ONO-9302
Epristeride
CAS: 119169-78-7
Molecular Formula: C25H37NO3
ONO-9302 - Names and Identifiers
ONO-9302 - Physico-chemical Properties
| Molecular Formula | C25H37NO3 |
| Molar Mass | 399.57 |
| Density | 1.13±0.1 g/cm3(Predicted) |
| Melting Point | 242-249° |
| Boling Point | 596.0±50.0 °C(Predicted) |
| pKa | 4.8(at 25℃) |
| Storage Condition | 2-8℃ |
| Physical and Chemical Properties | White crystals are obtained from ethyl acetate with a melting point of 242~249 ℃. pK4.8. |
| Use | It is a treatment for benign prostatic hyperplasia. It is a strong inhibitor of type 2 sterol 5 α-reductase and has weak inhibitory power on type 1 enzyme. Testosterone reductase inhibitors. |
ONO-9302 - Upstream Downstream Industry
ONO-9302 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.503 ml | 12.514 ml | 25.027 ml |
| 5 mM | 0.501 ml | 2.503 ml | 5.005 ml |
| 10 mM | 0.25 ml | 1.251 ml | 2.503 ml |
| 5 mM | 0.05 ml | 0.25 ml | 0.501 ml |
Last Update：2024-01-02 23:10:35
ONO-9302 - Introduction
Biological activity
Epristeride is a new type of 5 α-reductase inhibitor.
Target
5α-reductase
Chemical properties
white crystal from ethyl acetate, melting point 242~249 ℃. pK4.8.
Production method
3-oxoandrost-4-ene-17 β-carboxylic acid methyl ester (Ⅰ) is treated with phosphorus tribromide in glacial acetic acid, converted into compound (Ⅱ), and then hydrolyzed into compound (Ⅲ). First react with oxalyl chloride, and then tert-butylamine is quenched to obtain compound (Ⅳ). (Ⅳ) After treatment with ethyl magnesium bromide, adding sec-butyl lithium, and using carbon dioxide for halogen metal exchange reaction, the crude product of eriandrostine is obtained. The crude product can be heated and refined in ethyl acetate.
Last Update：2024-04-10 22:29:15
ONO-9302 - Reference Information
| biological activity | Epristeride is a new type of 5 α-reductase inhibitor. |
| target | 5α-reductase |
| chemical properties | white crystal from ethyl acetate, melting point 242~249 ℃. pK4.8. |
| use | is a therapeutic drug for benign prostatic hyperplasia. It is a strong inhibitor of type 2 sterol 5 α-reductase and has weak inhibitory power on type 1 enzyme. Testosterone reductase inhibitor. |
| Production method | 3-oxoandrost-4-ene-17 β-carboxylic acid methyl ester (Ⅰ) is treated with phosphorus tribromide in glacial acetic acid, converted into compound (Ⅱ), and then hydrolyzed into compound (Ⅲ). First react with oxalyl chloride, and then tert-butylamine is quenched to obtain compound (Ⅳ). (Ⅳ) After treatment with ethyl magnesium bromide, adding sec-butyl lithium, and using carbon dioxide for halogen metal exchange reaction, the crude product of eriandrostine is obtained. The crude product can be heated and refined in ethyl acetate. |
Last Update：2024-04-09 19:05:05
Supplier List
Spot supply
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CAS: 119169-78-7
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CAS: 119169-78-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Finasteride Impurity 30 Visit Supplier Webpage Request for quotationCAS: 119169-78-7
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: Epristeride Visit Supplier Webpage Request for quotation
CAS: 119169-78-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 119169-78-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History
Raw Materials for ONO-9302