Olean-12-en-28-oicacid, 2,3,16,23-tetrahydroxy-, (2β,3β,4,16)-

Name	Polygalacic acid
Synonyms	Polygalacic Polygalacic acid Virgaureagenin G (4R)-2β,3β,16α,23-Tetrahydroxyolean-12-en-28-oic acid (2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid Olean-12-en-28-oicacid, 2,3,16,23-tetrahydroxy-, (2β,3β,4,16)- (2beta,3beta,16alpha)-2,3,16,23-tetrahydroxyolean-12-en-28-oic acid Polygalacic acid (2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid (2beta,3beta,5xi,16alpha,18alpha)-2,3,16,23-tetrahydroxyolean-12-en-28-oic acid Polygalacic acid or (2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid
CAS	22338-71-2
InChI	InChI=1/C30H48O6/c1-25(2)11-12-30(24(35)36)18(13-25)17-7-8-21-26(3)14-19(32)23(34)27(4,16-31)20(26)9-10-28(21,5)29(17,6)15-22(30)33/h7,18-23,31-34H,8-16H2,1-6H3,(H,35,36)/t18-,19-,20+,21+,22+,23-,26-,27-,28+,29+,30+/m0/s1

Molecular Formula	C30H48O6
Molar Mass	504.7
Density	1.23±0.1 g/cm3(Predicted)
Melting Point	300-305 °C (sublm)
Boling Point	638.1±55.0 °C(Predicted)
Specific Rotation(α)	+18 (EtOH)
Flash Point	353.69°C
Solubility	Soluble in DMSO, methanol and pyridine
Vapor Presure	0mmHg at 25°C
Appearance	White needle crystal powder
pKa	4.41±0.70(Predicted)
Storage Condition	2-8℃
Refractive Index	1.593
MDL	MFCD10566611

HS Code

29163990

Biological activity	Polygalacic acid is a triterpenoid tetrahydroxy acid isolated from the genus Polygala (Polygala paenea L.). Polygalacic acid (0-100μM; 24h) can significantly reduce the mRNA expression of MMP-3, MMP-9, MMP-13 and COX-2. The expression of these factors can be significantly increased induced by IL-1β in a dose-dependent manner.
Cell Line:	Chondrocyte cells Chondrocyte cells
Concentration:	50 μM; 100 μM 50 μM; 100 μM
Incubation Time:	24 hours 6 hours
Result:	Suppressed IL-1β-induced COX-2, MMP3, MMP9, and MMP13 mRNA expression. Inhibited the IL-1β-induced activation of the MAPK pathway in chondrocytes.
use	tranquilizing nerves, eliminating phlegm, reducing swelling, etc. clinically, it is mostly used to treat bronchitis, induced labor, induced labor, etc.

Last Update：2024-04-09 15:16:49

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CAS: 22338-71-2
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