PYR-HIS-PRO

Name	TRH
Synonyms	TRH PYR-HP TRH-OH PYR-HIS-PRO GLP-HIS-PRO PGLU-HIS-PRO PYR-HIS-PRO-OH TRH (FREE ACID)
CAS	24769-58-2

Molecular Formula	C16H21N5O5
Molar Mass	363.37
Density	1.461±0.06 g/cm3(Predicted)
Boling Point	942.1±65.0 °C(Predicted)
pKa	3.29±0.20(Predicted)
Storage Condition	−20°C
In vitro study	TRH degradation products have been shown to be associated with a number of endocrine- and central nervous system-related biological functions. TRH (pGlu-His-Pro-NH2) can be enzymatically degraded in plasma and brain tissue to yield TRH-OH. TRH and hGHRH stimulate the release of [ 3 H]GH into the culture medium to 435 and 464%, respectively, when compared to the control, but TRH-OH has no effect. TRH-OH, produced after cleavage of the C-terminal amide group by a specific proline endopeptidase, is one of the most stable derivatives of TRH and is found at high levels in numerous brain regions. TRH-OH inhibits Na + channel activity in mammalian septal neurons. In about 60% of the cells tested, TRH-OH at concentrations between 0.01 and 2.5 μM produces a dose-dependent reversible attenuation of Na+ currents. With 2 μM TRH-OH, peak Na + current amplitude is reduced by 20-50%.

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