Oxolinic Acid EP Impurity B
OXOLINIC ACID IMPURITY B
CAS: 16172-03-5
Molecular Formula: C15H15NO5
Oxolinic Acid EP Impurity B - Names and Identifiers
Oxolinic Acid EP Impurity B - Physico-chemical Properties
| Molecular Formula | C15H15NO5 |
| Molar Mass | 289.28 |
| Appearance | neat |
Oxolinic Acid EP Impurity B - Reference Information
| quinolinone fungicides | oxoquinolinic acid, also known as oxo-oxoquinolinic acid, orinic acid, belongs to the second generation of quinolinone fungicides, white yellow-white columnar crystal or crystalline powder at room temperature, odorless and tasteless, and has strong antibacterial effect on gram-negative bacteria and some positive bacteria, it has no cross-resistance with antibiotics, but it has no antibacterial effect on fungi and Mycobacterium tuberculosis. It has the advantages of low dosage and good antibacterial effect. It is mainly used to treat bacterial diseases of fish and shrimp. Aquaculture farmers think it is one of the ideal drugs for the treatment of aquatic animal diseases. It has strong antibacterial activity against fish pathogens such as Vibrio anguillarum and Aeromonas hydrophila. Therefore, eels and other aquatic animals in Japan and Taiwan Province are widely used. PH has a slight impact on them in mariculture, and the dosage should be increased in alkaline environment. Oxolinic acid has little toxicity, acute, toxicity test for carp oral median lethal dose (that is, under the influence of a certain concentration of the drug can make 50% individual death time) is more than 4000 mg/kg. The use of this drug must be stopped 25 days ago, otherwise the residual amount exceeds the standard. The Japanese market prohibits imports. Taiwan has updated the allowable amount of Oxolinic acid in the muscle, fat, liver and kidney of fish, shrimp, eggs, cattle, pigs, and chickens. There is an evolutionary process in the use of eel drugs in various countries. In September 1991, Japan's International Bureau of Veterinary Epidemic Affairs held a special meeting to discuss the use standards of aquatic medicine for Japanese eels and the issue of chemotherapy in aquaculture, involving therapies, drug toxicity, drug resistance, residues and other issues. The general trend is: fish diseases increase and therapeutic drugs increase, the increase of residual drugs in the environment is a new and important problem facing the breeding interface. Therefore, Japan revised the use standard of aquatic medicines three times from 1991 to 1992, and promulgated the "standard" for the use of eel aquatic medicines. The names and methods of use of drugs that can be used and those that cannot be used. Although oxolinic acid is listed as a drug that can be used within the scope of the use standard, and the oxolinic acid has a withdrawal period of 25 days, less than 20 mg/kg of fish/day, and the oral and pharmaceutical solvent is maintained for 6 hours, the China Food, Native Animal Import and Export Chamber of Commerce In order to make my country's export eel breeding scientific, its products meet the food hygiene requirements of the importing country, enhance the confidence of importers in purchasing Chinese eels, and stabilize the export market, on April 28, 1989, it issued a document promulgating the health management and medication management (interim) measures for China's export eel. It is clearly stipulated that oxolinic acid and malachite green methyl blue are prohibited drugs. |
Last Update：2024-04-09 20:52:54
