Pharmatose 150M
Lactose Monohydrate
CAS: 5989-81-1
Molecular Formula: C12H24O12
Pharmatose 150M - Names and Identifiers
| Name | Lactose Monohydrate |
| Synonyms | MILK SUGAR Pharmatose 150M Lactose Monohydrate ALPHA-LACTOSE MONOHY MILK SUGAR MONOHYDRATE alpha-Lactose monohydrate LACTOSE MONOHYDRATE, a-(RG) 4-O-beta-D-talopyranosyl-beta-L-talopyranose 4-O-alpha-L-gulopyranosyl-beta-L-talopyranose 4-O-alpha-L-allopyranosyl-beta-L-talopyranose 4-O-beta-D-mannopyranosyl-beta-L-talopyranose 4-O-beta-D-galactopyranosyl-beta-D-glucopyranose hydrate 4-O-beta-D-Galactopyranosyl-alpha-D-glucopyranose monohydrate alpha-D-Glucopyranose, 4-O-beta-D-galactopyranosyl-, monohydrate |
| CAS | 5989-81-1 |
| EINECS | 611-913-4 |
| InChI | InChI: 1S/C12H22O11.H2O/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17;/h3-20H,1-2H2;1H2 |
| InChIKey | WSVLPVUVIUVCRA-KPKNDVKVSA-N |
Pharmatose 150M - Physico-chemical Properties
| Molecular Formula | C12H24O12 |
| Molar Mass | 360.31 |
| Density | 1,53 g/cm3 |
| Melting Point | 219 °C |
| Boling Point | 412.35°C (rough estimate) |
| Specific Rotation(α) | [α]D20+52.2～+52.8° |
| Flash Point | 357.752°C |
| Water Solubility | Soluble in water. |
| Solubility | Soluble in water, slightly soluble in alcohol, chloroform or ether insoluble. |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White crystal |
| Color | White to Off-White |
| PH | pH (50g/l, 25℃) : 4.0～6.0 |
| Storage Condition | Inert atmosphere,Room Temperature |
| Stability | Hygroscopic |
| Refractive Index | 1.6480 (estimate) |
| MDL | MFCD00150747 |
| Use | Used as analytical reagents, chromatographic analysis reagents, but also for the preparation of biological culture medium |
Pharmatose 150M - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R40 - Limited evidence of a carcinogenic effect R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| RTECS | OD9625000 |
| TSCA | Yes |
| HS Code | 17021100 |
Pharmatose 150M - Reference
| Reference Show more | 1. Liu Wei, Liu Wen, Song Xinli, etc. Preparation and quality evaluation of breviscapine gastric adhesive tablets [J]. China Pharmacy, 2020(14). 2. Dong Yining, Chen Wei, Deng Wenjun, etc. Composition analysis of food-grade galactooligosaccharides and estimation of effective component content based on fingerprint [J]. Food and machinery, 2018, 25 (7):54-58. 3. Qian Weidong, Fu Yunfang, Hu Na. Study on fermentation conditions of lactase production by Klyveromyces lactis yeast [J]. Chinese agricultural bulletin, 2012. 4. Zhang Xifeng, Liu Xiaoyan, Ma Yinshan, etc. Saccharification extraction and inhibition of advanced glycation end products of polyphenols from Lycium barbarum L. [J]. Fine Chemicals, 2018, 035(003):395-401. 5. Chen Yunyao, Luo Yang, Yan Shen et al. Determination of monosaccharide components in Dendrobium by HPAEC-PAD method and principal component cluster analysis [J]. Chinese Journal of Experimental prescriptions 2018(15). 6. Tang Xiaomeng, Huang Jinqian, Wang Wuqing, Gu Yongwei, Liu Jiyong. Preparation and in vitro release of colon-targeted capsule of Baizhu Huanglian pellets [J]. Journal of Pharmaceutical Practice, 2021,39(01):29-34. 7. Zhou Shuang. Effects of intestinal lactic acid bacteria from infants on intestinal immune function and Flora in mice [D]. Hebei University of Engineering, 2020. 8. Zang, Zhihua, et al. "Effect of whey protein isolate on the stability and antioxidant capacity of blueberry anthocyanins: A mechanistic and in vitro simulation study." Food Chemistry 336 (2021): 127700.https://doi.org/10.1016/j.foodchem.2020.127700 9. [IF=7.514] Wei-Yu Mu et al."Determination of melamine and melamine-Cu(II) complexes in milk using a DNA-Ag hydrocolloid as the sensor."Food Chem. 2020 May;311:125889 10. [IF=7.514] Yi-Hao Liu et al."Efficient sequential synthesis of lacto-N-triose II and lacto-N-neotetraose by a novel β-N-acetylhexosaminidase from Tyzzerella nexilis."Food Chem. 2020 Dec;332:127438 11. [IF=7.46] Qian Su et al."Dual-emissive fluorescence and phosphorescence detection of cholesterol and glucose based on carbon dots-cyanuric acid complex quenched by MnO2 nanosheets."Sensor Actuat B- Chem. 2021 May;335:129715 12. [IF=6.057] Xi Lin et al."A dual-mode reactive matrix for sensitive and quantitative analysis of carbohydrates by MALDI-TOF MS."Talanta. 2021 Dec;235:122792 13. [IF=5.396] Shufen Wu et al."The noncovalent conjugations of human serum albumin (HSA) with MS/AK and the effect on anti-oxidant capacity as well as anti-glycation activity of Monascus yellow pigments."Food Funct. 2021 Apr;12(8):3692-3704 14. [IF=4.616] Ling Li et al."Point-of-care testing of melamine via gas pressure readout using polythymine-coated Au@Pt nanoparticles through specific triple hydrogen-bonding recognition."Analyst. 2021 Sep;146(19):5898-5903 15. [IF=4.142] Zhang Hao et al."A portable personal glucose meter method for enzyme activity detection and inhibitory activity evaluation based on alkaline phosphatase-mediated reaction."Anal Bioanal Chem. 2021 Apr;413(9):2457-2466 16. [IF=3.757] Yihao Liu et al."Biochemical characterization of a β-N-acetylhexosaminidase from Catenibacterium mitsuokai suitable for the synthesis of lacto-N-triose II."Process Biochem. 2021 Mar;102:360 17. [IF=3.352] Yuting Wang et al."Effects of packaging methods on the quality of heavy metals-free preserved duck eggs during storage."Poultry Sci. 2021 May;100:101051 18. [IF=4.641] Lihong Wu et al.NiFe2O4/CNTs fabricated by atomic layer deposition as highly stable peroxidase mimics for sensitive colorimetric detection of hydrogen peroxide and glucose.Mater Res Bull. 2022 Mar;147:111637 19. [IF=4.142] Zhang Wei et al."Ratiometric fluorescence and colorimetric dual-mode sensing platform based on carbon dots for detecting copper(II) ions and D-penicillamine."Anal Bioanal Chem. 2022 Feb;414(4):1651-1662 20. [IF=4.142] Zhang Wei et al."Ratiometric fluorescence and colorimetric dual-mode sensing platform based on carbon dots for detecting copper(II) ions and D-penicillamine."Anal Bioanal Chem. 2022 Feb;414(4):1651-1662 |
Pharmatose 150M - Standard
Authoritative Data Verified Data
This product is 4-Oi3-I> galactopyranosyl-I> glucose monohydrate. Calculated as anhydrous, containing C12 H2Z O, should be 98. 0% ~ 102.
Last Update：2024-01-02 23:10:35
Pharmatose 150M - Trait
Authoritative Data Verified Data
- This product is white crystalline particles or powder; Odorless, slightly sweet taste.
- This product is soluble in water and insoluble in ethanol, three gas methane or ether.
specific rotation
take this product, after drying at 80°C for 2 hours, precision weighing, adding water to dissolve and quantitatively dilute to make about 0 of this product per lm l. l g and ammonia test solution 0.0621 of the solution was measured according to the law (General rule 52.0), and the specific rotation was 10 52.6 ° to °.
Last Update：2022-01-01 11:23:28
Pharmatose 150M - Introduction
Lactose monohydrate is a natural disaccharide compound extracted from milk. It is composed of dextrose and galactose. It tastes slightly sweet,
Last Update：2022-10-16 17:26:52
Pharmatose 150M - Differential diagnosis
Authoritative Data Verified Data
- take 0.2g of this product, add 5 m l of sodium hydroxide test solution, slightly warm, the solution is yellow at the beginning, and then turns to Brown Red. Add a few drops of copper sulfate test solution to precipitate red precipitate of cuprous oxide.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 256) (General 0402).
Last Update：2022-01-01 11:23:29
Pharmatose 150M - Exam
Authoritative Data Verified Data
acidity
take this product l .O g, add water 20ml to dissolve, according to the law to determine (General 0631), p H value should be 4 .0~7.0.
clarity and color of solution
take this product 1. 0g, after adding 10ml of boiling water to dissolve, check according to law (General rule 0901 and General Rule 0 9 0 2 ) , the solution should be clear and colorless; If color development occurs, comparison with yellow No. 2 Standard Colorimetric solution (General rule 0901 first method), not deeper.
Related substances
take an appropriate amount of this product, add water to dissolve and dilute to make a solution containing lOOmg per lm l as a test solution; Take lm l with precision and put it in a 100ml measuring flask, water was added to dilute to the scale, shake, as a control solution. Test according to the method under the content determination item, record the chromatogram to 2 times the retention time of the main component peak. In the chromatogram of the test solution, except for the solvent peak, such as the impurity peak, the sum of the peak area of each impurity shall not be greater than 0. 5 times (0. 5%) of the peak area of the control solution.
absorbance of impurities
take this product, precision weighing, heated water dissolution and quantitative dilution into each lm l containing lOOmg solution, UV-visible spectrophotometry (General Rule 0 4 0 1), at the wavelength of 400nm absorbance measurement, not over 0.04. Then accurately absorb the above solution lm l, put it in a 10ml measuring flask, add water to dilute to the scale, according to UV-visible spectrophotometry (General rule 0401), the absorbance is measured in the wavelength range of 210 ~ 220nm. 2 5; Measuring absorbance in the wavelength range of 270 ~ 300mn, no #0.0 7.
Protein
Take 5. 0g of this product, dissolve 25ml of heated water, cool down, add 0.5ml of mercury nitrate test solution, and do not form flocculent precipitate within 5 minutes.
loss on drying
take this product, put the silica gel dryer in 80°C under reduced pressure drying to constant weight, weight loss shall not exceed 1.0% (General rule 0831).
moisture
take this product, with methanol-Formamide (2 : 1) as solvent, according to the determination method of moisture (General Principles 0832 first method 1), the moisture content should be 4. 5.5%.
ignition residue
The l .O g of this product shall be taken for inspection according to law (General rule 0841), and the remaining residue shall not exceed.
Heavy metals
take this product 3. 0g, after dissolving in 20ml of warm water, add 2M l of acetate buffer (ph3.5) and an appropriate amount of water to make 25ml, and check according to law (General Principles 0821, Law 1), heavy metals should not exceed 5 parts per million.
arsenic salt
take the residue under the ignition residue item, add 23ml of water to dissolve, add 5ml of hydrochloric acid, and check according to law (General rule 0822, Law 1), shall comply with the regulations ().
microbial limit
This product shall be taken and inspected according to law (General Principles 1105 and 1106). The total number of aerobic bacteria per l g of test product shall not exceed lOOcfu, the total number of molds and yeasts shall not exceed lOOcfu, E. Coli should not be detected.
Last Update：2022-01-01 11:23:30
Pharmatose 150M - Content determination
Authoritative Data Verified Data
measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using amino-bonded silica gel as filler; Acetonitrile-water (70 : 30) as mobile phase; Differential refractive index detector; Column temperature of 45°C, the detector temperature was 40°C. Take appropriate amount of lactose reference and sucrose reference respectively, weigh precisely, add water to dissolve and dilute to make solution containing lmg per LML, take lOpl, inject human liquid chromatograph, the separation degree between the lactose peak and the sucrose peak shall meet the requirements, and the number of lactose peaks in the theoretical plate shall not be less than 5000.
- The determination method is to take an appropriate amount of this product, accurately weigh it, add water to dissolve and quantitatively dilute it to make a solution containing about lm g lactose per lm l, and take 10 ^ 1 for precise measurement, note human liquid chromatograph, record chromatogram; Take appropriate amount of lactose reference substance, determine with the same method, and calculate with peak area according to external standard method.
Last Update：2022-01-01 11:23:30
Pharmatose 150M - Category
Authoritative Data Verified Data
pharmaceutical excipients, fillers and flavoring agents.
Last Update：2022-01-01 11:23:31
Pharmatose 150M - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 11:23:31
Pharmatose 150M - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Overview | sucrose, the main component of sugar, it is formed by condensation and dehydration of a hemiacetal hydroxyl group of one molecule of glucose and a hemiacetal hydroxyl group of one molecule of fructose. Its content in sugar cane, sugar beet and maple juice is particularly rich. Sucrose has a sweet taste and is an important food and sweet flavoring. |
| preparation method | the raw materials of sucrose are mainly sugar cane (sugar cane spp.) and sugar beet (Beta vulgaris). The sugar cane or sugar beet is crushed with a machine, the sugar juice is collected, filtered and treated with lime to remove impurities, and then bleached with sulfur dioxide; The treated sugar juice is boiled and the impurities in the bottom are removed, the foam floating onto the surface was scraped off and then quenched until the syrup crystallized into sucrose. |
| purpose | used as analytical reagent, chromatographic analysis reagent, also used in the preparation of biological media isolation of nitrilactose in GLC properties: a disaccharide isolated from mammalian milk. Milk containing about 4%-5%, human milk containing about 6.7%. Equal molecules of D-glucose and D-galactose are obtained by acidic hydrolysis. It is a reducing sugar, which can reduce the Ferrin solution. Α-lactose is obtained by crystallization in aqueous solution at normal temperature, and β-lactose is obtained by crystallization above 93 ℃. Alpha-lactose is the common form of lactose. There is a weak sweet taste, usually with a molecule of crystal water. Monoclinic crystal. Loss of crystal water at 120 ℃, rapid heating, the aqueous solution of change rotation phenomenon,[a]20D-92.6 ° → +83.5 °(10 min) → +69 °(50 min) +52.3 °(22 hours). Beta-lactose is slightly softer than alpha-lactose. White crystals. Melting point 252 °c. The aqueous solution also has the phenomenon of change rotation. [Α] 25D +34 °(3 min) → +39 °(6 min) → +46 °(1 hr) → 52.3 °(22 hr). After absorbing water at room temperature, β-lactose can be converted into α-lactose, which is changed into β-lactose when heated to above 93 °c. Xylenes and xylene isomers are components of the liquid-solid phase. chromatographic adsorbent. Bacterial culture medium. |
Last Update：2024-04-09 21:11:58
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