O-(5,6,7,8-tetrahydronaphthalen-2-yl) (6-methoxypyridin-2-yl)methylcarbamothioate
Liranaftate
CAS: 88678-31-3
Molecular Formula: C18H20N2O2S
O-(5,6,7,8-tetrahydronaphthalen-2-yl) (6-methoxypyridin-2-yl)methylcarbamothioate - Names and Identifiers
| Name | Liranaftate |
| Synonyms | 88678-31-3 Liranaftate O-(5,6,7,8-tetrahydronaphthalen-2-yl) (6-methoxypyridin-2-yl)methylcarbamothioate N-(6-methoxy-2-Pyridyl)-N-methylthiocarbamic acid O-(5,6,7,8-tetrahydro-2-naphthyl)ester |
| CAS | 88678-31-3 |
| InChI | InChI=1/C18H20N2O2S/c1-20(16-8-5-9-17(19-16)21-2)18(23)22-15-11-10-13-6-3-4-7-14(13)12-15/h5,8-12H,3-4,6-7H2,1-2H3 |
O-(5,6,7,8-tetrahydronaphthalen-2-yl) (6-methoxypyridin-2-yl)methylcarbamothioate - Physico-chemical Properties
| Molecular Formula | C18H20N2O2S |
| Density | 1.24g/cm3 |
| Melting Point | 98.5-99.5ºC |
| Boling Point | 462.5°C at 760 mmHg |
| Flash Point | 233.5°C |
| Solubility | It is soluble in acetone and chloroform, slightly soluble in methanol and ethanol, and almost insoluble in water |
| Vapor Presure | 9.84E-09mmHg at 25°C |
| Appearance | White crystalline solid |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.641 |
| MDL | MFCD00865576 |
| Use | Broad-spectrum antifungal agents |
O-(5,6,7,8-tetrahydronaphthalen-2-yl) (6-methoxypyridin-2-yl)methylcarbamothioate - Nature
Open Data Verified Data
white to yellowish crystalline powder; Odorless, tasteless. Melting point 98. 5~99.5 °c. It is soluble in acetone and chloroform, slightly soluble in methanol and ethanol, and almost insoluble in water.
Last Update：2024-01-02 23:10:35
O-(5,6,7,8-tetrahydronaphthalen-2-yl) (6-methoxypyridin-2-yl)methylcarbamothioate - Preparation Method
Open Data Verified Data
tetralin chloroformate was dissolved in acetonitrile, 2-methylamino-6-methoxypyridine and potassium carbonate were added, and the mixture was stirred at room temperature to obtain the product.
Last Update：2022-01-01 09:08:44
O-(5,6,7,8-tetrahydronaphthalen-2-yl) (6-methoxypyridin-2-yl)methylcarbamothioate - Use
Open Data Verified Data
developed jointly by Tosoh Corporation, Inc., Japan, and Zenyaku kogino, Inc., was first launched in Japan by Torii on 12 August 2000. This product is a squalene cyclooxygenase inhibitor antifungal drug, similar in structure to tolnaphthate, belonging to thiocarbamates. By inhibiting the thirty-hexene epoxidation reaction of fungal cells, the synthesis of ergosterol, a component of cell membrane, is inhibited to exert its antifungal effect. It is used for superficial skin fungal infections, including Tinea corporis, tinea cruris, tinea pedis, tinea pedis, tinea versicolor, and the like, and is also particularly effective against Trichophyton genus (MIC<0.5mglmL), Microsporum genus, and epidermal ringworm. In addition, it has good activity against some pathogenic yeast. Cryptococcus neoformans was also sensitive to the drug.
Last Update：2022-01-01 09:08:45
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Multiple SpecificationsSpot supply
Product Name: Liranaftate Visit Supplier Webpage Request for quotationCAS: 88678-31-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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