Noradrenaline Bitartrate
(R)-(-)-norepinephrine L-bitartrate monohydrate
CAS: 108341-18-0;69815-49-2
Molecular Formula: C12H17NO9
Noradrenaline Bitartrate - Names and Identifiers
| Name | (R)-(-)-norepinephrine L-bitartrate monohydrate |
| Synonyms | L-ARTERENOL BITARTRATE Noradrenaline Bitartrate L-NORADRENALINE BITARTRATE L-NOREPINEPHRINE BITARTRATE L-Arterenol hydrogen L-tartrate (-)-arterenol bitartrate hydrate L-Norepinephrine bitartrate salt Levarterenol bitartrate monohydrate L-(-)-NOREPINEPHRINE-(+)-BITARTRATE Noradrenaline Bitartrate monohydrate norepinephrine hydrogen tartrate monohydrate (R)-()-Norepinephrine L-bitartrate monohydrate (R)-(-)-norepinephrine L-bitartrate monohydrate norepinephrine bitartrate monohydrate*200 mg per L-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol bitartrate 4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol 2,3-dihydroxybutanedioate hydrate (salt) |
| CAS | 108341-18-0 69815-49-2 |
| EINECS | 627-941-5 |
| InChI | InChI=1/C8H11NO3.C4H6O6.H2O/c9-4-8(12)5-1-2-6(10)7(11)3-5;5-1(3(7)8)2(6)4(9)10;/h1-3,8,10-12H,4,9H2;1-2,5-6H,(H,7,8)(H,9,10);1H2/t8-;1-,2-;/m01./s1 |
Noradrenaline Bitartrate - Physico-chemical Properties
| Molecular Formula | C12H17NO9 |
| Molar Mass | 319.27 |
| Melting Point | 100-104°C(lit.) |
| Boling Point | 442.6°C at 760 mmHg |
| Specific Rotation(α) | -11 ° (C=5, H2O) |
| Flash Point | 221.5°C |
| Solubility | H2O : 50 mg/mL (148.24 mM; Need ultrasonic);DMSO : ≥ 30 mg/mL (88.95 mM) |
| Vapor Presure | 1.3E-08mmHg at 25°C |
| Appearance | White to off-white (Solid) |
| Color | white |
| BRN | 4078502 |
| pKa | 8.64(at 25℃) |
| Storage Condition | Refrigerator |
| Sensitive | Sensitive to light |
| Refractive Index | -11 ° (C=5, H2O) |
| MDL | MFCD00150449 |
| Use | Adrenoceptor hormone drugs. |
| In vitro study | Noradrenaline modulates the acquisition of evoked activity, in particular in the sense of the senses. Noradrenaline promotes long-term synaptic plasticity, in addition to these data highlighting its short-term effects. Norepinephrine signals that "changes in the Total Environment produce sensory information that is strongly contrary to top-down expectations", and will be through the "bottom-up" information processing in the irrelevant "top-down" of the expected expenditure increase, is conducive to the adjustment of the behavior. Noradrenaline regulates drive and energy and exerts precise regulatory effects, including learning, memory, sleep, wakefulness and adaptation. The Noradrenaline system is closely involved in a series of psychological processes, this system disorder leads to the classification of Mental Disorder of manifestations. Noradrenaline appears to be involved in a range of psychological processes, including wakefulness (alertness), cognition, learning, and sleep regulation, and is also regulating responses to stress that may trigger or exacerbate depressive symptoms. In this pathway Noradrenaline deficiency can reduce concentrations, affect working memory and cause psychomotor retardation, leading to apathy and depression, while this pathway increases Noradrenaline expected to relieve inattention, apathy and depression. The effects of Noradrenaline are complex and depend on experimental conditions (pons and medulla oblongata preparations) and species (rat or mouse), exogenous Noradrenaline and a mixture with Alpha 1 facilitation and Alpha 2 inhibition are primarily promoting or inhibiting primarily neonatal RRG. |
Noradrenaline Bitartrate - Risk and Safety
| Hazard Symbols | T+ - Very toxic |
| Risk Codes | R26/27/28 - Very toxic by inhalation, in contact with skin and if swallowed. R28 - Very Toxic if swallowed |
| Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S28 - After contact with skin, wash immediately with plenty of soap-suds. |
| UN IDs | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | DN6750000 |
| HS Code | 2937901500 |
| Hazard Class | 6.1 |
| Packing Group | III |
Noradrenaline Bitartrate - Standard
Authoritative Data Verified Data
This product is (R)-4-(2-amino + hydroxyethyl)-l, 2-benzenediol bitartrate monohydrate. Calculated as anhydrous, containing no less than 99.0% of C8H11N03 • C4H606.
Last Update：2024-01-02 23:10:35
Noradrenaline Bitartrate - Trait
Authoritative Data Verified Data
- This product is white or off-white crystalline powder; Odorless; Easy to deteriorate when exposed to light and air.
- This product is soluble in water, slightly soluble in ethanol, insoluble in chloroform or ether.
melting point
The melting point of this product (General rule 0612) is 100~106°C, which is decomposed at the same time during melting and becomes turbid.
specific rotation
take this product, precision weighing, add water to dissolve and quantitatively dilute to make a solution containing about 50mg per lml, and determine according to law (General 0621), the specific rotation was -10.0 ° to -12.0 °.
Last Update：2022-01-01 13:43:00
Noradrenaline Bitartrate - Introduction
Noradrenaline bitartrate monohydrate is a direct alpha-adrenergic receptor agonist.
Last Update：2022-10-16 17:11:57
Noradrenaline Bitartrate - Differential diagnosis
Authoritative Data Verified Data
- take about 10m g of this product, add 1 ml of water to dissolve, add 1 drop of ferric chloride test solution, shake, then show the green color; Slowly add sodium bicarbonate test solution, then show the blue color, finally turned red.
- take about 1 mg of this product, add 10ml of saturated solution of potassium hydrogen tartrate to dissolve, add 1ml of Iodine test solution, place it for 5 minutes, add 2ml of sodium thiosulfate test solution, the solution was colorless or only microscopic red or light purple (distinguished from epinephrine or isoproterenol).
- take about 50mg of this product, add 1 ml of water to dissolve, add 1 ml of 10% potassium chloride solution, and precipitate crystalline precipitate within 10 minutes.
Last Update：2022-01-01 13:43:00
Noradrenaline Bitartrate - Exam
Authoritative Data Verified Data
clarity and color of solution
take the solution under the item of specific rotation to check, should be clear and colorless.
ketone body
take this product, add water to dissolve and dilute to make about 2.0 mg solution, according to UV visible spectrophotometry (General rule 0401), measured at a wavelength of 0.05 NM, absorbance should not exceed.
Related substances
take this product, add mobile phase A to dissolve and dilute to make A solution containing about 5mg per lml, as A test solution; Take appropriate amount with precision, A solution containing about 15ug per 1 ml was prepared as A control solution by quantitative dilution with mobile phase A. Test according to high performance liquid chromatography (General 0512). Silica gel bonded with eighteen alkyl silane was used as filler, and 0.05% sodium heptane sulfonate solution (adjusted to pH 2.2 with phosphoric acid) was used as mobile phase A; Acetonitrile-0.05% sodium heptane sulfonate solution (1:1) mobile Phase B (pH adjusted to 2.4 with phosphoric acid), gradient elution was carried out according to the following table; Detection wavelength was 280nm; Flow rate was 1.5 per minute. Take this product lOmg, add 0.1 mol/L hydrochloric acid solution 5ml to dissolve, take 1 ml, add concentrated hydrogen peroxide solution 0.1 mL, shake well, irradiate under UV lamp (254nm) for 90 minutes, add mobile Phase 9ml, shake well, as the system applicable solution, take 20u1 injection liquid chromatograph, the retention time of the main component peak is about 11 minutes, the main component peak should appear after an unknown degradation product peak and the peak of, the relative retention time of noradrenone peak is about 1.3, and the separation degree of main component peak and adjacent impurity peak should meet the requirements. 20ul of the test solution and the control solution were respectively injected into the liquid chromatograph, and the chromatograms were recorded. If there is a peak in the chromatogram of the test solution that is consistent with the retention time of the peak of the noradrenone, the peak area multiplied by 0.3 shall not be greater than 0.1% of the main peak area of the control solution, the Peak area of other individual impurities shall not be greater than 0.1% (0.3%) of the main peak area of the control solution; The total amount of impurities shall not exceed. The chromatogram of the test solution is 1/6 times smaller than the main peak area of the control solution.
moisture
take this product 50mg, according to the moisture determination method (General 0832 first method 1), the moisture should be 5.0% ~ 6.0%.
ignition residue
not more than 0.1% (General rule 0841).
Last Update：2022-01-01 13:43:01
Noradrenaline Bitartrate - Content determination
Authoritative Data Verified Data
take 0.2g of this product, precision weighing, Add 10ml of glacial acetic acid, shake (if necessary, slightly warm) to dissolve, add 1 drop of crystal violet indicator solution, and use perchloric acid titration solution (0.1 mol/L) titration to the solution is blue-green, and the result of the titration is corrected with a blank test. Per 1 ml perchloric acid titrant (0.1 mol/L) corresponds to 31.93mg of C8H11N03 • C4H606.
Last Update：2022-01-01 13:43:02
Noradrenaline Bitartrate - Category
Authoritative Data Verified Data
adrenergic receptor agonists.
Last Update：2022-01-01 13:43:02
Noradrenaline Bitartrate - Storage
Authoritative Data Verified Data
shading, filled with inert gas, sealed and stored.
Last Update：2022-01-01 13:43:02
Noradrenaline Bitartrate - Norepinephrine Bitartrate Injection
Authoritative Data Verified Data
- This product is an isotonic sterile aqueous solution containing noradrenaline Bitartrate and an appropriate amount of sodium aerated. Containing norepinephrine bitartrate (C8H11N03 • C4H606 • H20) shall be between 90.0% and 115.0% of the indicated amount.
- suitable stabilizer can be added to this product.
trait
This product is a colorless or almost colorless clear liquid; It is easy to deteriorate when exposed to light and air.
identification
- take 1ml of this product, add 1 drop of ferric chloride test solution, it is green.
- take an appropriate amount of this product (about equivalent to norepinephrine bitartrate 1), and show the same reaction according to the identification (2) test under the item of norepinephrine bitartrate.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
examination
- the pH value should be 2.5 to 4.5 (General 0631).
- Related substances take this product as the test solution; Take 1 ml of the test solution for precision measurement and put it in a 100ml measuring flask, the mixture was diluted to the scale with the mobile phase A under the item of norepinephrine bitartrate related substances, and was shaken to obtain A control solution. According to the determination method under the item of norepinephrine bitartrate related substances, if there is a chromatographic peak in the chromatogram of the test solution that is consistent with the retention time of the peak of norepinephrine, the peak area multiplied by 0.3 shall not be greater than 0.5 times (0.5%) of the main peak area of the control solution; The chromatographic peak before the relative retention time of about 0.3 is excluded, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (1.0%). The chromatogram of the test solution is 0.05 times smaller than the main peak area of the control solution.
- osmolality the osmolality shall be 0632-315mOsmol/kg for determination according to law (General rule 257).
- bacterial endotoxin this product, according to the law to check (General 1143), each 1 mg of norepinephrine bitartrate containing endotoxin should be less than 83EU.
- others should comply with the relevant provisions under injection (General 0102).
Content determination
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; 0.14% sodium heptane sulfonate solution-methanol (65:35)(pH adjusted to 3.0±0.1 with phosphoric acid) mobile phase; The detection wavelength was 280nm. The number of theoretical plates is not less than 3000 based on the norepinephrine peak.
- determination precision: take an appropriate amount of this product (about 4mg equivalent to norepinephrine bitartrate), put it in a 25ml measuring flask, dilute it to the scale with 4% acetic acid solution, and shake it well, as the sample solution, 20 u1 was accurately measured and injected into the liquid chromatograph to record the chromatogram, A solution containing 0.16mg per 1 ml was prepared by adding 4% acetic acid solution and determined by the same method. According to the external standard method to calculate the peak area, that is.
category
noradrenaline bitartrate.
specification
(l ) lml:2mg ( 2 ) lml:5m g (3 )2ml:lOmg
storage
shade, close, and store in a cool place.
Last Update：2022-01-01 13:43:03
Noradrenaline Bitartrate - Reference Information
| Biological activity | Noradrenaline bitartrate monohydrate (Levophed) is a direct α-adrenergic receptor agonist. |
| target | TargetValue alpha-adrenergic receptor |
| Target | Value |
| In vitro studies | Noradrenaline regulate the acquisition of evoked activity, especially in sensory aspects. Noradrenaline promote long-term synaptic plasticity, except that these data emphasize its short-term effects. Norepinephrine signifies that "changes in the total environment generate sensory information that strongly violates top-down expectations", and will be processed through "bottom-up" information in an unrelated "top-down" expected expenditure increase, which is conducive to behavioral adjustment. Noradrenaline regulates drive and energy, and plays a precise regulatory role, including learning, memory, sleep, awakening and adaptation. The Noradrenaline system is closely involved in a series of psychological processes. This system disorder leads to the manifestation of classified mental disorders. Noradrenaline seem to be involved in a series of psychological processes, including awakening (alertness), cognition, learning and sleep regulation, and are also regulating stress in response to which depressive symptoms may be triggered or aggravated. Lack of Noradrenaline in this pathway can reduce concentration, affect working memory and cause psychomotor retardation, leading to apathy and depression, while increased Noradrenaline in this pathway is expected to relieve inattention, apathy and depression. Noradrenaline effects are complex and depend on experimental conditions (pons and medulla oblongata preparations) and species (rats or mice), exogenous Noradrenaline and mixtures with α1 facilitation and α2 inhibition are mainly promoted or inhibited by neonatal RRG. |
| use | adrenergic receptor hormone drugs. adrenergic neurotransmitter (Adrenergic neurotransmitter), vasoconstrictor (vasoconstrictor). L-(−)-Norepinephrine ( )-bitartrate salt |
Last Update：2024-04-09 20:52:54
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Product Name: (R)-(-)-norepinephrine L-bitartrate monohydrate Request for quotation
CAS: 69815-49-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 69815-49-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Multiple SpecificationsSpot supply
Product Name: Noradrenaline bitartrate monohydrate Visit Supplier Webpage Request for quotationCAS: 108341-18-0
Tel: 18301782025
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Mobile: 18021002903
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