Potassium hexamethyldisilazide

Name	1,1,1,3,3,3-Hexamethyldisilazane potassium salt
Synonyms	KHMDS Potassiumhexamethyldisilazane POTASSIUM HEXAMETHYLDISLAZANE POTASSIUMHEXAMETHYLDISILAZANE Potassium hexamethyldisilazide POTASSIUM HEXAMETHYLDISILAZIDE HEXAMETHYLDISLAZANE POTASSIUM SALT POTASSIUM BIS(TRIMETHYLSILYL)AMIDE Potassium bis(trimethylsilyl)amide HEXAMETHYLDISILAZANE POTASSIUM SALT Potassium bis(trimethylsilyl)amide in toluene 1,1,1,3,3,3-HEXAMETHYLDISILAZANE POTASSIUM SALT 1,1,1,3,3,3-Hexamethyldisilazane potassium salt potassium 1,1,1,3,3,3-hexamethyldisilazan-2-ide
CAS	40949-94-8
EINECS	424-100-2
InChI	InChI=1/C6H18NSi2.K/c1-8(2,3)7-9(4,5)6;/h1-6H3;/q-1;+1

Molecular Formula	C6H18KNSi2
Molar Mass	199.48
Density	0.877g/mLat 25°C
Melting Point	194-195°C
Boling Point	111 °C
Flash Point	45°F
Water Solubility	Reacts with water.
Solubility	Miscible with terahydrofuran, ether, benzene and toluene.
Vapor Presure	54 mm Hg ( 25 °C)
Vapor Density	3.2 (vs air)
Appearance	Liquid
Specific Gravity	0.877
Color	clear to slightly hazy yellow
BRN	4006754
Storage Condition	Refrigerator
Sensitive	8: reacts rapidly with moisture, water, protic solvents
Refractive Index	1.4920

Risk Codes	R14 - Reacts violently with water R34 - Causes burns R67 - Vapors may cause drowsiness and dizziness R65 - Harmful: May cause lung damage if swallowed R63 - Possible risk of harm to the unborn child R48/20 - R11 - Highly Flammable R40 - Limited evidence of a carcinogenic effect R36/37/38 - Irritating to eyes, respiratory system and skin. R19 - May form explosive peroxides R37 - Irritating to the respiratory system
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S62 - If swallowed, do not induce vomitting; seek medical advice immediately and show this container or label. S43 - In case of fire use ... (there follows the type of fire-fighting equipment to be used.) S46 - If swallowed, seek medical advice immediately and show this container or label. S16 - Keep away from sources of ignition. S36/37 - Wear suitable protective clothing and gloves.
UN IDs	UN 3263 8/PG 3
WGK Germany	3
FLUKA BRAND F CODES	1-3-10
TSCA	No
HS Code	29319090
Hazard Class	3
Packing Group	II

EPA chemical information	Information provided by: ofmpub.epa.gov (external link)
Introduction	Bis (trimethylsilyl) potassium amino, usually abbreviated as KHMDS, is a strong non-nucleophilic base, pKa is about 26 (Compared with lithium diisopropylamide, it is at 36). In the solid state, the unsolvated compound is a dimer, in which two potassium and two nitrogen atoms form a square. The compound is soluble in hydrocarbon solvents and has poor electrical conductivity in solution and melt. This is attributed to very strong ion pairing.
preparation	add 150g of anhydrous toluene and 19.5g(0.5mol) of metallic potassium to a 1000ml three-neck bottle, protect by argon gas, raise the temperature to 55 ℃, and add styrene/hexamethyldisilazane (65g/161g) dropwise; 0.625mol/1mol) mixture, and add dropwise in about 30 minutes. Keep the temperature for 2 hours until the metal potassium is completely dissolved, and the temperature is cooled to room temperature to obtain bis (trimethylsilyl) potassium amino (KHMDS) reaction solution.
Uses	Pharmaceutical intermediates, mainly used for the production of synthetic cephalosporin antibiotics Non-nucleophilic strong bases.

Last Update：2024-04-10 22:29:15

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