Name | Prasugrel Hcl |
Synonyms | Prasugrel Hcl Prasugrel HCl Unii-G89jq59I13 Prasugrenhydrochloride Prasugrel hydrochloride PRASUGREL HYDROCHLORIDE 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-2H,4H,5H,6H,7H,7aH-thieno[3,2-c]pyridin-2-one acetic acid [5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-6,7-dihydro-4H-thieno[3,2-c]pyridin-2-yl] ester 2-[2-(Acetyloxy)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]-1-cyclopropyl-2-(2-fluorophenyl)ethanone hydrochloride |
CAS | 389574-19-0 |
EINECS | 627-126-4 |
InChI | InChI=1/C20H20FNO3S.ClH/c1-12(23)25-18-10-14-11-22(9-8-17(14)26-18)19(20(24)13-6-7-13)15-4-2-3-5-16(15)21;/h2-5,10,13,19H,6-9,11H2,1H3;1H |
Molecular Formula | C20H20FNO3S.ClH |
Molar Mass | 409.907 |
Melting Point | >173?C (dec.) |
Boling Point | 493.5°C at 760 mmHg |
Flash Point | 252.3°C |
Solubility | Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly) |
Vapor Presure | 7.01E-10mmHg at 25°C |
Appearance | Solid |
Color | White to Pale Brown |
Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
Physical and Chemical Properties | White crystalline solid, soluble in methanol, ethanol, DMSO and other organic solvents, derived from biological fermentation. |
In vivo study | A single dose of 0.3-3 mg/kg prasugrel or multiple doses of 0.3 and 1 mg/kg/day prasugrel significantly inhibited arteriovenous shunting and electrically induced arterial thrombosis. This dose is similar to the dose that inhibits platelet activation through the P2Y12 receptor, suggesting that the protective effect of prasugrel in models of cerebral infarction and peripheral arterial occlusive disease reflects the inhibitory effect of P2Y12 on platelets through the active metabolite of prasugrel. Prasugrel can significantly prevent the progression of peripheral vascular lesions. |
HS Code | 2934990002 |