Phenethylboronic acid
2-Phenylethyl-1-boronic acid
CAS: 34420-17-2
Molecular Formula: C8H11BO2
Phenethylboronic acid - Names and Identifiers
Phenethylboronic acid - Physico-chemical Properties
| Molecular Formula | C8H11BO2 |
| Molar Mass | 149.98 |
| Density | 1.077±0.06 g/cm3(Predicted) |
| Melting Point | 76-81 °C (lit.) |
| Boling Point | 310.4±35.0 °C(Predicted) |
| Flash Point | 144.9°C |
| Vapor Presure | 0.000179mmHg at 25°C |
| pKa | 10.12±0.43(Predicted) |
| Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
| Refractive Index | 1.587 |
| MDL | MFCD01631226 |
| Use | Reactant involved in: Suzuki-Miyaura cross-coupling reactions Reactions with α-diazocarbonyl compounds C- H functionalization of quinones Cross-coupling with aromatic amines Arylation and alkylation of diphenylisoxazole Reactant used in studies of |
Phenethylboronic acid - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
Phenethylboronic acid - Introduction
2-Phenylethyl-1-boronic acid is an organic boron compound whose chemical formula is C8H11BO2. The following is a description of the nature, use, preparation and safety information of 2-Phenylethyl-1-boronic acid:
Nature:
-Appearance: 2-Phenylethyl-1-boronic acid is a solid, white crystalline powder.
-Solubility: It can be dissolved in water and common organic solvents (such as alcohols and ethers).
-Stability: It is relatively stable at room temperature, but may degrade under high temperature, light and humidity conditions.
Use:
-As a reducing agent: 2-Phenylethyl-1-boronic acid can be used as a reducing agent in organic synthesis to introduce phenylethyl functional groups into halogenated aromatic hydrocarbons or aldehydes.
-Adhesive agent: It can form a complex with metal or semi-metal, which is used to catalyze asymmetric synthesis reactions or as a catalyst in organic synthesis.
-Drug intermediate: 2-Phenylethyl-1-boronic acid can also be used as a synthetic drug intermediate for the preparation of various drugs.
Preparation Method:
2-Phenylethyl-1-boronic acid can be prepared by the reaction of phenethyl magnesium bromide and boric acid. Phenethylmagnesium bromide is first reacted with boric acid to give the magnesium salt of 2-Phenylethyl-1-boronic acid. The magnesium salt is then converted to 2-Phenylethyl-1-boronic acid by acidification or acid addition.
Safety Information:
2-Phenylethyl-1-boronic acid is a relatively safe compound in general. However, as with other chemicals, the following should be noted when used:
-Avoid contact with skin, eyes or inhalation of dust.
-Wear appropriate personal protective equipment such as gloves, safety glasses and protective face shields during handling and handling.
-Avoid high temperature, fire and humidity during storage.
-Waste disposal shall comply with local codes and regulations.
Please note that the above information is for reference only, and specific experimental operations and applications need to refer to relevant literature and safety guidelines.
Nature:
-Appearance: 2-Phenylethyl-1-boronic acid is a solid, white crystalline powder.
-Solubility: It can be dissolved in water and common organic solvents (such as alcohols and ethers).
-Stability: It is relatively stable at room temperature, but may degrade under high temperature, light and humidity conditions.
Use:
-As a reducing agent: 2-Phenylethyl-1-boronic acid can be used as a reducing agent in organic synthesis to introduce phenylethyl functional groups into halogenated aromatic hydrocarbons or aldehydes.
-Adhesive agent: It can form a complex with metal or semi-metal, which is used to catalyze asymmetric synthesis reactions or as a catalyst in organic synthesis.
-Drug intermediate: 2-Phenylethyl-1-boronic acid can also be used as a synthetic drug intermediate for the preparation of various drugs.
Preparation Method:
2-Phenylethyl-1-boronic acid can be prepared by the reaction of phenethyl magnesium bromide and boric acid. Phenethylmagnesium bromide is first reacted with boric acid to give the magnesium salt of 2-Phenylethyl-1-boronic acid. The magnesium salt is then converted to 2-Phenylethyl-1-boronic acid by acidification or acid addition.
Safety Information:
2-Phenylethyl-1-boronic acid is a relatively safe compound in general. However, as with other chemicals, the following should be noted when used:
-Avoid contact with skin, eyes or inhalation of dust.
-Wear appropriate personal protective equipment such as gloves, safety glasses and protective face shields during handling and handling.
-Avoid high temperature, fire and humidity during storage.
-Waste disposal shall comply with local codes and regulations.
Please note that the above information is for reference only, and specific experimental operations and applications need to refer to relevant literature and safety guidelines.
Last Update：2024-04-09 20:45:29
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