Molecular Formula | C16H22O4 |
Molar Mass | 278.34 |
Density | 1.043 g/mL at 25 °C (lit.) |
Melting Point | -35 °C (lit.) |
Boling Point | 340 °C (lit.) |
Flash Point | 340°F |
Water Solubility | Slightly soluble. 0.0013 g/100 mL |
Solubility | Soluble in water (0.4 mg/ml at 20 °C), ethanol. Very soluble in ether, acetone, and B |
Vapor Presure | 1 mm Hg ( 147 °C) |
Vapor Density | 9.6 (vs air) |
Appearance | Colorless liquid |
Specific Gravity | 1.049 (20/20℃) |
Color | APHA: ≤10 |
Exposure Limit | NIOSH REL: TWA 5 mg/m3, IDLH 4,000 mg/m3; OSHA PEL: TWA5 mg/m3; ACGIH TLV: TWA 5 mg/m3. |
Merck | 14,3035 |
BRN | 1914064 |
Storage Condition | 2-8°C |
Sensitive | Easily absorbing moisture |
Explosive Limit | 0.47%, 236°F |
Refractive Index | n20/D 1.492(lit.) |
MDL | MFCD00009441 |
Physical and Chemical Properties | properties colorless oily liquid |
Use | Mainly used as nitrocellulose, cellulose acetate, polyvinyl chloride and other plasticizers; General Chemical analysis reagents for gas chromatography stationary liquid; Used as solvents, pesticides, plasticizers |
Risk Codes | R61 - May cause harm to the unborn child R50 - Very Toxic to aquatic organisms R62 - Possible risk of impaired fertility R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
Safety Description | S53 - Avoid exposure - obtain special instructions before use. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. |
UN IDs | UN 3082 9/PG 3 |
WGK Germany | 2 |
RTECS | TI0875000 |
TSCA | Yes |
HS Code | 29173100 |
Hazard Class | 9 |
Packing Group | III |
Toxicity | Acute oral LD50 for rats 8,000 mg/kg (RTECS, 1985). |
Reference Show more | 1. [IF=2.329] Dong Tian et al."Characterization of Farfarae Flos by Proton Nuclear Magnetic Resonance Fingerprinting and Chemometrics."Anal Lett. 2015;48(1):127-136 2. [IF=7.963] Ming Li et al."Sensitive and selective determination of butyl benzyl phthalate from environmental samples using an enzyme immunoassay."Sci Total Environ. 2019 Oct;687:849 |
Dibutyl phthalate (DBP) is the most commonly used plasticizer for polyvinyl chloride, which can make the product have good flexibility but poor durability. Stability, flex resistance, adhesion and water resistance are better than other plasticizers. Dibutyl phthalate is commonly used as an additive for adhesives and printing inks. Soluble in a variety of organic solvents, such as alcohols, ethers and benzene. DBP is also used as an ectoparasite.
dibutyl phthalate (DBP) is a kind of excellent plasticizer, is a kind of plasticizer in the largest output and dosage, is a general type. For a variety of resins with good dissolution capacity, used as the main plasticizer, with light color, low toxicity, good electrical properties, low volatility, small odor and low temperature resistance.
but some studies suggest that dibutyl phthalate is an environmental endocrine disruptor, which has a significant interference effect on animal estrogen. Some scholars believe that women absorb too high a dose of phthalate esters, will increase the risk of breast cancer in women, and may endanger their future reproductive system development of male babies.
colorless and transparent oily liquid, slightly aromatic, flammable. The relative density was 1. 045. Freezing point -35 °c. Boiling point 335 °c. Ignition point 202 °c. Flash point 171 °c. Refractive index 4926. The vapor pressure (150 °c) was 146. Heat of vaporization: 284 J/g. Specific heat capacity 1. 79J/(g-°c). Viscosity (25 °c) 16. 3MPa. s. Soluble in common organic solvents and hydrocarbons. 25 ° C in water dissolved 0. 03%, water dissolved in this product 0. 4%.
The esterification reaction was carried out under normal pressure with phthalic anhydride and n-butanol as raw materials and sulfuric acid as catalyst. After completion of the reaction, the reaction was neutralized with alkali and washed with water, followed by dealcoholization and pressure filtration to obtain a finished product.
This product is a plasticizer, non-toxic. Mainly used as polyvinyl chloride plasticizer, can make the product has good flexibility. Because of its relatively low price and good processability, it is widely used in China, almost equivalent to DOP. But its volatility and water extraction is large, and the durability of the product is poor, should gradually limit its use. This product is an excellent plasticizer for nitrocellulose, and has strong gelation ability. For nitrocellulose coating, has excellent softening effect, stability, adhesion. This product can also be used as polyvinyl acetate, alkyd resin, ethyl cellulose, natural and synthetic rubber, and organic glass and plasticizer.
closed operation, strengthen ventilation. Operators must be specially trained and strictly follow the operating procedures. It is recommended that operators wear self-priming filter gas masks (half face mask), chemical safety glasses, anti-virus penetration work clothes and rubber oil-resistant gloves. Stay away from fire and heat source. No smoking is allowed in the workplace. The use of explosion-proof ventilation systems and equipment. Prevent vapor leakage into the workplace air. Avoid contact with oxidants and acids. Handling should be light and light unloading, to prevent packaging and container damage. Fire fighting equipment and emergency treatment equipment for leakage shall be provided with corresponding varieties and quantities. Harmful substances may remain in the empty container.
store in a cool, ventilated warehouse. Keep away from fire and heat source. It should be stored separately from oxidants and acids, and mixed storage should not be avoided. With the corresponding varieties and quantity of fire fighting equipment. The storage area shall be equipped with emergency treatment equipment for leakage and appropriate containment materials.
The Scientific Committee on Health and Environmental Risks (SCHER) of the European Commission concluded on the basis of urine samples of different ages, it is believed that the total exposure of individuals to dibutyl phthalate in the general population is lower than the daily tolerated intake (TDI), and efforts to reduce exposure are only needed in some special populations.
The most sensitive person can smell the threshold concentration of 0.00026mg/L. The threshold concentration of this product on the light reflex of the eye is 0.00016mg/L, and the threshold concentration of the brain bioelectric activity is 0.00011~0.00012mg/L. Plasticizer production workers may suffer from multiple neuritis, spinal neuritis and multiple neuritis of the brain. Effect on skin and eyes: This product can be absorbed by a small amount of intact skin. Skin and eye mucosa after a contact with this product, does not cause irritation, and repeated contact can be seen in severe irritation. According to some experimental data, it can cause mild sensitization.
LD50 = 25mg/L for mice inhaled aerosol for 2 hours. During the poisoning, there was strong irritation to the mucosa of the eye and upper respiratory tract, Dyspnea, ataxia, hind limb paralysis; Some animals presented with superficial anesthesia, clonic convulsion.
This product is also the same as other phthalate esters, can cause functional changes in the central nervous system and peripheral nervous system, and then further cause their organizational changes. Hepatic tropism. Can cause mild sensitization. With a moderate degree of accumulation and mild stimulation.
LD5012000mg/kg (Rat oral);5282 μg/kg (mouse oral);LC507900μg/m3 (rat inhalation);2100 μg/m3 (Mouse Inhalation)
rats were fed for 1.25% × 1 years (feeding). Some animals died in the first week, and no tissue lesion occurred. Human 10g Nausea by mouth, dizziness, lacrimation, photophobia and conjunctivitis.
Overview | Dibutyl phthalate is also known as Dibutyl phthalate or Dibutyl Ester, English: Dibutyl phosphate, colorless and transparent oily liquid, specific gravity 1.045(21 ℃), boiling point 340 ℃, insoluble in water, water-soluble and volatile are very low, but soluble in ethanol, ether, acetone and benzene and other organic solvents can be miscible with most hydrocarbons. Dibutyl phthalate (DBP), dioctyl phthalate (DOP) and diisobutyl phthalate (DIBP) are the three most common plasticizers, which are commonly used in plastics, synthetic rubber and artificial leather. It is prepared by heating esterification of phthalic anhydride and n-butanol. |
reference quality standard | index name high-grade product first-grade product Appearance transparent oily liquid Color (APHA)≤ 20 25 60 Ester content% ≥ 99.5 99.0 99.0 Acidity (as phthalic acid)% ≤ 0.010 0.015 0.030 Heating loss (125oC3 hours)%≤ 0.3 0.5 0.7 Flash point (Open Cup method) oC ≥ 160 160 160 Specific gravity D30MD 1.044-1.048 0.044-0.048 0.044-0.048 |
dibutyl phthalate (DBP) applications and characteristics | This product is a kind of plasticizer with strong dissolving power for many kinds of resins. It is a non-toxic plasticizer used in PVC processing, which can give good flexibility to products. It is used in nitric acid fiber coating and has excellent solubility, dispersibility, adhesion and water resistance. The flexibility, flexibility and stability of the paint film are good. However, the volatility and water extractability are large, and thus the durability is poor. Plastics, synthetic rubber, artificial leather and other commonly used plasticizers, can also be used as polyvinyl acetate, alkyd resin, ethyl cellulose, nitrocellulose, Chloroprene Rubber, fiber butyl acetate, ethyl cellulose polyacetic acid, plasticizers for vinyl esters. It can also be used in the manufacture of paints, standing agents, artificial leather, printing inks, safety glass, cellulite, dyes, pesticide solvents and fixatives, fabric lubricants and rubber softeners. |
safety considerations | DBP pure products closed cup flash point 171°C, Open Cup ignition point 399°C, low toxicity, but for individuals may have a skin irritation. The maximum allowable concentration in the air is 5mg/m3 ~ 0.4ppm(v/v), and the foam and sand carbon dioxide can be used for extinguishing the fire. |
Chemical properties | colorless and transparent oily liquid, with slightly aromatic odor. Soluble in common organic solvents and hydrocarbons. |
purpose | mainly used as nitrocellulose, cellulose acetate, polyvinyl chloride and other plasticizers |
purpose | the product is a plasticizer. It has a strong solubility for a variety of resins. Mainly used in PVC processing, can be given in the product of good flexibility. Because of its relatively low price and good processability, it is widely used in China, and it is equivalent to DOP. However, the volatility and water extraction is large, so the durability of the product is poor, and its use should be gradually limited. The product is a good increase in the plasticity of cellulose nitrate, gel ability. For nitrocellulose coating, there is a good softening effect. Stability, flex resistance, adhesion and water resistance are excellent. In addition, the product can also be used as polyvinyl acetate, alkyd resin, ethyl cellulose and chloroprene rubber plasticizer, can also be used in the manufacture of paints, adhesives, artificial leather, printing ink, safety glass, celluloid, dyes, pesticides, perfume solvents, fabric lubricants, etc. |
purpose | used as stationary liquid, solvent and plasticizer for gas chromatography |
purpose | as cellulose ester, salt and natural rubber, polystyrene plasticizer; Make polyvinyl chloride and its copolymer have cold resistance |
production method | The esterification reaction was carried out at normal pressure using phthalic anhydride and n-butanol as raw materials and sulfuric acid as catalyst. After completion of the reaction, the reaction was neutralized with alkali and washed with water, followed by dealcoholization and pressure filtration to obtain a finished product. There are two kinds of Processing Technology: batch method and continuous method. Raw material consumption quota: phthalic anhydride 540kg/t, butanol (95%)560kg/t. |
category | flammable liquid |
toxicity classification | poisoning |
Acute toxicity | oral-rat LD50: 7499 mg/kg; Oral-mouse LD50: 3484 mg/kg |
explosive hazard characteristics | mixed with air, heated, flame can be broken |
flammability hazard characteristics | in case of open flame, high temperature, strong oxidant flammable; Combustion emission stimulation smoke |
storage and transportation characteristics | complete packaging, Light Light; Warehouse ventilation, away from the open flame, high temperature, and oxidant storage separately |
extinguishing agent | foam, carbon dioxide, dry powder, sand |
Occupational criteria | TLV-TWA 5 mg/m3; Tel 10 mg/m3 |
The use of this substance in cosmetics, including nail polish, is prohibited by EU Directive 768/EEC 1976.
The use of DBP in children's toys has also been restricted since 1999.
DBP has been on the California position 65 (1986) list of suspected teratogens since 11.2006. All major producers have reduced the use of this substance in nail polish from the fall of 2006.
The permanent ban on the use of DBP in children's toys and childcare articles in concentrations exceeding 1000 ppm was established by the Consumer Product Safety Improvement Act of 2008,CPSIA) as specified in section 108.
migration in the environment: for phthalate esters, hydrolysis, volatilization and photolysis are not their important reaction processes. It is estimated that the hydrolysis half-life of phthalate esters varies from 3.2 years for diethyl phthalate to years for 2-ethylhexyl phthalate. Due to their lower vapor pressure, their volatilization loss is small or almost no. Although there are no reports on the photolysis of phthalates, it can be inferred from the phenomenon that there is no spectral absorption in the ultraviolet and visible range that they are difficult to carry out photochemical reactions. Experimental studies have shown that the biological enrichment of phthalate esters, this conclusion is confirmed by the results of field studies, because the experimenter found that aquatic organisms have obvious residues of such compounds.
The former Soviet Union (1975) health standard workshop 0.5mg/m3
The maximum allowable concentration of harmful substances in the atmosphere in residential areas of the former Soviet Union (1975) was 0.1mg/m3 (maximum)
China (GHZB1-1999) surface water environment quality standard (I, II, III waters) 0.003mg/L
China (GB8978-1996) Integrated Wastewater discharge standard
relative polarity | 0.272 |
freezing point | -35 ℃ |
Henry's Law Constant | 6.3 x 10-5 atm?m3/mol (quoted, Petrasek et al., 1983) |
LogP | 4.46-4.57 at 20-30℃ |
NIST chemical information | information provided by: webbook.nist.gov (external link) |
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
Overview | Dibutyl phthalate also known as Dibutyl phthalate or Dibutyl Ester, English: Dibutyl phthlate, is a colorless transparent oily liquid, specific gravity 1.045(21 ° C), boiling point 340 ° C, insoluble in water, water-soluble and volatile are very low, but soluble in ethanol, ether, acetone and benzene and other organic solvents can be miscible with most hydrocarbons. Dibutyl phthalate (DBP), dioctyl phthalate (DOP) and diisobutyl phthalate (DIBP) are the three most common plasticizers, which are commonly used in plastics, synthetic rubber and artificial leather. It is prepared by heating esterification of phthalic anhydride and n-butanol. |
hazard | dibutyl phthalate is an emerging polyvinyl chloride plasticizer commonly used in industrial production, which is easily released into the environment during processing and use, it causes adverse effects such as tissue canceration, developmental malformation, reproductive toxicity and gene mutation. |
reference quality standard | index name high-grade product first-grade product appearance transparent oily liquid color (APHA)≤ 20 25 60 ester content% ≥ 99.5 99.0 99.0 acidity (as phthalic acid)% ≤ 0.010 0.015 0.030 heating loss (125oC3 hours)% ≤ 0.3 0.5 0.7 flash point (Open Cup method) oC ≥ 160 160 160 specific gravity D30MD 1.044-1.048 0.044-0.048 0.044-0.048 |
dibutyl phthalate (DBP) use and characteristics | This product is a variety of resins with a strong dissolution of plasticizers. It is a non-toxic plasticizer used in PVC processing, which can give good flexibility to products. It is used in nitric acid fiber coating and has excellent solubility, dispersibility, adhesion and water resistance. The flexibility, flexibility and stability of the paint film are good. However, the volatility and water extractability are large, and thus the durability is poor. Plastics, synthetic rubber, artificial leather and other commonly used plasticizers, can also be used as polyvinyl acetate, alkyd resin, ethyl cellulose, nitrocellulose, Chloroprene Rubber, fiber butyl acetate, ethyl cellulose polyacetic acid, plasticizers for vinyl esters. It can also be used in the manufacture of paints, standing agents, artificial leather, printing inks, safety glass, cellulite, dyes, pesticide solvents and fixatives, fabric lubricants and rubber softeners. |
safety precautions | the flash point of the closed cup of pure DBP product is 171°C, and the ignition point of the Open Cup is 399°C, with low toxicity, but for an individual, it can be irritating to the skin. The maximum allowable concentration in the air is 5mg/m3 ~ 0.4ppm(v/v), and the foam and sand carbon dioxide can be used for extinguishing the fire. |
purpose | mainly used as plasticizer for nitrocellulose, acetate fiber, polyvinyl chloride, etc. This product is plasticizer. It has a strong solubility for a variety of resins. Mainly used in PVC processing, can be given in the product of good flexibility. Because of its relatively low price and good processability, it is widely used in China, and it is equivalent to DOP. However, the volatility and water extraction is large, so the durability of the product is poor, and its use should be gradually limited. The product is a good increase in the plasticity of cellulose nitrate, gel ability. For nitrocellulose coating, there is a good softening effect. Stability, flex resistance, adhesion and water resistance are excellent. In addition, the product can also be used as polyvinyl acetate, alkyd resin, ethyl cellulose and chloroprene rubber plasticizer, can also be used in the manufacture of paints, adhesives, artificial leather, printing ink, safety glass, celluloid, dyes, pesticides, perfume solvents, fabric lubricants, etc. used as gas chromatography stationary liquid, solvent and plasticizer used as cellulose ester, salt and natural rubber, polystyrene plasticizer; Make polyvinyl chloride and its copolymer have cold resistance organic synthesis, ion selective electrode additives, solvents, pesticides, plasticizers, gas chromatography stationary liquid (maximum use temperature 100 ℃, solvent acetone, benzene, dichloromethane, ethanol), selective retention and separation of aromatic compounds, unsaturated compounds, terpene compounds and various oxygenates (alcohols, aldehydes, ketones, esters, etc.). |
production method | The esterification reaction was carried out at atmospheric pressure using phthalic anhydride and n-butanol as raw materials and sulfuric acid as a catalyst. After completion of the reaction, the reaction was neutralized with an alkali solution and washed with water, followed by dealcoholation and pressure filtration to obtain a finished product. There are two kinds of Processing Technology: batch method and continuous method. Raw material consumption quota: phthalic anhydride 540kg/t, butanol (95%)560kg/t. |
category | flammable liquid |
toxicity grade | poisoning |
Acute toxicity | oral-rat LD50: 7499 mg/kg; Oral-mouse LD50: 3484 mg/kg |
explosive hazard characteristics | mixture with air, heat, open flame can be broken |
flammability hazard characteristics | flammable in open flame, high temperature, strong oxidant; combustion emissions |
storage and transportation characteristics | The package is complete, light, light; The warehouse is ventilated, away from open flame, high temperature, separate from oxidant |
fire extinguishing agent | foam, carbon dioxide, dry powder, sand |
Occupational Standard | TLV-TWA 5 mg/m3; Tel 10 mg/m3 |
spontaneous combustion temperature | 756 ° F. |
toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
immediate life-and health-threatening concentration | 4,000 mg/m3 |