Pharmaceutical Chemical Anticancer Drug Azd-9291 for for Lung Cancer 1421373-65-0
AZD9291
CAS: 1421373-65-0
Molecular Formula: C28H33N7O2
Pharmaceutical Chemical Anticancer Drug Azd-9291 for for Lung Cancer 1421373-65-0 - Names and Identifiers
Pharmaceutical Chemical Anticancer Drug Azd-9291 for for Lung Cancer 1421373-65-0 - Physico-chemical Properties
| Molecular Formula | C28H33N7O2 |
| Molar Mass | 499.61 |
| Density | 1.19±0.1 g/cm3(Predicted) |
| Melting Point | >188oC (dec.) |
| Solubility | DMSO (Slightly, Heated), Methanol (Slightly, Heated) |
| Appearance | Form Solid, color Pale Yellow to Beige |
| Color | Pale Yellow to Beige |
| pKa | 12.68±0.70(Predicted) |
| Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| In vitro study | AZD9291 inhibited proliferation more efficiently in mutant EGFR cell lines than wild-type in vitro. compared with wild-type in vitro, AZD9291 was more effective in inhibiting proliferation in mutant EGFR cell lines. |
| In vivo study | AZD9291(5 mg/kg p.o.) causes significant tumor regression in whole EGFRm (PC9) and EGFRm / T790M(H1975) tumor model tumors, accompanied by in vivo phosphorylation of EGFR and downstream key signaling pathways, as a significant inhibition of AKT and ERK. AZD9291(5 mg/kg p.o.) causes significant tumor regression in whole EGFRm (PC9) and EGFRm / T790M(H1975) tumor model tumors, accompanied by in vivo phosphorylation of EGFR and downstream key signaling pathways, as a significant inhibition of AKT and ERK. |
Pharmaceutical Chemical Anticancer Drug Azd-9291 for for Lung Cancer 1421373-65-0 - Risk and Safety
| HS Code | 29339900 |
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Product Name: AZD9291 Request for quotationCAS: 1421373-65-0
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Product Name: AZD9291 Request for quotation
CAS: 1421373-65-0
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 1421373-65-0
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Spot supply
Product Name: Osimertinib Visit Supplier Webpage Request for quotationCAS: 1421373-65-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
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