Phthalazinone pyrazole Exclusive
Phthalazinone pyrazole
CAS: 880487-62-7
Molecular Formula: C18H15N5O
Phthalazinone pyrazole Exclusive - Names and Identifiers
Phthalazinone pyrazole Exclusive - Physico-chemical Properties
| Molecular Formula | C18H15N5O |
| Molar Mass | 317.34 |
| Solubility | ≤0.15mg/ml in DMSO;0.25mg/ml in dimethyl formamide |
| Storage Condition | -20℃ |
| Use | Phthalazinone pyrazole is potent, selective, and orally bioavailable inhibitor of Aurora-A kinase [1]. The Aurora protein kinase family consists of Aurora-A, -B and –C. The Aurora kinases are important group of enzymes involved in controlling several aspects of cell division in mammalian cells. Dysfunction of these kinases has been associated with a failure to maintain a stable chromosome content, a state that can contribute to tumourigenesis. Aurora-A is overexpressed in a variety of tumor types and displays oncogenic activity . |
Phthalazinone pyrazole Exclusive - Reference
| Reference Show more | [1] Prime M E, Courtney S M, Brookfield F A, et al. Phthalazinone pyrazoles as potent, selective, and orally bioavailable inhibitors of Aurora-A kinase[J]. Journal of medicinal chemistry, 2010, 54(1): 312-319.[2] Vader G, Lens S M A. The Aurora kinase family in cell division and cancer[J]. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 2008, 1786(1): 60-72. |
Phthalazinone pyrazole Exclusive - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.151 ml | 15.756 ml | 31.512 ml |
| 5 mM | 0.63 ml | 3.151 ml | 6.302 ml |
| 10 mM | 0.315 ml | 1.576 ml | 3.151 ml |
| 5 mM | 0.063 ml | 0.315 ml | 0.63 ml |
Last Update：2024-01-02 23:10:35
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Product Name: Phthalazinone pyrazole Visit Supplier Webpage Request for quotationCAS: 880487-62-7
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Mobile: 18021002903
QQ: 3008007409
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