NSC 677
5-phenyl-1,3,4-thiadiazol-2-amine
CAS: 2002-03-1;312619-47-9
Molecular Formula: C8H7N3S
NSC 677 - Names and Identifiers
| Name | 5-phenyl-1,3,4-thiadiazol-2-amine |
| Synonyms | NSC 677 2-Amino-5-phenyl-1,3,4-thiazole 5-Phenyl-1,3,4-thiadiazol-2-amin 5-Phenyl-1,3,4-thiadiazol-2-amine 5-phenyl-1,3,4-thiadiazol-2-amine 5-Phenyl-1,3,4-thiadiazole-2-amine 5-Phenyl-2-amino-1,3,4-thiadiazole 1,3,4-thiadiazol-2-amine, 5-phenyl- 1,3,4-Thiadiazol-2-amine, 5-phenyl- 2-AMINO-5-PHENYL-1 3 4-THIADIAZOLE 96 5-phenyl-1,3,4-thiadiazol-2-amine sulfate |
| CAS | 2002-03-1 312619-47-9 |
| InChI | InChI=1/C8H7N3S.H2O4S/c9-8-11-10-7(12-8)6-4-2-1-3-5-6;1-5(2,3)4/h1-5H,(H2,9,11);(H2,1,2,3,4) |
NSC 677 - Physico-chemical Properties
| Molecular Formula | C8H7N3S |
| Molar Mass | 177.23 |
| Density | 1.333±0.06 g/cm3(Predicted) |
| Melting Point | 223-227°C(lit.) |
| Boling Point | 359.0±25.0 °C(Predicted) |
| Flash Point | 298.4°C |
| Vapor Presure | 8.05E-14mmHg at 25°C |
| Maximum wavelength(λmax) | 267nm(H2SO4 aq.)(lit.) |
| pKa | 2.90±0.10(Predicted) |
| Storage Condition | Room Temprature |
NSC 677 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
NSC 677 - Introduction
5-phenyl-1,3,4-thiadiazol-2-amine is an organic compound with the chemical formula C11H9N3S. The following is a description of its nature, use, preparation and safety information:
Nature:
5-phenyl-1,3,4-thiadiazol-2-amine is a colorless crystalline solid, insoluble in water, but soluble in some organic solvents such as ethanol and dimethyl sulfoxide. It has a moderate melting point and low volatility.
Use:
5-phenyl-1,3,4-thiadiazol-2-amine has certain application value in the field of medicine. It is used as a pharmaceutical intermediate and can be used to synthesize some anti-tumor, antibacterial, anti-inflammatory and other drugs. In addition, it can also be used as a precursor of dyes and used in the field of dyeing.
Method:
The preparation method of 5-phenyl-1,3,4-thiadiazol-2-amine mainly includes two-step reaction. First, Aniline reacts with hypochlorous acid under acid catalysis to form an imine intermediate. The imine intermediate is then reacted with a thiol to produce 5-phenyl-l, 3,4-thiadiazol-2-amine. During the reaction, attention should be paid to the operating temperature and waste treatment to ensure safety.
Safety Information:
5-phenyl-1,3,4-thiadiazol-2-amine is relatively safe under correct use and storage conditions. However, it may be irritating and corrosive to the eyes and skin, and direct contact should be avoided. During operation, appropriate protective measures should be taken, such as wearing safety glasses, gloves and protective clothing. If accidentally inhaled or ingested, seek medical help immediately.
Nature:
5-phenyl-1,3,4-thiadiazol-2-amine is a colorless crystalline solid, insoluble in water, but soluble in some organic solvents such as ethanol and dimethyl sulfoxide. It has a moderate melting point and low volatility.
Use:
5-phenyl-1,3,4-thiadiazol-2-amine has certain application value in the field of medicine. It is used as a pharmaceutical intermediate and can be used to synthesize some anti-tumor, antibacterial, anti-inflammatory and other drugs. In addition, it can also be used as a precursor of dyes and used in the field of dyeing.
Method:
The preparation method of 5-phenyl-1,3,4-thiadiazol-2-amine mainly includes two-step reaction. First, Aniline reacts with hypochlorous acid under acid catalysis to form an imine intermediate. The imine intermediate is then reacted with a thiol to produce 5-phenyl-l, 3,4-thiadiazol-2-amine. During the reaction, attention should be paid to the operating temperature and waste treatment to ensure safety.
Safety Information:
5-phenyl-1,3,4-thiadiazol-2-amine is relatively safe under correct use and storage conditions. However, it may be irritating and corrosive to the eyes and skin, and direct contact should be avoided. During operation, appropriate protective measures should be taken, such as wearing safety glasses, gloves and protective clothing. If accidentally inhaled or ingested, seek medical help immediately.
Last Update：2024-04-09 21:01:54
Supplier List
Multiple Specifications
Product Name: 2-AMINO-5-PHENYL-1 3 4-THIADIAZOLE Visit Supplier Webpage Request for quotationCAS: 312619-47-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Multiple Specifications
Product Name: 2-AMINO-5-PHENYL-1 3 4-THIADIAZOLE Visit Supplier Webpage Request for quotationCAS: 312619-47-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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