PYRIDINE-2-CARBONYL CHLORIDE HYDROCHLORIDE

PYRIDINE-2-CARBONYL CHLORIDE HYDROCHLORIDE - Names and Identifiers

Name	Picolinoyl chloride hydrochloride
Synonyms	Nsc254051 NSC 254051 Pyridine-2-Carbonyl Pyridine-2-carbonylchlorideHCl 2-Picolyl chloride hydrochloride Picolinoyl chloride hydrochloride PICOLINOYL CHLORIDE HYDROCHLORIDE Pyridine-2-carbonylchloridehydrochloride 2-Pyridinecarbonyl chloride, hydrochloride PYRIDINE-2-CARBONYL CHLORIDE HYDROCHLORIDE forMyl(pyridin-2-yl)chloranuide hydrochloride Picolinoyl chloride hydrochloride, 2-(Chlorocarbonyl)pyridine hydrochloride
CAS	39901-94-5
InChI	InChI=1/C6H4ClNO.ClH/c7-6(9)5-3-1-2-4-8-5;/h1-4H;1H

PYRIDINE-2-CARBONYL CHLORIDE HYDROCHLORIDE - Physico-chemical Properties

Molecular Formula	C6H5Cl2NO
Molar Mass	178.02
Melting Point	123°C
Boling Point	204.1°C at 760 mmHg
Flash Point	77.3°C
Vapor Presure	0.268mmHg at 25°C
Appearance	Brown solid
Color	White to Gray to Red
Storage Condition	Inert atmosphere,2-8°C
MDL	MFCD00060193

PYRIDINE-2-CARBONYL CHLORIDE HYDROCHLORIDE - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	R34 - Causes burns R36 - Irritating to the eyes R22 - Harmful if swallowed
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
UN IDs	1759
Hazard Class	8
Packing Group	II

PYRIDINE-2-CARBONYL CHLORIDE HYDROCHLORIDE - Introduction

Picolinoyl chloride hydrochloride, chemical formula C7H7Cl2NO, is an organic compound. It is a white or off-white solid with a pungent odor. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: Picolinoyl chloride hydrochloride appear as crystals or crystalline powder, soluble in alcohol and some organic solvents, insoluble in water.
-Melting point: about 60°C to 65°C.
-Density: about 1.37g/cm³.
-toxicity: belong to organic chlorine compounds, has a certain toxicity.

Use:
Picolinoyl chloride hydrochloride has certain uses in the field of organic synthesis, commonly used in the following aspects:
-as an acylating reagent: it can be used in the acylation reaction to react with ketones, aldehydes, amines, etc. to generate the corresponding acylated products.
-As a reagent in the protecting group reaction: In organic synthesis, it can be used as a protecting group reagent for chlorination reaction to protect amine or alcohol groups, thereby preventing non-selective reactions during the synthesis process.

Preparation Method:
The preparation of Picolinoyl chloride hydrochloride can be carried out by the following steps:
1. Pyridine-2-carboxylic acid is dissolved in anhydrous hydrogen chloride, and nitrous acid is added to react to generate nitroso compound.
2. The nitroso compound obtained in the first step is dissolved in an alkylene chloride and reacted to generate a Picolinoyl chloride hydrochloride.
3. The prepared product is purified by freeze crystallization or vacuum drying to obtain the final product.

Safety Information:
- Picolinoyl chloride hydrochloride belongs to organic chlorine compounds, has certain toxicity. Safety precautions should be taken during use to avoid contact with skin and inhalation of gas.
-Use should comply with the laboratory's chemical operating specifications to avoid the release of toxic gases and other dangerous situations.
-Storage should be sealed and kept away from fire and heat sources to prevent contact with oxidants.

Last Update：2024-04-10 22:29:15