NSC 201423 NSC 204985 Sterigmatocystin
Sterigmatocystin
CAS: 10048-13-2
Molecular Formula: C18H12O6
NSC 201423 NSC 204985 Sterigmatocystin - Names and Identifiers
NSC 201423 NSC 204985 Sterigmatocystin - Physico-chemical Properties
| Molecular Formula | C18H12O6 |
| Molar Mass | 324.28 |
| Density | 1.2842 (rough estimate) |
| Melting Point | 249-251℃ |
| Boling Point | 382.63°C (rough estimate) |
| Flash Point | 6℃ |
| Appearance | Pale yellow lens powder |
| Color | yellow |
| BRN | 53259 |
| pKa | 6.92±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.4800 (estimate) |
| MDL | MFCD00005084 |
| In vitro study | Sterigmatocystine-induced DNA damage activates the ATM/53-dependent signaling pathway, which contributes to the induction of G2 arrest in GES-1 cells. |
| In vivo study | Sterigmatocystine (ip; 3 mg/kg once daily for 14 days) inhibits p21 WAF1/CIP1 . |
NSC 201423 NSC 204985 Sterigmatocystin - Risk and Safety
| Risk Codes | R25 - Toxic if swallowed R40 - Limited evidence of a carcinogenic effect R36 - Irritating to the eyes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S16 - Keep away from sources of ignition. |
| UN IDs | UN 3462 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | LV1750000 |
| FLUKA BRAND F CODES | 10 |
| HS Code | 29329990 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
NSC 201423 NSC 204985 Sterigmatocystin - Reference
| Reference Show more | 1. Tao Chen, Yuanhong Xu, Shuang Wei, Aihua Li, Lei Huang, Jingquan Liu,A signal amplification system constructed by bi-enzymes and bi-nanospheres for sensitive detection of norepinephrine and miRNA,Biosensors and Bioelectronics,Volumes 124–125,2019,Page |
NSC 201423 NSC 204985 Sterigmatocystin - Reference Information
| (IARC) carcinogen classification | 2B (Vol. 10, Sup 7) 1987 |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| overview | treponin is also called sterigmatocystin. sterigmatocystin (Sterigmatocystin,ST) is a carcinogenic and teratogenic mycotoxin and a synthetic precursor of aflatoxin (Aflatoxin,AFT). Both have similar structures and are composed of difuran ring and oxanthraquinone. ST is a type 2B carcinogen classified by the International Agency for Research on Cancer, which is closely related to lung cancer, liver cancer and gastric cancer. |
| properties | sterigretin (Sterigmatocys for short ST) is a heterocyclic compound with strong liver and kidney toxins, which can induce a variety of tumors. The high incidence of liver cancer in some parts of South Africa may be related to ST. Trichosycetin is, can cause cholangiocarcinoma and liver cancer, mutagenicity, but the frequency of contamination of food is low. ST can also be converted into aflatoxin, a more intense carcinogen. ST can also cause some animal diseases. |
| Biological activity | Sterigmatocystine is the precursor of aflatoxin and a mycotic produced by Aspergillus versicolor. Sterigmatocystine is an inhibitor of G1 phase and DNA synthesis and is used to inhibit p21 activity. Sterigmatocystine has teratogenic and carcinogenic effects on animal development. |
| category | toxic substances |
| toxicity classification | highly toxic |
| acute toxicity | oral-rat LD50 120 mg/kg; Oral-mouse LD50: > 800 mg/kg |
| flammability hazard characteristics | combustible, spicy and irritating smoke from the fire site |
| storage and transportation characteristics | warehouse is low temperature, ventilated and dry; Store separately from food raw materials |
| fire extinguishing agent | water, carbon dioxide, foam, sand |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 19:05:11
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