Podophyllotoxin 9-Desoxy Impurity
Deoxypodophyllotoxin
CAS: 19186-35-7
Molecular Formula: C22H22O7
Podophyllotoxin 9-Desoxy Impurity - Names and Identifiers
Podophyllotoxin 9-Desoxy Impurity - Physico-chemical Properties
| Molecular Formula | C22H22O7 |
| Molar Mass | 398.41 |
| Density | 1.304±0.06 g/cm3(Predicted) |
| Melting Point | 168 °C |
| Boling Point | 564.5±50.0 °C(Predicted) |
| Specific Rotation(α) | -119 (CHCl3) |
| Solubility | Soluble in methanol, ether |
| Storage Condition | 2-8℃ |
| Physical and Chemical Properties | Colorless prismatic crystal (anhydrous ethanol), soluble in organic solvents such as methanol, ethanol, DMSO, etc., is derived from Taoerqi Sinopodophyllum hexandrum (Royle) Ying; The rhizome of octagonal lotus Dysosma versipellis (Hance) M. Cheng ex Ying. |
| In vitro study | Deoxypodophyllotoxin (25-75 nM; 6-48 hours) increases the percentage of early apoptotic cell population from 2.05 to 5.62 and 18.49% for 24 h and 48 h, respectively. Deoxypodophyllotoxin (25-75 nM; 6-48 hours) treats SGC-7901 cells arrested in G2/M phase in time- and dose- dependent manners. Deoxypodophyllotoxin (25-75 nM; 6-48 hours) results in a remarkably time- and dose-dependent decrease in Cdc2 and Cdc25C expression levels and increases cyclin B1 within 6h, decreases PARP, Bcl-2 and caspase-3 activity. Apoptosis Analysis Cell Line: SGC-7901 cells Concentration: 25, 50, 75 nM Incubation Time: 6, 12, 24, 48 hours Result: Induced apoptosis in SGC-7901 Cells. Cell Cycle Analysis Cell Line: SGC-7901 cells Concentration: 25, 50, 75 nM Incubation Time: 6, 12, 24, 48 hours Result: Induced G2/M cell cycle arrest in SGC-7901 Cells Western Blot Analysis Cell Line: SGC-7901 cells Concentration: 25, 50, 75 nM Incubation Time: 6, 12, 24, 48 hours Result: Altered the expression of cyclin B1, Cdc2,Cdc25C, p-PARP, Bcl-2 and p-caspase-3 proteins. |
| In vivo study | Deoxypodophyllotoxin (intravenously injected; 5, 10, and 20 mg/kg; 3 times a week; 28 days) suppresses the tumors in a dose-dependent manner, the growth of tumors is inhibited by 22.19%, 47.91% and 50.93% with DPT at 5, 10 and 20 mg/kg, respectively. Animal Model: Xenograft model of gastric cancer in nude mice with SGC-7901 cells Dosage: 5, 10, and 20 mg/kg Administration: Intravenously injected; 5, 10, and 20 mg/kg; 3 times a week; 28 days Result: Inhibited the growth of gastric cancer tumors. |
Podophyllotoxin 9-Desoxy Impurity - Reference
| Reference Show more | Wang Linna, Hu Peiyang, Guangyi. Simultaneous determination of six kinds of podophyllolignans by UPLC-MS/MS and its pharmacokinetics [J]. Journal of Hubei University of Medicine, 2017(05):411-417. |
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