Molecular Formula | C15H16ClO4P |
Molar Mass | 326.71 |
Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
MDL | MFCD16652586 |
Hazard Symbols | Xn - Harmful |
Risk Codes | 22 - Harmful if swallowed |
WGK Germany | 3 |
Overview | diphenylchloromethyl phosphate is a pharmaceutical intermediate, it has been reported in the literature that diphenylchloromethyl phosphate is useful in the preparation of a water-soluble form of alcohol-and phenol-containing drugs such as Camptothecin and propofol. |
Application | diphenylchloromethyl phosphate is an organic phosphide, which is mainly used as an intermediate in organic synthesis and a pharmaceutical intermediate, can be used in laboratory research and development process and chemical and pharmaceutical synthesis process. |
synthesis method | in 20 minutes, several times to the refluxing of chloroiodomethane (25g,97%, to a solution of 0.14mol) in toluene (HPLC-grade, 30ml) was added dibenzyl phosphate silver salt (7.0g,0.018mol). Reflux was continued for 1 hour. After the reaction mixture was cooled to room temperature, it was filtered and the solvent was distilled off under reduced pressure. The oily residue was purified by flash column chromatography on silica gel (7: 3 hexane/ethyl acetate) to give 3.63g(62% yield) of the title compound as a yellow oil. |