OEM 3-Hydroxytyramine hydrochloride
3-Hydroxytyramine hydrochloride
CAS: 62-31-7
Molecular Formula: C8H12ClNO2
OEM 3-Hydroxytyramine hydrochloride - Names and Identifiers
| Name | 3-Hydroxytyramine hydrochloride |
| Synonyms | Dopamine HCL dopaminechloride TIMTEC-BB SBB003668 Dopamine hydrochloride 3-Hydroxytyramine, HCl 3-Hydroxytyramine hydrochloride 3,4-DIHYDROXYPHENETHYLAMINE, HCL OEM 3-Hydroxytyramine hydrochloride 4-(2-aminoethyl)-pyrocatechohydrochloride 3,4-DIHYDROXYPHENETHYLAMINE HYDROCHLORIDE 3,4-Dihydroxyphenethylamine hydrochloride 2-benzenediol,4-(2-aminoethyl)-hydrochloride |
| CAS | 62-31-7 |
| EINECS | 200-527-8 |
| InChI | InChI=1/C8H11NO2.ClH/c9-4-3-6-1-2-7(10)8(11)5-6;/h1-2,5,10-11H,3-4,9H2;1H |
| InChIKey | CTENFNNZBMHDDG-UHFFFAOYSA-N |
OEM 3-Hydroxytyramine hydrochloride - Physico-chemical Properties
| Molecular Formula | C8H12ClNO2 |
| Molar Mass | 189.64 |
| Density | 1.4 g/cm3 |
| Melting Point | 248-250°C(lit.) |
| Boling Point | 337.7 °C at 760 mmHg |
| Flash Point | 11℃ |
| Water Solubility | soluble |
| Solubility | Soluble in water, soluble in methanol and hot 95% ethanol, soluble in sodium hydroxide solution, insoluble in ether, chloroform and benzene. |
| Appearance | White-like crystal |
| Color | light tan |
| Merck | 14,8462 |
| BRN | 3656720 |
| Storage Condition | Store below +30°C. |
| Stability | Stable. Incompatible with strong oxidizing agents. Combustible. |
| Sensitive | Air & Light Sensitive |
| MDL | MFCD00012898 |
| Physical and Chemical Properties | Melting Point: 241 - 243
|
| Use | Dopamine agonist, excites the heart, increases renal blood flow, for hemorrhagic, cardiac and Infective Shock |
OEM 3-Hydroxytyramine hydrochloride - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R22 - Harmful if swallowed R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. |
| UN IDs | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 2 |
| RTECS | UX1092000 |
| FLUKA BRAND F CODES | 8-10-23 |
| TSCA | Yes |
| HS Code | 29222900 |
| Hazard Note | Irritant |
| Toxicity | LD50 orally in Rabbit: 2859 mg/kg |
OEM 3-Hydroxytyramine hydrochloride - Standard
Authoritative Data Verified Data
This product is 4-(2-aminoethyl)-1, 2-benzenediol hydrochloride. Calculated as dry product, containing no less than 98.0% of C8H11N02 • HCl.
Last Update：2024-01-02 23:10:35
OEM 3-Hydroxytyramine hydrochloride - Trait
Authoritative Data Verified Data
- This product is white or off-white crystalline or crystalline powder; Odorless; Open air and light color gradient deep.
- This product is soluble in water, slightly soluble in anhydrous ethanol, and slightly soluble in chloroform or ether.
Last Update：2022-01-01 14:23:09
OEM 3-Hydroxytyramine hydrochloride - Differential diagnosis
Authoritative Data Verified Data
- take about 10mg of this product, add 1 ml of water to dissolve, add 1 drop of ferric chloride test solution, the solution is dark green; Drop 1% ammonia solution, it is turned into purple red.
- take this product and add 0.5% sulfuric acid solution to make a solution containing about 30ug per 1 ml, and measure it by UV-visible spectrophotometry (General 0401), there is an absorption maximum at a wavelength of 280mn.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 345).
- the aqueous solution of this product was chloride identification (1) of the reaction (General 0301).
Last Update：2022-01-01 14:23:10
OEM 3-Hydroxytyramine hydrochloride - Exam
Authoritative Data Verified Data
acidity
The pH value of the solution under the items of clarity and color shall be determined according to law (General rule 0631), and the pH value shall be 3.5~5.5.
clarity and color of solution
take 0.10g of this product and add 10ml of freshly boiled cold water to dissolve, the solution should be clear and colorless; If it is colored, it should be compared with the yellow No. 1 Standard Colorimetric solution (General rule 0901 first method), not deeper.
Related substances
take this product, add mobile phase to dissolve and dilute to make a solution containing about 0.3mg per 1ml as a test solution; Take 1ml for precision measurement and put it in a 100ml measuring flask, dilute to the scale with the mobile phase, shake, and serve as a control solution. Appropriate amounts of dopamine hydrochloride reference substance and 4-ethylphthalic acid were dissolved and diluted with mobile phase to prepare a mixed solution containing about 6% of each 1 ml, which was used as a system applicable solution. According to the test of high performance liquid chromatography (General 0512), silica gel bonded with eighteen alkyl silane was used as the filler; Sodium dodecyl sulfate-acetonitrile-glacial acetic acid -0. The mobile phase consisted of 1 mol/L disodium ethylenediamine tetraacetate (700:300:10:2). The detection wavelength was 280nm. The system applicable solution 20 u1 was injected into the liquid chromatograph, and the resolution of dopamine peak and 4-ethylcatechol peak should be greater than 3.0. 20 u1 of the test solution and the control solution were respectively injected into the human liquid chromatograph, and the chromatogram was recorded to 3 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 0.5 times (0.5%) of the area of the main peak of the control solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (1.0%).
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
ignition residue
not more than 0.1% (General rule 0841).
Heavy metals
take 1.0g of this product, add an appropriate amount of water to dissolve, and check according to law (General rule 0821 first law), containing heavy metals not to exceed 20 parts per million.
Last Update：2022-01-01 14:23:10
OEM 3-Hydroxytyramine hydrochloride - Content determination
Authoritative Data Verified Data
take about 0.15g of this product, weigh precisely, add 25ml of glacial acetic acid, boil to dissolve, cool to about 40°C, add 5ml of Mercury acetate test solution, and let cool, add 1 drop of crystal violet indicator solution and use perchloric acid titration solution (0.1 mol/L) titration to the solution is blue-green, and the result of the titration is corrected with a blank test. Each 1 ml perchloric acid titration solution (0.1 mol/L) corresponds to 18.96mg of C8H11NO2 • HCl.
Last Update：2022-01-01 14:23:11
OEM 3-Hydroxytyramine hydrochloride - Category
Authoritative Data Verified Data
dopamine receptor agonists.
Last Update：2022-01-01 14:23:11
OEM 3-Hydroxytyramine hydrochloride - Storage
Authoritative Data Verified Data
shading, nitrogen filling, sealed preservation.
Last Update：2022-01-01 14:23:11
OEM 3-Hydroxytyramine hydrochloride - Dopamine Hydrochloride Injection
Authoritative Data Verified Data
This product is a sterile aqueous solution of dopamine hydrochloride. Containing dopamine hydrochloride (C8H11N02 • HCl) shall be between 93.0% and 107.0% of the nominal amount.
trait
This product is a clear colorless liquid.
identification
This product was taken and the same results were shown in the tests of (1), (2) and (4) under the item of dopamine hydrochloride.
examination
- the pH value should be 3.0 to 4.5 (General 0631).
- precise measurement of related substances: take an appropriate amount of this product and dilute it with mobile phase to make a solution containing 0.3mg of dopamine hydrochloride in each lml as a test solution; Take lml for precise measurement and place it in a 100ml measuring flask, dilute to the scale with the mobile phase, shake, and serve as a control solution. According to the method of dopamine hydrochloride related substances. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 0.5 times (0.5%) of the area of the main peak of the control solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (1.0%).
- bacterial endotoxin this product, according to the law to check (General 1143), each 1 mg of dopamine hydrochloride in the amount of endotoxin should be less than 1.5EU.
- others should comply with the relevant provisions under injection (General 0102).
determination of content
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; 0.005mol/L sodium dodecyl sulfate-acetonitrile-glacial acetic acid -0. The mobile phase consisted of 1 mol/L disodium ethylenediamine tetraacetate (700:300:10:2). The detection wavelength was 280nm. The appropriate amount of dopamine hydrochloride reference substance and 4-ethylcatechol was taken, dissolved and diluted with mobile phase to prepare a mixed solution containing about 6ug in each lml, and 20u1 was injected into a human liquid chromatograph. The resolution of the dopamine peak and the 4-ethylcatechol peak should be greater than 3.0.
- determination precision: take an appropriate amount of this product and quantitatively dilute it with mobile phase to make a solution containing 30 μl of dopamine hydrochloride per 1 ml. Take 20 u1 for precision measurement and inject it into human liquid chromatograph to record the chromatogram. Another dopamine hydrochloride reference substance was accurately weighed and determined by the same method, and the peak area was calculated by external standard method.
category
Same as dopamine hydrochloride.
specification
2ml:20mg
storage
light shielding, closed storage.
Last Update：2022-01-01 14:23:12
OEM 3-Hydroxytyramine hydrochloride - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Introduction | the neurotransmitter dopamine is widely distributed in the mammalian central nervous system, brain tissue and body fluids, its trace determination is of great significance in neurophysiology, exercise physiology, pathology, clinical medicine and disease diagnosis. Dopamine (DA) is one of the most important catecholamines, which plays a key role in the central nervous system and renal system. Disorders such as heart disease, schizophrenia, and Parkinson's disease can result from an imbalance in dopamine production. Dopamine Hydrochloride water soluble, can enhance myocardial contractility, increase blood output, and a large number of used in myocardial infarction, trauma, endotoxin sepsis, cardiac surgery, renal failure, congestive heart failure caused by Shock syndrome. |
| Application | dopamine hydrochloride can be used for various types of Shock, hypotension. Including toxic Shock, cardiac Shock, hemorrhagic Shock, central Shock, especially for patients with renal insufficiency, decreased cardiac output, increased peripheral vascular resistance and has made up the blood volume. Also can treat cardiac insufficiency, acute renal insufficiency. |
| pharmacological effects | This product is a precursor for the synthesis of epinephrine in vivo, with beta (mainly beta 1 receptor) receptor agonist effect, it also has an alpha receptor agonistic effect and can also promote the release of norepinephrine. It can enhance myocardial contractility, increase cardiac output, and accelerate heart rate slightly (not as obvious as isoproterenol). It excites alpha receptors of blood vessels in tissues such as skin and muscle, and reduces blood flow supply; exciting visceral blood vessels (kidney, mesentery, heart) of dopamine receptors, then make the expansion, increase blood flow. The change of total peripheral resistance was not obvious, but it was beneficial to improve the blood supply of important organs by Shock. |
| effect | dopamine is a precursor of norepinephrine biosynthesis, one of the central transmitters, with the ability of stimulating β-receptor, action of a-receptors and dopamine receptors, exciting the heart beta-receptors can increase myocardial contractility, increase cardiac output. Stimulating dopamine receptors and α-receptors dilates the kidney, mesentery, coronary artery and cerebral vessels, and increases blood flow. It has mild contractile effect on peripheral blood vessels and increases arterial blood pressure. The prominent effect of this drug is to increase renal blood flow and glomerular filtration rate, thus promoting the increase of urine volume and urinary sodium excretion. Clinical for various types of Shock, especially for Shock with reduced cardiac contractility, renal insufficiency. |
| adverse reactions | the common ones are chest pain, Dyspnea, palpitations, arrhythmia (especially in large doses), rapid and potent heart beat, weakness and weakness of the whole body; Slow heartbeat, vomiting in Head Pain and Nausea were rare. Long-term use of large or small doses in patients with peripheral vascular disease, the reaction of hand foot pain or cold hands and feet; Peripheral vascular contraction for a long period of time, may lead to local necrosis or gangrene. |
| purpose | This product is a vasopressor and a Biochemical reagent. Dopamine receptor agonist, can stimulate the heart, increase renal blood flow, for hemorrhagic, cardiac and Infective Shock. Neurotransmitter |
| production method | is obtained by ring-opening piperonyl ethylamine. Piperonyl ethylamine and phenol were added to the reaction Pan, cooled, hydrochloric acid was slowly added, and the temperature was raised to 110 ° C. And refluxed for 12-44H. After the reaction reached the end point, it was slightly cooled, and water was added and stirred evenly. The patient was allowed to stand in layers, and phenol layer was removed. The aqueous layer was extracted with isopropyl acetate, and the extracted aqueous layer was evaporated to dryness under reduced pressure (8.0kPa). Then, a 1/2 amount of ethanol and hydrochloric acid were added and dissolved by heating. The product was obtained by cooling, crystallization, filtration, washing of the filter cake with ethanol, and drying. The yield was 74%. |
| category | toxic substances |
| toxicity grade | poisoning |
| Acute toxicity | oral-rat LD50 2859 mg/kg; Oral-mouse LD50: 4361 mg/kg |
| flammability hazard characteristics | flammable, combustion decomposition of toxic nitrogen oxides, chloride gas |
| storage and transportation characteristics | warehouse low temperature, ventilation, dry |
| extinguishing agent | water, carbon dioxide, dry powder, sand |
Last Update：2024-04-10 22:29:15
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CAS: 62-31-7
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