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PotassiuM tert-butyl alcohol

Potassium tert-butoxide

CAS: 865-47-4

Molecular Formula: C4H9KO

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PotassiuM tert-butyl alcohol - Names and Identifiers

Name Potassium tert-butoxide
Synonyms KTB
PTB
Potassiumtbutoxide
potassium-butoxide
Potassium t-butoxide
Potassium tert-butoxide
Potassium tert-butylate
potassium tert-butanolate
Potassium Tertiary Butoxide
PotassiuM tert-butyl alcohol
BuOk(PotassiuM tert-butoxide)
2-methyl-2-propanopotassiumsalt
potassium 2-methylpropan-2-olate
2-Propanol,2-methyl-,potassiumsalt
N-(2-Chlorobenzyloxycarbonyloxy) succinimide
PotassiuM tert-butoxide solution 1.0 M in THF
PotassiuM tert-butoxide, 1.0 M solution in THF, SpcSeal
PotassiuM tert-butoxide, 1.8 M solution in THF, SpcSeal
PotassiuM tert-butoxide, 1.0 M solution in tert-Butanol , SpcSeal
CAS 865-47-4
EINECS 212-740-3
InChI InChI=1/C4H10O.K/c1-4(2,3)5;/h5H,1-3H3;/q;+1
InChIKey LPNYRYFBWFDTMA-UHFFFAOYSA-N

PotassiuM tert-butyl alcohol - Physico-chemical Properties

Molecular FormulaC4H9KO
Molar Mass112.21
Density0.910g/mLat 20°C
Melting Point256-258 °C (dec.) (lit.)
Boling Point275°C
Flash Point54°F
Water SolubilityREACTS
Solubility Soluble in hexane, toluene, diethyl ether and terahydrofuran.
Vapor Presure1 mm Hg ( 220 °C)
AppearanceWhite-like crystal
Specific Gravity0.902
ColorWhite to off-white
BRN3556712
pKapK1:18(25°C)
PH13 (5g/l, H2O, 20℃)Hydrolysis
Storage ConditionStore below +30°C.
StabilityStable, but reacts violently with water and acids, possibly leading to fire. Incompatible with water, acids, halogenated hydrocarbons, alcohols, strong oxidizing agents, ketones, carbon dioxide.
SensitiveMoisture Sensitive
MDLMFCD00012162
UseAs a strong base, it is widely used in chemical, pharmaceutical, pesticide and other organic synthesis of condensation, rearrangement and ring opening reaction

PotassiuM tert-butyl alcohol - Risk and Safety

Risk CodesR11 - Highly Flammable
R19 - May form explosive peroxides
R22 - Harmful if swallowed
R34 - Causes burns
R35 - Causes severe burns
R14 - Reacts violently with water
R20 - Harmful by inhalation
R36/37 - Irritating to eyes and respiratory system.
R37 - Irritating to the respiratory system
Safety DescriptionS16 - Keep away from sources of ignition.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S43 - In case of fire use ... (there follows the type of fire-fighting equipment to be used.)
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S7/9 -
S8 - Keep container dry.
S43A -
S33 - Take precautionary measures against static discharges.
S27 - Take off immediately all contaminated clothing.
S29 - Do not empty into drains.
UN IDsUN 3274 3/PG 2
WGK Germany1
FLUKA BRAND F CODES10-21
TSCAYes
HS Code29051900
Hazard NoteFlammable solid/Corrosive
Hazard Class8
Packing GroupI

PotassiuM tert-butyl alcohol - Upstream Downstream Industry

Raw Materialstert-Butanol

PotassiuM tert-butyl alcohol - Introduction

Reacts with water and dissolves in methanol and ethanol. Slightly soluble in diethyl ether and benzene. It can be used as tetrahydrofuran or tert-butanol solution.
Last Update：2022-10-16 17:29:25

PotassiuM tert-butyl alcohol - Reference Information

EPA chemical substance information information provided by: ofmpeb.epa.gov (external link)
organic strong Base potassium tert-butoxide is an important organic base, which is more basic than potassium hydroxide. Because of the induction effect of (CH3)3CO-three methyl groups, it is more basic and active than other alcohols, so it is a good catalyst. In addition, as a strong base, potassium tert-butoxide is widely used in organic synthesis such as chemical, pharmaceutical, pesticide and the like, for example, transesterification, condensation, rearrangement, polymerization, ring opening, production of heavy metal Orthoesters and the like. It can be used to catalyze Michael addition reaction, Pinacol rearrangement reaction and Ramberg-Backlund rearrangement reaction; Potassium tert-butoxide is used as condensation agent, can be used to catalyze Darzens condensation reaction, Stobbe condensation reaction; it is also the most effective base for the traditional alkoxide-haloform reaction for the formation of dihalogenated carbenes. Therefore, potassium tert-butoxide is more and more favored by chemical, pharmaceutical, pesticide and other industries. Potassium tert-butoxide is widely used, so the demand for high purity potassium tert-butoxide is large at home and abroad. However, the production cost is higher than that of other alkali metal alkoxides, and the production technology needs to be improved, so the in-depth study of potassium tert-butoxide is particularly important.
Related chemical reaction 1, N-formyl-o-toluidine is used as raw material, reaction with potassium tert-butoxide at 350 ~ 360℃, indole is produced, separated, and then reacted with chloroacetic acid to obtain β-indole acetic acid. 2,β-cyclic citral first with propenyl magnesium bromide Grignard reaction to produce alcohol, the resulting alcohol and then oxidized to ketone, and then by tert-butoxide potassium as a catalyst for isomerization reaction to become β-urethane ketone. 3, using citral and Allyl Grignard reagent as raw materials, the reaction was carried out to produce 6,10-dimethyl -4-hydroxy -1,5,9, oxidation under the action of Collins reagent to produce 6, 10-dimethyl-1, 5, 9-11-trien-4-one, followed by isomerization under the action of potassium tert-butoxide, biochemical pseudodihydrodamophenone, in the presence of tin tetrachloride or phosphoric acid, cyclization can produce damatone. 4, with 2,6, 6-trimethylcyclohex-2-alkenyl formaldehyde and Allyl Grignard reagent reaction, cyclohexenyl butenyl alcohol is produced, and then oxidized under the action of copper, zinc catalyst, the formation of cyclohexenyl butenone, potassium tert-butoxide in the alkali solution isomerization, can be prepared by damophenone. 5, up to (Darzen) reaction: aldehyde, ketone in the presence of alkaline reagent, and alpha-halogenated ester of aldol type condensation reaction, while the loss of hydrogen halide, the formation of Alpha, Β-epoxy esters. Commonly used alkaline reagents are: sodium ethoxide, sodium Amino, sodium metal, potassium tert-butoxide and so on. 6, Stobbe reaction: aldehyde, ketone and succinate in the presence of alkaline catalyst (such as sodium ethoxide, potassium tert-butoxide, sodium chloride, etc.), succinic acid or a monoester thereof that produces a hydrocarbyl-substituted methylene group.
strong alkaline condensing agent potassium tert-butoxide is a kind of strong alkaline condensing agent, which is more alkaline than sodium methoxide and sodium ethoxide, at room temperature, this product is white or off-white solid powder, chemical formula (CH3)3C-O-K, molecular weight 112.21, density 0.929, melting point 256-258 ℃, boiling point 275 ℃. Easy to absorb moisture. Soluble in tert-butyl alcohol, its solution is more stable, commonly used in halogenated hydrocarbon dehydrohalogenation reaction. Decomposition by exposure to air. Water decomposition of potassium oxide and tert-butyl alcohol. It can be obtained by reacting tert-butyl alcohol with potassium metal and then distilling off tert-butyl alcohol under reduced pressure. Widely used in organic synthesis of condensation, rearrangement and ring opening reaction, generally with tert-butyl alcohol solution. Potassium tert-butoxide is an organic alkaline corrosion product, strong moisture absorption, should be sealed and stored, pay attention to fire prevention, sun protection and storage in a cool, ventilated and dry place.
laboratory preparation of potassium tert-butoxide method potassium metal was added to freshly distilled tert-butanol under nitrogen atmosphere, reflux to potassium after complete melting heat preservation 1H, distilled off excess of tert-butanol, the remaining white solid in the oil bath 180~190 ℃ vacuum drying more than 10h, can be obtained potassium tert-butoxide crystal powder, need to save under nitrogen, can not meet the air & water, or it will become pink, the yield of potassium to calculate if more than 99%, tert-butyl alcohol and potassium metal reaction to prepare potassium tert-butoxide chemical reaction equation is as follows:
note There are two types of potassium tert-butoxide: liquid and solid. Usually, the liquid industrial product is tert-butyl alcohol solution of potassium tert-butoxide, the color of the product is light yellow or milky white, slightly turbid, in which the content of potassium tert-butoxide is 10% ~ 12%; The solid product is generally white or white powder, the content of potassium tert-butoxide is 95% ~ 97%.
potassium tert-butoxide is an organic alkaline corrosion product, strong moisture absorption, should be sealed and stored in a cool, dry, ventilated warehouse, should be placed away from the heat source, Isolation fire, protection against sun exposure. Potassium tert-butoxide has a strong corrosive effect on the skin. During handling, operators should wear protective masks to prevent corrosion and burns caused by potassium tert-butoxide.
Use for pesticides, pharmaceuticals, printing and dyeing, catalysts, etc.
potassium tert-butoxide is widely used in chemical industry, medicine, pesticides and other organic synthesis in the condensation, rearrangement and ring opening reaction.
production method method -1250 of dry tert-butanol was distilled directly into the reaction flask under nitrogen. 100g (2.6g atoms) of potassium were added in 10 portions. The stirred mixture was immediately Fever and reached the melting point 62C of potassium in 15-60 minutes, at which time the metals were dispersed into dissolved droplets. As potassium gradually dissolves, the temperature of the mixture cuts to the boiling point of tert-butanol. The stirring speed was adjusted to keep the tert-butanol slightly under reflux. If the boiling was too intense, the stirring was stopped. If necessary, the reaction vessel can be cooled by immersion in a cold oil bath (water bath cannot be used). Potassium tert-butoxide gradually precipitated out, and when all the potassium had reacted, the mixture became a thick suspension. The second method is packed in a 3 liter three neck bottle with a sealed stirrer, a nitrogen inlet pipe (nitrogen is passed through a concentrated sulfuric acid washing bottle and an anhydrous calcium chloride drying tower), a 500 constant pressure dropping funnel and a reflux condenser, 500 of freshly distilled T-butanol was added and 20g (0.5 gram atoms) of cleaned potassium metal was added. When the potassium reaction was completed, the reflux condenser was changed to a 30cm long fractionation column. An amount of tert-butyl was distilled until crystals appeared in the solution. 2 L of dry heptane was added and the distillation was continued until the column top temperature reached 98 °c. The residue was added to dry heptane to 1.5 L. The resulting slurry was a 1:1 complex of potassium tert-butanol and tert-butanol. The solvent was removed at a reduced pressure of 20-25mm on a steam bath. It can be stored in a nitrogen atmosphere for several months.
autoignition temperature 483°C
Last Update：2024-04-10 22:29:15
PotassiuM tert-butyl alcohol
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CAS: 865-47-4
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
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Product Name: Potassium tert-butoxide Request for quotation
CAS: 865-47-4
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589 Click to send a QQ message
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Product Name: Potassium tert-butoxide Request for quotation
CAS: 865-47-4
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
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Tel: 18301782025
Email: 3008007409@qq.com
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Tel: 15169266669
Email: 199988801@qq.com
Mobile: 15169266669
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CAS: 865-47-4
Tel: 18905335819
Email: 852211386@qq.com
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View History
PotassiuM tert-butyl alcohol
Raw Materials for PotassiuM tert-butyl alcohol
tert-Butanol
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