Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride
Polihexanide HCl
CAS: 32289-58-0
Molecular Formula: (C8H17N5)n.xHCl
Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride - Names and Identifiers
| Name | Polihexanide HCl |
| Synonyms | PHMB hexan-1-ide Polihexanide HCl Polyhexamethylene Biguanide HCl Poly(hexamethylenebiguanide)hydrochloride Polyhexamethylene biguanide Hydrochloride Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride |
| CAS | 32289-58-0 |
| EINECS | 1308068-626-2 |
| InChI | InChI=1/C18H40N10.ClH/c1-15(19)24-11-7-3-4-9-13-26-17(21)28-18(22)27-14-10-6-5-8-12-25-16(20)23-2;/h3-14H2,1-2H3,(H2,19,24)(H3,20,23,25)(H5,21,22,26,27,28);1H |
Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride - Physico-chemical Properties
| Molecular Formula | (C8H17N5)n.xHCl |
| Molar Mass | 433.038 |
| Solubility | Water |
| Storage Condition | Inert atmosphere,Room Temperature |
| Physical and Chemical Properties | Polyhexamethylene biguanide hydrochloride solution is a colorless or light yellow transparent liquid. The guanidine group has high activity, which can make the polymer positive, and it is easy to be negatively charged. Various bacteria and viruses are adsorbed, thereby inhibiting the ability of bacteria and viruses to divide, causing them to lose their reproductive ability, and the film formed by the polymer blocks the respiratory channels of microorganisms, causing microorganisms to die quickly. |
| Use | The average molecular weight of polyhexamethylene biguanide hydrochloride is 1100~1800, and the molecular formula is (C8H17N5)n xHCl,n = 12-16. Polyhexamethylene biguanide hydrochloride (PHMB) is a broad-spectrum antibiotic, which has a killing effect on gram-positive bacteria, gram-negative bacteria, fungi and yeasts. |
Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride - safety
Open Data Verified Data
This product has LD50>2500mg/kg. The original solution of the product has a slight irritation to the eyes due to its high concentration. No irritation or corrosion at the recommended concentration. Store in a cool, dry, shaded, and sealed environment.
Last Update：2023-10-12 11:38:05
Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride - Preparation method
Open Data Verified Data
Polyhexamethylene biguanidine hydrochloride is generally prepared by reacting hexamethylene diamine with a salt of dicyandiamide to produce a dicyandiamide salt of hexamethylene diamine, which is then treated with hexamethylene diamine and 36% hydrochloric acid.
1. Preparation of Hexanediamine Hydrochloride
Add ethanol and 1,6-hexanediamine to the reactor, and add hydrochloric acid dropwise with stirring. During the dropwise addition process, maintain the temperature below 28 ℃ until the solution pH value is 5. After dripping, continue the reaction for 1 hour, then cool to 0 ℃, filter, and dry to obtain hexanediamine hydrochloride.
2. Preparation of polyhexamethylene biguanidine hydrochloride
Add dicyandiamide and hexanediamine hydrochloride with a molar ratio of 1:1.1 to the reaction kettle, add a certain amount of n-butanol as the solvent, stir and reflux at 170 ℃ for 12 hours, and steam out n-butanol to obtain the product.
Last Update：2024-01-02 23:10:35
Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride - Antibacterial mechanism
Polyhexamethylene biguanide hydrochloride PHMB is a cell membrane active antibacterial agent. Its inhibitory effect on bacterial activity is higher than that of fungi. Its antibacterial mechanism is roughly as follows: First, PHMB is a polycationic compound, It will be adsorbed on the surface of negatively charged microorganisms to prevent their division and reproduction; at the same time, the PHMB adsorbed on the surface of microorganisms acts on the phospholipid bilayer in the cytoplasm through transmembrane transportation, and combines with the negatively charged phosphoric acid group, this changes the selective permeability of cell membranes, disrupts cell metabolism, and kills microorganisms.
Last Update：2024-04-10 22:40:09
Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride - Use
disinfectant. This fungicide is broad-spectrum antibacterial and has the ability to kill Gram-positive bacteria, Gram-negative bacteria, fungi and yeasts; it can be used as a fungicide and is often used in swimming pool fungicides, universal cleaners and disinfectants Products.
Last Update：2024-04-10 22:29:15
Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride - Application
For a long time, polyhexamethylene biguanide hydrochloride PHMB has been widely used in medicine for sterilization and antiseptic. As a pharmaceutical product, it is used for disinfection of contact lenses, eye drops, and surgery. Due to the strong tolerance of eyes to PHMB, it can be used as a medicine for the treatment of Acanthamoeba keratitis, prevention and treatment of other eye diseases. At the same time, PHMB is also widely used in cosmetics, personal care products, textiles, food industry, etc.
With the development of science and technology, polyhexamethylene biguanide hydrochloride has many new applications. For example, it is used as a flocculant, as a bactericidal algicide in swimming pools and industrial water treatment, as a bactericide in oil recovery and water injection, and can clean and remove harmful substances on glassware and other hard surfaces.
Last Update：2024-04-09 21:04:16
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