| WGK Germany | 3 |
NEUROMEDIN B (HUMAN, PORCINE, RAT) - Reference Information
| Biological activity | Neuromedin B is a neuropeptide containing 10 amino acids, belonging to the frog peptide family, and is a bombesin-related peptide. |
| target | Human Endogenous Metabolite |
| in vitro research | Potency to stimulate contraction of rat uterine smooth muscle, that is used as bioassay for isolation of Neuromedin B (NMB), is compared with Bombesin (BN). The relative potency, calculated on solar based by taking BN as 100, is 48% for GRP and 4.9% for NMB. NMB also has contractile activity on rat stomach strip, but the potency (ratio of peptide concentration required to elicit 50% maximum response; EC 50 ) is only 5% of BN (EC 50 of BN/EC 50 of NMB) and about 10% of GRP (EC 50 of GRP/ EC 50 of NMB). |
| in vivo research | Potencies of NMB and GRP for smooth muscle contraction of fundus in wild-type and NMB-R-deficient mice with ed 50 of 14.4±2.3 (n = 8) and 10.9±2.3 (n = 8) in wild-type mice and NMB-R-deficient mice, respectively. |
Last Update：2024-04-09 20:13:35
